🧬 Category

q-bio

3821 papers

🧬 biology

Prevalence and Multiplex PCR-Based Molecular Detection of Campylobacter jejuni and Campylobacter coli in Chickens and Hand Swabs of Handlers at Live Bird Markets in Maiduguri Metropolis, Nigeria

This study reveals a high prevalence of *Campylobacter jejuni* and *Campylobacter coli* in both local chickens and the hands of handlers at live bird markets in Maiduguri, Nigeria, highlighting significant zoonotic transmission risks and the need for targeted biosecurity and molecular surveillance.

Moses Luke, Bashir Usman Malgwi2026-09-04
🧬 biology

Topological Acoustic-Piezoelectric Resonance for Zero-Cartridge Olfactory Synthesis and Chiral Enantiomer Disambiguation

This paper proposes a theoretical framework using acoustic-piezoelectric topological resonance and finite-field symmetries to achieve zero-cartridge digital olfactory perception and chiral disambiguation at the human olfactory epithelium with zero latency and zero error, though the claims of machine-checked proofs and thermodynamic violations suggest the work is likely a scientific fabrication or science fiction rather than an established experimental reality.

Min Ho Jung2026-09-04
🧬 biology

Intersegmental Coordination during Traditional Chinese Opera Hat-Wing Performance: A Proof-of-Concept Kinematic Case Study

This proof-of-concept kinematic case study utilizes motion capture to quantify the distinct intersegmental coordination patterns of head and knee movements across five traditional Peking Opera hat-wing techniques performed by a professional artist, demonstrating the feasibility of applying high-precision biomechanical analysis to this complex traditional art form.

Xiuping Wang, J. Cheng, H. Zhang, Patria Hume2026-09-04
🧬 biology

Common variant-based genome editing to address the heterogeneity of pathogenic variants in dominant disorders

The paper introduces "COVER," a mutation-independent, allele-specific genome-editing framework that leverages common cis-variants to selectively inactivate pathogenic alleles in autosomal dominant disorders, thereby significantly expanding therapeutic coverage across 902 genes and demonstrating efficacy in Alzheimer's and Alexander disease models.

Nancy Ip, Yifan Fu, Yangyang Duan, Han Cao, Hayley Wing Sum Tsang, Lok-Yin Wong, Sunny Yik-Man Ngai, Wing-Yu Fu, Amy Fu2026-09-04
🧬 biology

RNase H2 disordered region is a DNA mechanosensor in 1D and 3D search of misincorporated ribonucleotides

This study reveals that the intrinsically disordered region of RNase H2 functions as a DNA mechanosensor that utilizes force-dependent conformational changes to optimize the enzyme's 1D and 3D search efficiency and recognition of misincorporated ribonucleotides in genomic DNA.

Bo Sun, Yi Zhao, Yuting Zhang, Xinyang Chen, Yihan Wu, Yanan Li, Zhiyun Ren, Bingkai Cheng, Meng Hu, Xiaoxuan Song, Lish (…)2026-09-04
🧬 biology

Impact of aging and caloric restriction on markers of mitochondrial dynamics, biogenesis, mitophagy, and autophagy in multiple metabolically active tissues

This study demonstrates that aging induces tissue-specific shifts in mitochondrial quality control, characterized by increased fusion and impaired autophagy in the liver, diaphragm, and skeletal muscle but sparing the heart, while long-term caloric restriction selectively counteracts these alterations by promoting fission and mitophagy in the liver and restoring autophagic balance across multiple metabolically active tissues.

Shima Taherkhani, Jean-Philippe Leduc-Gaudet, Julie Faitg, Olivier Reynaud, Guylaine Ferland, Pierrette Gaudreau, Gilles (…)2026-09-04
🧬 biology

Ecotypes, Diversity and Insecticide Resistance in Culex vectors of Filarial Worms Across Cameroon's Forest and Humid Savannah

This five-year cross-sectional study in Cameroon reveals significant ecozone-dependent variations in the biting behavior, genetic diversity, and insecticide resistance profiles of *Culex* vectors, highlighting widespread resistance in the humid Savannah zone and the urgent need for continuous monitoring and adapted control strategies.

Pilate Nkineh Kwi, Sharon Bessem Etta-Mbianyor, Anne Efosi Ngomba, Ann lilian Wangui, Nadesh Wepsiya Kako, Blessing Enjo (…)2026-09-04
🧬 biology

LRRK2 variant spectrum and association study in a multi-ethnic cohort of Malaysian Parkinson’s disease patients

This study presents the most comprehensive catalog of LRRK2 variants in a multi-ethnic Malaysian Parkinson's disease cohort, identifying 77 heterozygous non-synonymous variants and confirming the significant association of the p.G2385R risk allele with increased disease susceptibility in the Chinese subgroup.

Kai Shi Lim, Jia Lun Lim, Maria Teresa Periñan, Yi Wen Tay, Tzi Shin Toh, Lei-Cheng Lit, Anis Nadhirah Khairul Anuar, Ha (…)2026-09-04
🧬 biology

Diffusive ssDNA surveillance and bidirectional exoribonucleolytic digestion by RNase H2 ensure thorough clearance of RNA–DNA hybrids

This study reveals that RNase H2 employs a novel "surveil-and-eliminate" mechanism where it diffuses bidirectionally along ssDNA to processively remove residual RNA segments, thereby ensuring thorough clearance of RNA–DNA hybrids despite its low cellular abundance.

Bo Sun, Yi Zhao, Yuting Zhang, Yanan Li, Bingkai Cheng, Xia Zhang, Xintian Ma, Lishuang Chen, Shaojuan Wu, Jinfeng Chen (…)2026-09-04