1504 papers
This study utilizes cryo-electron microscopy to reveal that high light and elevated temperature cause the disassembly of peripheral subunits, the loss of a bicarbonate ligand near the non-heme iron, and a conformational shift in the D1 subunit that may trigger its auto-proteolysis in *Arabidopsis thaliana* Photosystem II complexes.
This study presents a high-quality, haplotype-resolved pangenome of 24 diverse *Eucalyptus grandis* genotypes, revealing extensive structural variation and gene family diversification that uncovers hidden functional plasticity within the conserved lignin biosynthesis pathway.
The paper introduces LognormISI, a data-driven mixture-modeling method that overcomes the limitations of fixed-threshold detectors by identifying statistically separable burst phenotypes in basal ganglia spike trains with high specificity, offering a reproducible framework for analyzing burst-symptom associations in Parkinson's disease.
This study reveals that the association between retinal age gap and systemic diseases is inconsistent across age subgroups due to regression-to-the-mean effects and that model generalisability should be evaluated based on application-specific utility rather than age estimation accuracy alone.
This study utilizes single-nucleus RNA sequencing of postmortem human brain tissue to reveal that while Alzheimer's Disease and primary tauopathies share a conserved cerebrovascular heat-shock stress response, Alzheimer's Disease uniquely exhibits significant vascular remodeling and endothelial dysregulation at AD risk loci, highlighting the vasculature as a potential therapeutic target.
This study demonstrates that reduced LACTB expression in myeloid cells lowers Alzheimer's disease risk by increasing succinylcarnitine levels and enhancing oxidative phosphorylation, positioning LACTB as a promising inflammation-responsive therapeutic target for the disease.
This study of 728 European bats across five Bulgarian hibernacula reveals that while hibernation leads to significant species-, sex-, and roost-dependent declines in body mass and wing integrity alongside reduced ectoparasite loads, it does not cause oxidative deterioration in *Myotis blythii*, as evidenced by decreased DNA damage and altered antioxidant status.
This study reveals that exercise-induced muscle-derived FGF9 drives the hyperplastic expansion of subcutaneous white adipose tissue by activating a specific MGP-positive progenitor cell subset via the FGFR1/MAPK pathway, thereby improving insulin sensitivity and offering a potential therapeutic strategy for diabetes even in the absence of weight loss.
This study synthesizes morphological, molecular, and biochemical analyses of eleven Moroccan *Pistacia lentiscus* populations to reveal high, largely independent diversity across all levels driven by biological traits rather than geography, thereby advocating for the conservation of a broad network of stands, particularly in arid regions.
This study redefines trained immunity by identifying four functionally and epigenetically distinct programs (antibacterial, antiparasitic/pro-allergic, antiviral, and pro-repair) that establish a polarized framework of innate immune memory, demonstrated through specific molecular mechanisms and their differential engagement in human diseases.