1504 papers
This study employs an unbiased approach to identify disease-associated T-cell receptors in type 1 diabetes, linking them to convergent HLA-restricted clusters and revealing their specific targets as hybrid insulin peptides, thereby establishing these receptors as potential biomarkers and clarifying the role of effector T cells in disease pathogenesis.
This study demonstrates that synthesized hydroxyapatite nanoparticles (10–25 nm) are biocompatible and promote cutaneous tissue regeneration by enhancing cell migration and modulating the expression of key angiogenic and immunomodulatory genes (VEGF, FGF, IL-4, and IL-1β) in vitro.
Dietary supplementation of 1% Withania coagulans fruit powder enhances mucosal immunity and antioxidant defenses in zebrafish without affecting growth, whereas higher concentrations induce physiological stress and reduce these beneficial responses.
This study established an efficient Agrobacterium-mediated genetic transformation system for *Lycium barbarum* callus using optimized infection parameters and demonstrated that overexpression of the *LbMYB18* gene significantly enhances antioxidant capacity and photosynthetic pigment accumulation.
This study constructs a comprehensive single-cell atlas of endothelial cells across four endocrine organs, revealing distinct organ-specific transcriptional programs and immune-privileged vascular interfaces that are compromised during aging and tumorigenesis.
This study identifies Sorting Nexin 9 (SNX9) as a critical regulator that, upon relocating to mitochondria following fumarate hydratase inhibition, interacts with TMEM11 to facilitate the release of mitochondrial RNA into the cytosol, thereby triggering IFN-β production in LPS-activated macrophages.
This study demonstrates that *Anabasis articulata* seedlings exhibit exceptional salinity tolerance up to 300 mM NaCl through a combination of architectural restructuring, stable water homeostasis maintained by aquifer parenchyma, and the strategic use of sodium as an osmotic driver, highlighting its potential for restoring saline arid ecosystems.
This paper investigates the effectiveness of Low-Rank Adaptation (LoRA) for parameter-efficiently fine-tuning speech and bioacoustic self-supervised models on animal call-type identification, revealing that performance gains depend critically on adapter placement, layer selection, and dataset size, with broader projection adaptation outperforming direct feature extractor modification.
This study demonstrates that while acute mild-to-moderate hypoxia slows pilots' spatial cognitive processing speed without compromising accuracy, high levels of physical activity and a background in skill-based sports significantly buffer these negative effects, supporting recommendations for prioritizing active, skill-oriented athletes in high-altitude flight roles.
This study utilizes unsupervised machine learning on aberrant glycogene expression to identify six novel breast cancer subclasses that offer superior prognostic stratification compared to traditional markers, revealing distinct functional signatures with implications for immune interplay and personalized drug discovery.