3747 papers
This study demonstrates that Shank3-deficient rats on a Long-Evans background exhibit preserved basic sensorimotor and social behaviors but display significant impairments in executive function, highlighting high-order cognitive dysfunction as a primary consequence of Shank3 loss.
This study introduces PGC-pro, a multimodal deep learning model that integrates H&E histopathology images, gene expression profiles, and clinical data to significantly improve gastric cancer prognostic accuracy and interpretability compared to single-modal approaches.
This study utilizes computational fluid dynamics to demonstrate that the spatial arrangement of fibers in porous media, rather than volume fraction alone, is the primary determinant of residence time distribution variability, with ordered hexagonal structures promoting plug-flow behavior while clustered configurations induce significant dispersion and prolonged mean residence times.
This study demonstrates that the ethylene response factor OfERF16 delays postharvest petal senescence in *Osmanthus fragrans* by enhancing redox homeostasis and interacting with OfMYB306, while also altering floral architecture and being transcriptionally repressed by OfbHLH68.
Overexpression of the *icd* gene in *Synechocystis* sp. PCC 6803 enhances nitrogen assimilation by increasing 2-oxoglutarate supply, which expands electron sink capacity and consequently boosts photosynthetic activity and glycogen accumulation.
This study demonstrates that the hepatic microcirculatory bed and parenchyma of piglets undergo a hierarchical transformation over the first 20 days after birth, evolving from an immature, non-oriented prenatal state into a mature, radially organized lobular structure through the coexistence of transitional architectures and the elimination of provisional features.
This study introduces a novel dual targeted/untargeted LC–MS/MS protocol to reveal that macroevolutionary conservation and ontogenetic optimization of aristolochic acid defenses in *Aristolochia* plants are driven by coevolutionary pressures from their specialist herbivore, the *Battus philenor* butterfly.
This global meta-analysis of 269 trials reveals that arbuscular mycorrhizal fungal inoculation generally promotes the expansion of root systems in non-woody plants by increasing surface area, length, and biomass, with these morphological responses being primarily driven by host plant family rather than fungal traits or environmental stress.
This study demonstrates that while behavioral data can constrain specific directions in the parameter space of whole-organism nervous system models, the vast majority of connectome-scale parameters remain undetermined, with the extent of identifiability depending on the diversity and functional demands of the elicited behaviors.
This study reveals that while body mass scales positively with basal metabolic rate in *Myotis velifer*, individual variation in metabolic rate is only weakly explained by body size, age, or reproductive status, suggesting that other intrinsic and ecological factors drive energy expenditure within maternity colonies.