1504 papers
This study demonstrates that opioid use disorder is characterized by a blunted catecholaminergic modulation of the brain's hierarchical organization, where methylphenidate fails to compress the principal cortical gradient or improve visual attention in patients compared to healthy controls, suggesting a systems-level deficit linked to the severity and duration of opioid use.
This study integrates single-cell and spatial transcriptomics to reveal that while gastric cancer exhibits widespread transcriptional signatures of tertiary lymphoid structures (TLS), these structures rarely achieve spatial maturity, a deficit that co-occurs with T-cell exhaustion and immunosuppressive signaling, thereby explaining the limited efficacy of immune checkpoint blockade in this disease.
This study demonstrates that the prefrontal cortex asymmetrically modulates distinct auditory-responsive subpopulations in the mediodorsal thalamus, selectively suppressing an anterior group to prolong behavioral reaction times while preserving sensory discrimination accuracy.
This study utilizes comparative transcriptomics to identify specific sets of differentially expressed genes that regulate the induction and maintenance versus the breaking of tuber dormancy in two white yam genotypes across developmental stages.
This study demonstrates that the bile salt sodium glycodeoxycholate modulates chemical barriers in buccal epithelia by inducing molecular membrane reorganisation that drives spatially resolved viscoelastic reconfiguration, revealing that permeation enhancement relies on transient epithelial state transitions rather than simple barrier opening.
This study demonstrates that a novel 1,2,3-triazole derivative (molecule 3) protects HepG2 cells from palmitic acid-induced lipotoxicity by coordinately reducing lipid accumulation, oxidative stress, and inflammation while preserving mitochondrial function and modulating metabolic gene expression, highlighting its potential as a therapeutic agent for metabolic dysfunction-associated steatotic liver disease (MASLD).
This study integrates single-cell and bulk transcriptomic analyses to identify SELENBP1, AK3, and C9orf41 as novel mannose metabolism-related biomarkers in Parkinson's disease, characterizing their downregulation, immune cell associations, and potential therapeutic interactions.
Using acoustic telemetry, this study confirms that southern New Jersey estuaries serve as critical northern nursery habitats for sandbar sharks, characterized by seasonal residency of young-of-the-year and connectivity to coastal migration corridors, which is vital for the conservation of this threatened species as warming temperatures potentially expand their range northward.
This study analyzes 172 Monkeypox virus sequences from Nigeria to reveal that while the virus's transmission dynamics are primarily driven by the year of isolation rather than seasonal factors, Clade IIb has persisted across pre-, during, and post-COVID-19 periods, underscoring the urgent need for standardized surveillance and targeted interventions.
The paper introduces paRDal, a containerized bioinformatics framework that integrates matched germline DNA and RNA NGS data to enhance hereditary cancer diagnostics by detecting splicing and expression abnormalities, thereby improving variant interpretation and diagnostic yield through a user-friendly, evidence-based workflow.