🧬 Category

q-bio

3746 papers

🧬 biology

Sterlet (Acipenser ruthenus) Surrogate maybe Reduce the Caviar Development of Critically Endandered Beluga (Huso huso)

This study demonstrates that intraperitoneal transplantation of Beluga spermatogonial cells into sterilized Sterlet larvae, particularly those treated with dnd-MO, successfully establishes germline chimeras with enhanced cell proliferation and retention, offering a promising surrogate strategy for the conservation and caviar production of critically endangered Beluga sturgeon.

Mahsa Borhani Peikani, Mohammad Reza Kalbassi, Martin Pšenička, Bahram Falahatkar, Alexander D. Crawford2026-09-07
🧬 biology

A sequential variant prioritization to identify genetic causes of hereditary angioedema in affected families from Spain and Portugal

This study utilized whole-exome sequencing and a sequential variant prioritization strategy in 102 Spanish and Portuguese families to identify 28 pathogenic variants, including novel mutations in *SERPING1* and *F12*, thereby expanding the mutational spectrum of hereditary angioedema and demonstrating that genetic testing of multiplex families significantly improves diagnostic yield.

Alejandro Mendoza-Alvarez, Luis A. Rubio-Rodríguez, Aitana Alonso-Gonzalez, Adrian Muñoz-Barrera, David Jáspez, Almudena (…)2026-09-07
🧬 biology

Brood signals dominate social regulation of reproduction and immunity in honey bees

This study demonstrates that in honey bees, the absence of brood acts as a more potent signal than queenlessness to trigger worker ovary activation and significantly enhance immunocompetence, revealing brood as a central regulator coordinating reproduction, pheromone signaling, and immune defense.

Alison McAfee, Leslie Holmes, Kelsey Gourlie, Jeff Kearns, Armando Alcazar Magaña, Renata Moravcova, Wendy Fang, Xiaojin (…)2026-09-07
🧬 biology

Early-life conditioning induces different transcriptional but not microbial responses to later life stress in diploid and triploid trout

This study demonstrates that early-life cold shock conditioning in diploid and triploid rainbow trout induces long-lasting, ploidy-dependent reductions in transcriptional stress responses to later-life crowding, whereas the gut microbiota responds to conditioning and stress independently without showing a conditioned memory effect.

Arun M Shankregowda, Benjamin Overland, Adriana L. Hotz, Matthew Hitchings, Catharine Aquino, Ralph Schlapbach, Carlos G (…)2026-09-07
🧬 biology

Interpretable machine Learning Links Wheat 55K SNP Variation to Breeding-trait Prediction and Candidate Locus Prioritization

This study develops an interpretable machine learning framework that successfully links 55K SNP variation to the prediction of key wheat breeding traits and prioritizes candidate loci, such as a significant signal on chromosome 4B overlapping the *Rht-B1* region, demonstrating the utility of such approaches even with moderate-sized, single-environment datasets.

Haifang Sun, Liang Hou, Hao Qi, Xiaorui Guo, Jianan Min, Shenglin Hou, Ying Wang, Xinshi Zhang, Zhehao Tian, Donghui Zha (…)2026-09-07
🧬 biology

Microcircuit Mechanisms of Primary Motor Cortex Dysfunction in Parkinsonism

Using a progressive mouse model of Parkinson's disease, this study identifies impaired α5-GABA A receptor-mediated inhibition and excessive NMDA receptor activation in primary motor cortex pyramidal neurons as key microcircuit mechanisms driving cortical dysfunction, which can be prevented or rescued by L-DOPA treatment at different disease stages.

Liqiang Chen, Hiba Douja Chehade, Samhitha Somavarapu, Hong-Yuan Chu2026-09-07
🧬 biology

PI3K/Akt Signaling Pathway Regulates Mitochondrial‑Dependent Apoptosis in Ovine Pulmonary Fibroblasts upon Mycoplasma ovipneumoniae Infection

This study demonstrates that *Mycoplasma ovipneumoniae* infection induces mitochondrial-dependent apoptosis in ovine pulmonary fibroblasts by accumulating reactive oxygen species (ROS) to inhibit the PI3K/Akt signaling pathway, thereby upregulating pro-apoptotic factors and downregulating anti-apoptotic proteins.

chen Li, Zhiyu Zhu, Qingyun Bu, Haoyu Sun, Yue Li, Yunfei Deng, kai wei2026-09-07
🧬 biology

Identification of Salivary Biomarkers from Gene Expression Data of Multiple Cancer Types Using Bioinformatics Analysis

This bioinformatics study identifies 80 common salivary mRNA biomarkers across five cancer types, highlighting IRAK3 and RBM6 as promising candidates for multi-cancer screening, prognosis, and immunotherapy selection based on their association with survival rates and immune cell infiltration.

Amirreza Safavinejad, Kiarash Zare, Yaser Mansoori, Elham Tayebi, Mohammad Mehdi Naghizadeh2026-09-07