3746 papers
This study demonstrates that CCDC180 is an evolutionarily conserved scaffold essential for C1 projection assembly in the ciliary central apparatus, as its deficiency in mice disrupts ciliary motility and sperm development, leading to postnatal hydrocephalus and complete male infertility.
This study reveals that M1 macrophages initiate labor by transferring mitochondria to myometrial myocytes via tunneling nanotubes, thereby boosting ATP production and triggering progesterone withdrawal through 20α-HSD upregulation.
This study demonstrates that although glymphatic clearance is primarily driven by inter-endfoot gaps, perivascular AQP4 critically regulates this process by modulating the pressure-volume balance and driving forces through dynamic hydraulic coupling, with its dysfunction significantly impairing net tracer transport.
This study demonstrates that combining polymyxin B nonapeptide (PMBN) with closantel restores potent bactericidal activity against mcr-1-carrying multidrug-resistant *E. coli* and *Salmonella* by permeabilizing the outer membrane to drive intracellular drug accumulation, leading to ATP depletion, metabolic collapse, and effective in vivo therapeutic outcomes.
This study presents the first targeted proteomic characterization of short-chain dehydrogenases/reductases (SDRs) in *Haemonchus contortus*, revealing sex-dependent expression patterns and identifying specific SDR isozymes that exhibit both constitutive overexpression in benzimidazole-resistant strains and inducibility by flubendazole, suggesting their potential role in anthelmintic adaptation.
This study demonstrates that community-level fine-root traits across 302 global plant communities exhibit multidimensional coordination consistent with the root economics space, where a collaboration axis is primarily driven by soil fertility and a fast–slow axis by climatic factors like precipitation and temperature.
This study demonstrates that sawdust supplementation significantly enhances the yield of *Trametes versicolor*, whose methanol extract exhibits potent antimicrobial activity against clinically isolated pathogens, with integrated in silico analyses identifying specific bioactive constituents as promising leads for targeting bacterial DNA gyrase B.
This study identifies and characterizes three novel fluorescent and chromoprotein variants from the sea anemone *Anthopleura dowii*, demonstrating their temperature-dependent solubility in *E. coli* and highlighting their potential as biotechnological tools while offering an explanation for the organism's color polymorphism.
This study characterizes the molecular polymorphism and evolution of CYP736 cytochrome P450 genes across wild *Vitis* species and *Muscadinia rotundifolia*, revealing that while these genes are under purifying selection with high sequence conservation, the resistance to Pierce's disease observed in specific hybrids is likely driven by regulatory mechanisms rather than coding-sequence divergence.
This study demonstrates that while maternal social support in mice effectively normalizes behavioral and hormonal deficits caused by prenatal stress, it does so not by restoring the offspring's brain transcriptome to a baseline state, but by activating a distinct, amplified adaptive transcriptional program that reshapes resilience.