4656 papers
This study demonstrates that habitual physical activity selectively preserves core mitochondrial bioenergetic programs and energetic function in human skeletal muscle and other tissues by counteracting the specific, coordinated proteomic remodeling associated with aging.
This paper presents a computationally efficient reduced model of AMPA receptors that captures TARP-dependent kinetic differences, revealing how variable TARP expression enables neuronal firing during low-frequency stimulation and offering a valuable tool for investigating epilepsy-related network excitability.
This study systematically identifies ten ARR-B genes in watermelon, characterizing their genomic features, subcellular localization, and expression patterns to reveal their critical roles in plant development and specific responses to drought, salt, and cold stresses.
This study compares three eye-tracking-enabled VR headsets for behavioral research and finds that the Meta Quest Pro offers superior practical suitability due to its higher data yield, better usability, and lower cybersickness, despite the HP Reverb G2 Omnicept demonstrating lower angular error in successful sessions.
This study reports the first identification of a bisexual population of the previously considered parthenogenetic tick *Amblyomma rotundatum* in the Amazon biome of Brazil, demonstrating the presence of males and females in comparable proportions both in the field and under laboratory conditions.
This study identifies UCHL1 as an oncogenic deubiquitinase that drives lung cancer progression by stabilizing the YAP1 protein and reprogramming ceramide metabolism, thereby establishing the UCHL1–YAP1–ceramide axis as a promising therapeutic target.
This study reveals that global Gabrd deficiency triggers a developmentally restricted, compensatory mechanism involving Pleiotrophin-mediated myelination of parvalbumin-positive inhibitory axons, which fortifies seizure resistance and suggests myelination enhancement as a novel therapeutic strategy for refractory epilepsy.
This study utilizes molecular dynamics simulations to elucidate the structural determinants of the essential PEX5–PEX14 interaction in trypanosomes and identifies SuFEx-derived naphthoquinones as promising small-molecule inhibitors that effectively mimic the native recognition motif to disrupt glycosomal protein import.
This systematic qualitative synthesis reveals that physical activity, alongside other lifestyle factors like diet, BMI, and smoking, significantly modulates the gut microbiome by increasing beneficial commensal bacteria and anti-inflammatory modulators.
This paper introduces Nonlinear Fourier Re-weighting (NFR), a rapid, prior-free algorithm that enhances microscopy resolution by non-iteratively re-balancing Fourier spectrum components, effectively overcoming optical diffraction limits and aberrations without requiring a point spread function.