1504 papers
This study demonstrates that specific, timely chemogenetic activation of the hypothalamic paraventricular nucleus inhibits cervical cancer progression by downregulating immune-related genes and curbing neutrophil infiltration through a newly identified brain-body axis.
This study demonstrates that myelin repair following focal demyelination is a spatially heterogeneous process shaped by distinct regional microenvironmental factors and cellular dynamics in the hippocampal fimbria and lateral olfactory tract, highlighting the need for region-tailored therapeutic strategies to enhance remyelination.
The paper introduces ionScell, an open-source Python pipeline that enables reliable, microscopy-independent single-cell spectral extraction from MALDI mass spectrometry imaging by deriving cell boundaries directly from Total Ion Current images, thereby achieving high-accuracy cell classification and revealing molecular heterogeneity without the need for co-registered microscopy or manual annotation.
This study reveals that under metabolic stress, the gut microbiota-derived metabolite indole-3-acetic acid (IAA), which is enriched by *Bacteroides fragilis* in PCOS patients, disrupts granulosa cell function and induces PCOS-like phenotypes by activating the aryl hydrocarbon receptor (AHR) signaling pathway.
This study establishes a novel eight-gene ferro-aging-related signature that serves as a robust prognostic indicator for cervical cancer, elucidates its association with an immunosuppressive tumor microenvironment and specific cell dynamics, and identifies potential therapeutic compounds through integrated multi-omics and AI-driven drug screening.
This study presents high-resolution structures of the antifungal target MCD4 from *Candida albicans* in complex with its natural inhibitor M743 and substrates, revealing a unique 16-transmembrane fold, a dimetal catalytic center, and a covalent inhibition mechanism that informs the development of new antifungal therapies.
Ilexgenin A induces cellular senescence in human non-small cell lung cancer NCI-H460 cells by inhibiting the PI3K/Akt signaling pathway, which promotes FOXO1 nuclear translocation and subsequent TXNIP upregulation.
This study reveals that forest degradation in the Amazon, even at relatively low disturbance levels, significantly alters vertebrate food web functioning by increasing carnivory and decreasing herbivory through shifts in species composition and biomass, demonstrating that energetic metrics are more sensitive indicators of ecosystem disruption than traditional biodiversity measures alone.
This study demonstrates that multi-generational exposure to glyphosate and glyphosate-based herbicides at doses currently considered safe induces significant neurobehavioral impairments, including increased anxiety and motor deficits, in Sprague-Dawley rats, with formulation additives and male sex exacerbating these adverse effects.
This study integrates multi-omics and single-cell analyses to demonstrate that polyamine metabolic reprogramming in myeloid cells drives an immunosuppressive microenvironment in lung adenocarcinoma, leading to the identification of the transcriptional regulator ZWINT as a robust prognostic biomarker and therapeutic target.