🧬 Category

q-bio

1504 papers

🧬 biology

Sugar-Driven Information Loss in Minimal Synthetic Cells as a Model for Metabolic Aging

This paper proposes a minimal synthetic cell model that quantifies metabolic aging as sugar-driven information loss by linking chiral scaffold degradation via non-enzymatic glycation to a measurable decrease in configurational entropy, thereby establishing a falsifiable, experimentally accessible framework where the balance between repair and glycation rates governs the system's resistance to metabolic drift.

Leon Sandler2026-07-14
🧬 biology

A tunable receptor separates root barrier formation from nutrient signaling through ligand-perception states

This study demonstrates that the receptor kinase SCHENGEN3 uncouples root Casparian strip formation from systemic nutrient signaling by linking distinct receptor-ligand perception states to specific developmental and physiological outputs, revealing evolutionary divergence in pathway deployment between *Arabidopsis* and *Lotus*.

Tonni Andersen, Yuanyuan Zhang, Sebastian Samwald, Anika Schröder, Sara Stolze, Swati Mahiwal, Tianquan Lu, Jakub Rzemie (…)2026-07-14
🧬 biology

Analysis Between Single Nucleotide Polymorphisms of Candidate Genes in the GABA System and Cognitive Performance

This study investigated 670 Taiwanese high school students and found that specific single nucleotide polymorphisms (SNPs) in GABA-related genes (GABRA4, GABRG2, GABBR1, and GABRQ) are significantly associated with variations in diverse cognitive abilities, suggesting a genetic basis for individual learning differences that could inform personalized education strategies.

Pan-Rui Lee, Ting-Kuang Yeh, Chun-Yen Chang2026-07-14
🧬 biology

LRRK2-G2019S couples metabolic stress to astrocytic senescence through DDB1-mediated p21 stabilization in Parkinson's disease

This study reveals that the Parkinson's disease-associated LRRK2-G2019S mutation exacerbates metabolic stress-induced neurodegeneration by stabilizing p21 via a kinase-independent interaction with DDB1 to drive astrocytic senescence, a pathological process that can be reversed by LED-based photobiomodulation.

Jee Hoon Lee, Ji-hye Han, Hang Chan Jo, Ilo Jou, Dae Yu Kim2026-07-14
🧬 biology

NRF2-Driven Lipophagy Promotes Lipid Droplet Turnover and Rewires Microglial Immunometabolism after Spinal Cord Injury

This study demonstrates that activating NRF2 to restore lipophagy, rather than inhibiting lipid droplet biogenesis, resolves lipid accumulation in microglia, thereby rewiring their immunometabolism to reduce neuroinflammation and promote neuronal survival following spinal cord injury.

LIYANG SHI, Chaoyong He, Yuyun Liang, Runxiang Yao, Hexu Zhang, Ke Jian, Yueren Wu, Houzhi Kang, Jiayi Pi, Can Zhang, Qi (…)2026-07-14
🧬 biology

quantmsdiann: a scalable SDRF-driven DIA-NN workflow for reanalysis of single-cell, spatial, and bulk proteomics datasets

The paper introduces quantmsdiann, a scalable, open-source Nextflow workflow that standardizes and accelerates the reanalysis of diverse DIA proteomics datasets using the latest DIA-NN versions, significantly improving protein identification rates and enabling large-scale meta-analyses through reproducible, cloud-ready processing.

Qi-Xuan Yue, Yufei Shen, Chengxin Dai, Asier Larrea-Sebal, Henry Webel, Jose Nimo, Fabian Coscia, Orhun Kok, Nikolai Sla (…)2026-07-14
🧬 biology

Transcriptomic Profiling of Colorectal Cancer Cell Lines Reveals Novel Divergent Splicing Modalities in Long Non-Coding RNAs GAS5 and SNHG1

This study utilizes a reproducible transcriptomic pipeline to reveal that colorectal cancer cell lines exhibit tissue-specific, divergent splicing modalities in the lncRNAs GAS5 and SNHG1—distinct from patterns observed in esophageal cancer—that are likely underreported in public databases due to tumor dilution and Poly-A selection biases.

John Mathew Manipadam2026-07-14