🧬 biology

Genome-wide association mapping, haplotype analysis and stability mapping of yield-related traits under heat and water-limited stress conditions in bread wheat

This study integrates genome-wide association mapping, haplotype analysis, and stability mapping in a diverse panel of 435 bread wheat genotypes to identify robust genomic regions, favorable haplotypes, and candidate genes associated with yield performance and stability under heat and water-limited stress conditions, providing valuable resources for breeding climate-resilient wheat cultivars.

Neha Neha, Ruchika Sharma, Nishu Raghav, Sonia Sheoran, Nita Lakra, Sanjay Singh, Sarika Jaiswal, Suma Biradar, Lalita J (…)2026-09-03
🧬 biology

Integrated Multi-omics Analysis of the Salivary Microbiome and Metabolome in Gestational Diabetes Mellitus

This study utilizes integrated multi-omics analysis of salivary metabolomics and microbiome data to demonstrate that gestational diabetes mellitus is associated with significant lipid remodeling, metabolic pathway alterations, and distinct shifts in oral microbial composition, supporting saliva as a promising non-invasive resource for GDM biomarker discovery.

Xiaodong Zhu, Bo Zhang, Yuliang Wang, Gang Lei, Wenfang Du, Miaomiao Liu, Lin Cao, Zhen Fu2026-09-03
🧬 biology

Schwann Cell-Derived Paracrine Signaling Drives Temporal Remodeling of the SVF Organoid Microenvironment and Promotes Early-Stage Osteogenic Niche Formation with Neurovascularization

This study demonstrates that RSC96 Schwann cell-derived paracrine signals continuously remodel the microenvironment of adipose-derived SVF organoids, driving the temporal formation of a neurovascularized, early-stage osteogenic niche characterized by synergistic neural, vascular, and extracellular matrix interactions.

En-Dong Luo, Jia-Zhou Wu, Yan-Bin Wu, Ying He, Feng-Fen Guo, Ze-Xian Liu, Jian-Ting Ye, Tao Qian, Ya-Zhou Li, Biao Ma, Y (…)2026-09-03
🧬 biology

POPGEN: building a reference panel of local ancestry to study genetic variability across metropolitan France

The POPGEN project successfully established a representative whole-genome reference panel for metropolitan France by recruiting 15,000 participants based on their grandparents' birthplaces, thereby confirming widespread fine-scale genetic structure and providing a critical resource for improving medical genetics and European population studies.

Emmanuelle Génin, Anthony Herzig, Gaëlle Le Folgoc, Gaelle Marenne, Hélène Blanché, Aude Saint Pierre, Maël Guivarch, Th (…)2026-09-03
🧬 biology

A Promoter Competition Hub Orchestrates Runx1 Alternative Promoter Usage during Skeletal Muscle Stem Cell Activation

This study reveals that a dynamic promoter competition hub, orchestrated by the transcription factor USF1 within a multi-connected enhancer-promoter loop, governs stage-specific alternative promoter usage of the Runx1 gene to regulate skeletal muscle stem cell activation and proliferation.

Huating WANG, Liangqiang He, Qiang Sun, Yulong Qiao, Ziliu Wang, Qin Zhou, Lifang Han, Zhenguo Wu, Hao Sun2026-09-03
🧬 biology

Community-Scale Metabolic Modelling Reveals Coral-Derived Betaine Drives Stress-Associated Microbiome Restructuring

This study demonstrates that stress-induced increases in coral-derived betaine act as a selective metabolic filter that reshapes the fire coral microbiome by favoring betaine-utilizing Alphaproteobacteria over beneficial lineages, thereby driving a nonlinear restructuring toward a specialized community with reduced taxonomic breadth.

Ying Chang, Zhuang Shao, Keegan Lee-Ng, Guohua Zhang, Ming Sheng Ng, Kaiyun Zheng2026-09-03