🧬 Category

q-bio

3746 papers

🧬 biology

Integrated bioinformatic analysis identifies distinct neddylation-associated proteasome genes and immune-related features in laryngeal squamous cell carcinoma

This study integrates bioinformatic analysis and experimental validation to identify four specific neddylation-associated proteasome genes (KCTD6, PSMB2, PSMB4, and PSMD2) in laryngeal squamous cell carcinoma that exhibit distinct expression patterns and are significantly linked to metabolic pathways and immune microenvironment features.

Shujuan Wang, Jing Xu, Hong Ge2026-09-07
🧬 biology

Repeated Oral Manganese Exposure-Associated Hepatorenal Injury in BALB/c Mice: Integrated Evidence from Tissue Accumulation, Redox Imbalance, Inflammation, and Histopathology

This study demonstrates that repeated oral manganese exposure induces dose-dependent hepatorenal injury in BALB/c mice, characterized by tissue accumulation, redox imbalance, inflammation, enzyme alterations, and progressive histopathological damage.

Olumayowa Kolawole Idowu, Yusrah Folashade Sanusi, Tajudeen Olamide Ajadi, Tolulope Ayodeji Oni, Adewale Emmanuel Ajibad (…)2026-09-07
🧬 biology

Genetic and environmental factors driving functional trait variation in Pericopsis elata seedlings

This study reveals that functional trait variation in *Pericopsis elata* seedlings is primarily driven by environmental heterogeneity rather than genetic factors or local adaptation, suggesting that effective silviculture can be achieved through broad-scale family-level selection despite low heritability.

Jean Pierre Ngongo, Bloude L.B. Toumba-Paka, Janvier Lisingo, Surabhi Ranavat, Michael Dasse, Nils Bourland, Thomas Drou (…)2026-09-07
🧬 biology

Comparing virome composition between honey bees (Apis mellifera) and small carpenter bees (Ceratina calcarata) in response to various agricultural landscapes

This study utilizes RNA-Seq metatranscriptomics to compare the viromes of managed honey bees and wild small carpenter bees across agricultural landscapes, revealing species-specific viral prevalence, the discovery of novel insect viruses, and the influence of landscape on pollinator viral diversity.

Zixiao Zhao, Rameshwor Pudasaini, M. Catherine Farrell, Jayla Marvin, Sandra M. Rehan, Hongmei Li-Byarlay2026-09-07
🧬 biology

An energy-based model empowers ultra-large virtual screening against 100-billion-scale chemical libraries

The paper introduces DrugJEPA, an energy-based model that enables ultra-fast and cost-effective virtual screening of 100-billion-scale chemical libraries with state-of-the-art accuracy, successfully identifying potent nanomolar hits across diverse protein targets in wet-laboratory validation.

Shengyong Yang, Yuanyuan Jiang, Chong Huang, Mengzhe Dai, Rui Yao, Weining Sun, Liting Zhang, Qiao Huang2026-09-07
🧬 biology

From Transcriptomics to Game-Theoretic Models of Treatment Resistance in Glioblastoma Organoids

This study presents a data-driven systems biology framework that integrates transcriptomic analysis, machine learning, and game-theoretic modeling to predict evolutionary responses to irradiation in glioblastoma organoids, revealing hypoxia as a key driver of short-term resistance and demonstrating how such approaches can optimize personalized cancer therapies.

Louise Spekking, Christer Lohk, Weronika Jung, Maikel Verduin, Sepinoud Azimi, Christopher Hubert, Marc Vooijs, Rachel C (…)2026-09-07
🧬 biology

Seismic activity temporarily reshapes fin whale foraging radii

Using a deep learning-based acoustic localization model, this study demonstrates that submarine seismic events in the southwestern Indian Ocean cause significant, transient contractions in fin whale foraging radii, revealing a direct tectonic–biological linkage where acoustic disturbances force spatial restrictions that may lead to localized prey depletion.

Xuefeng Zhang, Xiaozhao Zhou, Jian Xu, Wen Zhang, Jun Wang, Ruixue Xia, Yuan Niu2026-09-07
🧬 biology

Characterization of N-Glycosylation Remodeling in Cerebrospinal Fluid Extracellular Vesicles in Children with Purulent Meningitis and Viral Meningitis: An Exploratory Glycomics Study Based on MALDI-TOF/TOF-MS

This exploratory study demonstrates that cerebrospinal fluid extracellular vesicles in children with purulent and viral meningitis exhibit distinct N-glycosylation remodeling patterns compared to disease controls, characterized by specific alterations in sialylation, galactosylation, and core fucosylation that correlate with inflammatory markers.

YUJIA RUAN, Yinfeng Shen2026-09-07