4656 papers
This study demonstrates that transcriptional heterogeneity, rather than mean gene expression, predicts clonal selection in ageing haematopoiesis by revealing that increased variability in stem cell gene expression programs drives the expansion of specific clones and is conserved across species as a marker for myeloid malignancy risk.
This study demonstrates that compensatory lung growth following pneumonectomy is a regionally specific process driven by Fgfr2b signaling, which is essential for maintaining epithelial integrity and preventing fibrotic remodeling, with an embryonic Fgfr2b-responsive signature that is diminished in human lung diseases.
This paper proposes that the Gini coefficient serves as a useful non-parametric metric to assess the regulability and origin of metabolites, demonstrating that tightly regulated endogenous compounds exhibit low coefficients while exogenous substances show higher values, with ergothioneine displaying intermediate variability indicative of its dietary origin.
This study introduces two geometric measures of EEG spectral dynamics, trajectory curvature and effective rank, which reliably distinguish conscious from unconscious states across both propofol anesthesia and natural sleep, offering a mechanism-sensitive tool for tracking the loss of consciousness.
This study demonstrates that intraspecific variation in pre-existing arbuscular mycorrhizal fungal colonization patterns and associated root traits, such as root diameter and tissue density, is critical for predicting drought and nutrient stress tolerance in alfalfa and sainfoin.
This study reveals that Chikungunya virus non-structural protein 3 (nsP3) hijacks the host Hsp70-TOM20 axis to trigger PINK1/Parkin-independent mitophagy, thereby degrading the mitochondrial antiviral signaling protein (MAVS) and enabling immune evasion.
This study demonstrates that smoke-derived compounds, specifically karrikin 1 and mandelonitrile cyanohydrin, can stimulate or inhibit the germination of Cerrado ground-layer species in a concentration- and species-dependent manner, offering potential applications for ecological restoration.
This study identifies widespread, depth-structured phages encoding the ammonia oxidation gene *amoC* that actively infect specific bacterial hosts in freshwater lakes, revealing a previously overlooked viral contribution to the nitrogen cycle.
This study presents a graphene-based electro-biosensing methodology that utilizes a wearable quantum transducer interface to achieve real-time, non-invasive monitoring of tissue stress and dynamic homeostatic regulation through bidirectional phase-inversion feedback.
This study demonstrates that ISGylation of STING drives neuroinflammation and dopaminergic neuronal death in Parkinson's disease models by activating c-Fos through a positive feedback loop, suggesting that targeting this ISG15-STING axis offers a novel therapeutic strategy.