q-bio papers | Gist.Science

Cross-individual generalizability of machine learning models for ball speed prediction in baseball pitching

This study evaluates the cross-individual generalizability of machine learning models for predicting baseball pitch speed across 50 pitchers, revealing that while within-individual performance is high, generalization drops significantly and varies by expertise level and specific body segments, highlighting the need for cross-individual validation to improve practical applicability in sports science.

Ryota Takamido, Chiharu Suzuki, Hiroki Nakamoto2026-06-26

🧬 biology

Fear of the new: a predatory invader provokes stronger non-consumptive effects on a keystone native prey than a native predator

This study demonstrates that the invasive brown bullhead catfish induces stronger non-consumptive effects on the native keystone freshwater crayfish *Paranephrops planifrons* than the native longfin eel, likely due to the crayfish's heightened fear response to unfamiliar predator cues, posing a significant ecological threat as the invader's range expands.

Olivier Valentijn Raven, Calum MacNeil, Finnbar Lee, Robin Holmes, Ian A. K. Kusabs, Francis J. Burdon, Deniz Özkundakci2026-06-26

🧬 biology

Differences in root architecture influence the persistence time of competing species in simulated plant communities

Using a functional-structural plant model, this study demonstrates that greater divergence in root architecture extends the persistence time of competing plant species through density-dependent recovery mechanisms, whereas ecologically identical species rely on neutral drift for their persistence.

Hugo Salinas, Erik J. Veneklaas, Elizabeth Trevenen, Michael Renton2026-06-26

🧬 biology

Joint Generative Modeling of EEG and fMRI for Cognitive Task Simulation Using Adversarial Learning

This paper proposes a novel joint EEG-fMRI generative adversarial network (GAN) framework that successfully synthesizes statistically plausible, cross-modal brain activity patterns for cognitive tasks, demonstrating high accuracy in data augmentation and privacy preservation for neuroscience research.

Nirmal S Nair, Ravi Prakash B2026-06-26

🧬 biology

The CdGAP C-terminal pro-invasive domain drives breast cancer metastasis and activates WNT signaling

This study reveals that the C-terminal pro-invasive domain of CdGAP drives breast cancer metastasis by interacting with LIMD1 to activate WNT signaling, identifying this GAP-independent mechanism as a critical therapeutic target for triple-negative breast cancer.

Nathalie Lamarche-Vane, Monica Lara-Marquez, Nadia Boufaied, YI HE, Jennifer Chapelle, Jalal Al Rahbani, Ellie Massey, N (…)2026-06-26

🧬 biology

A rotated multivariate linear mixed model for dual large-scale genome-wide association study

The paper introduces RmvLMM, a scalable and powerful statistical framework that utilizes orthogonal rotation and a parallelized divided-and-combined strategy to overcome computational bottlenecks in large-scale multi-trait genome-wide association studies, demonstrating superior efficiency and power over existing tools like GEMMA while successfully identifying significant genetic variants and drug targets in UK Biobank data.

Qizhai Li, Hongping Guo, Qinyuan Zhang, Xueqin Zheng, Yuan Quan2026-06-26

🧬 biology

Chromosome-level genome assembly of landrace ‘Huangzhou’ provides insights into high cellulose accumulation in radish

This study presents a high-quality, haplotype-resolved genome assembly of the landrace radish 'Huangzhou', revealing that its high dry matter content is driven by increased cellulose accumulation and upregulated cellulose synthase genes, while also identifying genetic adaptations to local environmental conditions.

Shi-Sheng Li, KE XU, Yujia Liu, Huan Liu, Yuanyuan Tan, Wei Tu, Hongjin Dong, Haiping Xin, Changjun Ge, Lei Gao, Xiaofen (…)2026-06-26

🧬 biology

CRISPR-Cas9 and CRISPR-dCas9-Mediated Targeting of mecA, agrA, and spa in Multidrug-Resistant Staphylococcus aureus

This study demonstrates that programmable CRISPR-Cas9 and CRISPR-dCas9 systems can be engineered to specifically target resistance and virulence genes in multidrug-resistant Staphylococcus aureus, achieving either bactericidal elimination of mecA or selective suppression of virulence factors like agrA and spa without compromising bacterial viability.

Preethi Chandran, Shubha Gopal2026-06-26

🧬 biology

β-Hydroxybutyrate maintains energetically demanding neural functions during glucose deprivation

This study demonstrates that β-hydroxybutyrate can independently sustain essential metabolic and functional properties of brain tissue, including the ability to recover from severe energetic challenges, in the complete absence of exogenous glucose.

Rachel L. Ricks, Dallin S. Nevers, Tyler Poulos, T. Luke Shafer, Clayton Dunford, Paul R. Reynolds, Benjamin T. Bikman (…)2026-06-26

🧬 biology

Combined exposure to copper and polypropylene microplastics alters metal partitioning, chlorophyll homeostasis and phenylpropanoid metabolism in Nymphaea ‘Black Beauty’

This study demonstrates that polypropylene microplastics alter copper partitioning in *Nymphaea* 'Black Beauty' by shifting copper accumulation from roots to leaves, thereby intensifying chlorophyll loss and triggering distinct organ-specific metabolic and transcriptomic stress responses.

Yuhong Rong, Hongjun Mu, Ziyu Li, Zhaohao Zhang, Jiang Xie, Yongbo Zhang, Yanyin Xu, Shen Xiong, Zesen Lai, Haiying Xion (…)2026-06-26

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