3821 papers
This study identifies MAFF as a protective regulator in osteoarthritis that is downregulated in the disease and functionally mitigates chondrocyte apoptosis and mitochondrial dysfunction through the modulation of stress-response and inflammatory pathways.
This study demonstrates that the predatory soil mite *Blattisocius mali* engages in heterospecific predation on *Stratiolaelaps scimitus* by consuming their eggs and larvae (with preferences varying by life stage and starvation duration), a behavior that could significantly impact biological pest control strategies.
This study reveals that MGAT3-mediated bisecting GlcNAc modification of LAMP1 enhances its stability and recruits ANXA2 to scaffold VAMP8 and STX17 assembly, thereby promoting autophagosome–lysosome fusion and suppressing colorectal tumorigenesis.
This study reveals that cardiac pacemaker cells achieve synchronized rhythmic beating not through traditional electrical coupling, but via a non-canonical mechanism where cyclical fluctuations of extracellular potassium ions in narrow microdomains coordinate and phase-lock the activation kinetics of adjacent cells.
This study of 110 cognitively healthy older adults reveals that while increased self-referential speech is generally associated with poorer episodic memory and executive function, this relationship is significantly strengthened by high levels of repetitive negative thinking, highlighting the importance of psychological factors in natural language biomarkers for cognitive decline.
This study reveals that extrinsic factors like season and trophic level primarily shape the wild marine fish gut microbiome through shifts in microbial abundance, while the intrinsic factor of host species drives phylogenetic community structure via host-specific filtering.
This study demonstrates that 14 days of abstinence from heroin self-administration induces structural remodeling in rat prelimbic cortical neurons projecting to the paraventricular thalamus, specifically increasing mushroom-like dendritic spine density in a manner that correlates with prior drug consumption, thereby providing a structural basis for enduring vulnerability to relapse.
This study demonstrates that the fission yeast *Schizosaccharomyces pombe* can produce a surface-active extract with measurable antibacterial activity against *E. coli* and *S. aureus* when cultivated on low-cost waste substrates of soybean oil and corn steep liquor, though further research is needed to fully characterize the compound and validate its potential.
This study introduces the Canopix® sampling system to demonstrate that the canopy-aerosphere interface constitutes a distinct and ecologically significant habitat for saproxylic beetles, characterized by unique species turnover and resilience to forest dieback, thereby highlighting a previously overlooked vertical dimension of forest biodiversity.
This study characterizes an infectious clone of Papaya virus Q (PpVQ) and evaluates its potential as a virus-induced gene silencing vector, revealing that while the virus can transiently accommodate foreign sequences, it rapidly loses them through deletion, thereby limiting its utility for stable VIGS applications.