🧬 biology

Genetic architecture of eating disorder risk and specific symptoms in the general adult population

This study utilizes genome-wide association analyses of 212,000 individuals to demonstrate that eating disorder symptoms in the general population are driven by distinct genetic variants linked to appetite regulation and cognitive-behavioral traits, suggesting that a symptom-based approach offers valuable insights for improving intervention and prevention strategies beyond traditional diagnosis-based methods.

Katri Pärna, Tuuli Sedman, Hanna Kariis, Uku Vainik, René Mõttus, Triin Laisk, Reedik Mägi, Kadri Kõiv, Kelli Lehto2026-07-09
🧬 biology

A mobile platform for magnetoencephalography

This paper presents the first mobile magnetoencephalography (MEG) system, which integrates wearable optically pumped magnetometers with lightweight shielding and battery-powered electronics into a vehicle-mounted scanner to enable high-fidelity, naturalistic brain imaging outside of specialist research centers.

Matthew Brookes, Joseph Gibson, Ewan Kennett, Niall Holmes, Ashley Tyler, Zoe Tanner, Holly Schofield, Ryan Hill, Elena (…)2026-07-09
🧬 biology

Sustained pulvinar activity and early thalamic responses reveal dual temporal dynamics of human attention

By recording intracranial thalamic activity in epilepsy patients, this study reveals that the human pulvinar exhibits distinct temporal dynamics, characterized by a dominant sustained response that supports prolonged attentional states, alongside a less frequent early transient response for rapid stimulus detection.

Francesca Pizzo, Tommaso Biagioni, Victor Lopez-Madrona, Maria Fratello, Giacomo De Nicola, Virginie Laguitton, Roy Haas (…)2026-07-09
🧬 biology

A novel gain of function variant in NUAK2 causes oculomotor apraxia in a three-generation family

This study identifies a novel heterozygous gain-of-function missense variant in the NUAK2 gene as the cause of autosomal dominant congenital oculomotor apraxia and cerebellar vermis hypoplasia in a three-generation family, expanding the gene's known pathogenic mechanisms beyond previously reported loss-of-function variants.

Manjekah Dunn, Janine Smith, Christopher R Horne, Meredith Wilson, Elizabeth Emma Palmer, Samuel N Young, Rocio Rius, Jo (…)2026-07-09
🧬 biology

A Collaborative Framework for Coordinated Analysis Developed by the Genetics of DNA Methylation Consortium

The Genetics of DNA Methylation Consortium (GoDMC) has developed an expanded, community-driven software framework that standardizes cohort-level processing and enables reproducible, summary-statistics-based analyses integrating DNA methylation and genetic variation.

Josine Min, Carlos Ruiz-Arenas, Olalekan Monsir Awoniran, Olivia Castellini-Pérez, Thomas Hendrik Jonkman, Natalia Llong (…)2026-07-09