4656 papers
This study challenges the strict bifurcation model by demonstrating that while early memory T cells primarily arise from Granzyme A-negative precursors, Granzyme A-expressing terminal effector T cells can subsequently dedifferentiate into long-lived functional memory cells, resulting in a mixed memory population derived from both linear and bifurcated differentiation paths.
This study reports a ribozyme-optimized CVS-N2cΔG rabies virus platform that utilizes Twister-based configurations to dramatically enhance barcode diversity and rescue efficiency, thereby enabling high-fidelity, collision-free mapping of single-neuron projection connectivity in the mouse visual pathway.
This study reveals that sepsis is characterized by a reproducible immunometabolic state where activated glycolysis and lactate programs coincide with reduced expression of canonical lactylation regulators, a signature that correlates with monocyte dysfunction, clinical stratification, and early mortality risk.
This study utilizes synchronized sensor data to demonstrate that core muscle activation in figure skating jumps shifts from right-side to left-side dominance during flight and requires significantly higher oblique tension for triple jumps compared to doubles, driven by rotational velocity rather than airtime, thereby offering a quantitative framework for optimizing jump technique and strength training.
This paper demonstrates that Recursive Indexing (RIX) achieves early detection of stable pathway organization in NIST Bell-test event streams by revealing that path entropy stabilizes rapidly and that specific settings exhibit distinct compression patterns, enabling a conservative gate to classify run-prefix samples with 100% accuracy.
This paper presents a computational model demonstrating that altered gravity increases neuronal firing and burst rates by incorporating gravity-sensitive mechano-gated ion channels and firing rate adaptation into excitatory networks, thereby bridging the gap between historical observations and neuronal activity mechanisms.
This study demonstrates that self-supervised foundation models trained on unlabeled sleep EEG data capture fine-grained within-stage microstructure that provides incremental health screening value beyond traditional coarse staging and standard signal summaries.
This study demonstrates that hinokinin can be efficiently encapsulated into PLGA and PLGA-PEG nanoparticles with high stability and rapid release, though the resulting nanosystems showed comparable or reduced antiproliferative activity against cancer cells in vitro compared to the free drug.
This paper presents a low-dose, lensless deep-ultraviolet holographic microscopy platform utilizing standard visible-light CMOS sensors to achieve centimeter-scale, label-free biochemical imaging with high-throughput, chemically specific contrast and sub-micron resolution.
PREDetector v4.0 is an updated, interactive web platform that enables comprehensive genome-wide prediction and functional analysis of bacterial regulons by integrating over 9,000 genomes and 2,000 curated motifs with dynamic threshold adjustment, reliability assessment, and direct links to external annotation resources.