1504 papers
This study analyzes high-resolution HLA variation across 390,823 diverse participants in the All of Us Research Program to demonstrate that while many HLA-disease associations appear ancestry-specific due to differences in allele frequency and statistical power, the underlying biological effects are largely shared across genetic ancestries.
This study demonstrates that cuticular hydrocarbons extracted from female *Cyclocephala barrerai* function as contact sex pheromones that elicit specific mating behaviors in males, with their chemical composition varying significantly as the insects' gonads mature.
This study demonstrates that while climate and geography are not robust predictors of immune receptor gene content across angiosperms once phylogenetic relationships are accounted for, woody and tree growth forms are consistently associated with elevated counts of specific cell-surface receptor genes, particularly LysM-RLKs.
This study demonstrates that oral melatonin alleviates Alzheimer's disease pathology and gut comorbidities in a mouse model by reshaping the gut microbiota to inhibit ferroptosis via the Keap1/Nrf2/HO-1 axis, thereby confirming a microbiota-dependent mechanism for its neuroprotective effects.
This study reports the isolation and characterization of two novel thermophilic bacterial strains, T41p and KhOGp, from high-altitude geothermal springs in Tajikistan, identifying them as distinct species within the genus *Thermobaculum* with significant biotechnological potential due to their robust growth conditions and diverse hydrolytic enzyme activities.
This study demonstrates that EEG-based closed-loop pacing effectively regulates neurophysiological task load dynamics during digital learning, supporting its potential as a state-regulation mechanism even when immediate accuracy gains are not observed.
This study of over 3,500 adolescents reveals that intrinsic infra-slow BOLD oscillations exhibit distinct spatial patterns, are linked to specific structural brain properties like cortical thickness and myelin, and are positively associated with performance across a wide range of cognitive functions.
This study integrates single-cell and transcriptome sequencing data to identify four macrophage polarization-related biomarkers (NRP2, ANXA1, TSPO, and FN1) that effectively diagnose intervertebral disc degeneration and elucidate their roles in immune cell interactions and potential therapeutic targeting.
This study demonstrates that distinct bacterial and fungal succession patterns occur in gravesoil beneath decomposing pig carcasses in central South Africa, supporting the potential of microbial metabarcoding as a supplementary method for estimating the postmortem interval in sub-Saharan forensic contexts.
This multi-omics study demonstrates that the protein kinase A subunit PKAc1 in *Trichoderma reesei* drives regulatory and phosphorylation remodeling essential for adapting to sugarcane bagasse, thereby modulating the expression and activity of key biomass-degrading enzymes.