🧬 Category

q-bio

4656 papers

🧬 biology

FAK- and TGF-β1-dependent biomechanical alterations in microvascular endothelial cells exposed to spatial fluid shear stress gradients

This study reveals that spatial fluid shear stress gradients induce immediate and sustained biomechanical alterations in microvascular endothelial cells, including reduced migration speed, enhanced collective directional movement against the flow, and increased traction forces, which are mechanistically governed by FAK-mediated mechanotransduction and TGF-β1 signaling, respectively.

Julio César Sánchez-Rendón, Erva Keskin, Nadine Oder, Annalena Reuss, Eleftheria Michalaki, Gerald G. Fuller, Alexander (…)2026-06-26
🧬 biology

Opportunities, challenges and responsible innovation using generative artificial intelligence for biological sequence design

This white paper presents consensus recommendations from a multidisciplinary workshop proposing a three-tiered "defence-in-depth" governance framework to balance the transformative potential of generative AI in biological sequence design with the urgent need to mitigate risks related to data bias, model opacity, and dual-use threats.

Maximilian Sprang, Hassan Hassan, Yasha Ektefaie, Anne Schmieder, Alix Wasilenko, Moritz Hanke, Rosa Martín-Peña, Rachae (…)2026-06-26
🧬 biology

Discovery of plastid gene mutations causing albinism in chimeric Cornus cultivars (Cornaceae)

This study identifies specific deleterious plastid gene mutations responsible for albinism in chimeric *Cornus* cultivars, resolves their maternal phylogenetic lineages, and develops molecular markers to distinguish these morphologically similar varieties for precision breeding.

Hayan Lee, Jickerson Lado, Hyeji Lee, Yeon Jeong Kim, Yun Sun Lee, Jong-Soo Kang, Jee Young Park, Jung Hwa Kang, Hak Che (…)2026-06-26
🧬 biology

Valorization of Freshwater Crab Derived Astaxanthin from Spiralothelphusa hydrodroma (Herbst, 1794) with Enhanced Antioxidant and Antibacterial Efficiency

This study demonstrates that the shells of the freshwater crab *Spiralothelphusa hydrodroma* serve as a superior natural source of astaxanthin compared to its tissues, exhibiting high extraction yields and significant antioxidant and antibacterial activities that support their potential use in nutraceutical and pharmaceutical applications.

Shanthi Rangasamy, Sowmiya Sundararajan, Monica Prakash, Sivakumar Mullaivanam Ramasamy2026-06-26
🧬 biology

ResVGGFormer: A Hybrid Residual-enhanced VGG-Transformer model for Predicting Multi-type RNA Modification Site in S. cerevisiae

This paper introduces ResVGGFormer, a hybrid deep learning framework that combines a residual-enhanced VGG-style backbone with a Transformer encoder to efficiently and accurately predict multi-type RNA modification sites in *S. cerevisiae*, achieving state-of-the-art performance and superior training efficiency compared to existing baselines.

Wei Liu, Kaiyang Li, Xiangzhi Wang, Le Ding, Shuo Xu, Yan Yang, Rui Zhang, Tongnan Yin2026-06-26
🧬 biology

The Invisible Engine of Cymbidium goeringii Nutritional Growth - Mycorrhizal Symbiosis

This study identifies a specific *Ceratobasidiaceae* fungus (KMGT47) isolated from the photosynthetic orchid *Cymbidium goeringii* as being identical to an ectomycorrhizal fungus of *Pinus yunnanensis*, thereby providing the first evidence of a tripartite symbiosis where carbon is transferred from the pine to the orchid via shared fungal hyphae.

Jianxin Chen, Xiang Ma, Fengjinglin Wu, Youjiao Zhu, Fang Wang, Xingliang Xu, Jianrong Wu2026-06-26
🧬 biology

Prefrontal pyramidal neuron dysregulation impairs prefrontal-thalamic circuit function and underlies working memory retrieval deficits in Alzheimer’s disease

This study demonstrates that dysregulation of prefrontal pyramidal neurons disrupts mPFC-thalamic circuit function and impairs working memory in Alzheimer's disease, but that optogenetic restoration of these neurons' excitability can rescue circuit dynamics and cognitive deficits.

shengnan Zhang, Liusi Gong, Tiaotiao Liu, Aili Liu, Xin Tian, Xuyuan Zheng, Wenwen Bai2026-06-26
🧬 biology

Endocrine-Microbial Trade-offs under Extreme Cold and Physical Stress: Multi-omics Network Reveals Tryptophan/Lipid Reprogramming and the Cost of Cortisol Overload

This multi-omics study reveals that under extreme cold and physical stress, high-endurance individuals maintain metabolic stability through a "metabolic trade-off" strategy that prioritizes lipid mobilization and Christensenellaceae enrichment at the cost of local intestinal immunity, whereas maladapted individuals suffer from cortisol overload, Fusobacterium proliferation, and systemic inflammation.

Haonan Sun, Lixia Yu, Jiafan Liang, Jiahui Chen, Guoping Zhao, Zhanxin Yao, Yanbo Wang2026-06-26
🧬 biology

A Hybrid Grey Wolf Optimizer and Differential Evolution Wrapper for Descriptor Selection in QSAR Modelling

This paper proposes a hybrid Grey Wolf Optimizer and Differential Evolution wrapper for descriptor selection in QSAR modelling, demonstrating that while the method significantly improves predictive accuracy and reduces dimensionality on high-redundancy solubility datasets, its benefits are dataset-dependent and do not universally outperform regularized full-descriptor models.

Suprava Ghosh, Mrinal Kanti Rajak2026-06-26