🧬 Category

q-bio

3821 papers

🧬 biology

Integrative Network Pharmacology, Transcriptomics, scRNA-Seq, Machine Learning, and In Silico Knockout Elucidate Wendan Decoction's Regulatory Mechanisms in Gastric Cancer

This study employs a multi-scale framework integrating network pharmacology, transcriptomics, single-cell RNA sequencing, and machine learning to elucidate how Wendan Decoction targets SPP1 and MMP3 via active compounds like quercetin and berberine to modulate gastric cancer progression and the tumor microenvironment, thereby identifying SPP1 as a high-accuracy diagnostic biomarker and therapeutic target.

Yongzhi Qiao, Liya Liang2026-09-03
🧬 biology

Explainable machine learning to predict depression across phenotype definitions integrating genetic and environmental factors

This study utilizes explainable machine learning on UK Biobank data to demonstrate that depression prediction models and the relative importance of genetic versus environmental factors vary significantly depending on the specific phenotype definition used, with composite lifetime definitions yielding the most stable results and highlighting distinct drivers for current symptoms versus lifetime history.

Bianca Branco, Sam Bentwood, Esme Elsden, Matthew Iveson, Mark Adams, Andrew McIntosh, Peggy Seriès, Heather Whalley, Al (…)2026-09-03
🧬 biology

Microstructural Adaptations of the Ovine Lumbar Disc Annulus to Sustained Axial Compression

This microimaging study of ovine lumbar discs reveals that sustained axial compression differentially deforms the inner and outer annulus, identifying a previously unreported trans-lamellar bridging network in the outer annulus that stiffens the tissue and short-range inter-lamellar fibrous connectivity that reduces shear, thereby challenging current discrete biomechanical models of disc function.

Estella Matthewson, Ashvin Thambyah2026-09-03
🧬 biology

Downregulation of FBXO2 is associated with Aβ aggregation, tau hyperphosphorylation and network impairment in human cortical neurons

This study identifies FBXO2 as a critical transcriptomic regulator in sporadic Alzheimer's disease, demonstrating that its downregulation drives Aβ aggregation, tau hyperphosphorylation, and network impairment in human cortical neurons while revealing associated mitochondrial dysfunction.

Michele Vendruscolo, Alicia Gonzalez Diaz, Andrea Possenti, Gustavo Urritia, Yuqi Bian, Shekhar Kedia, Dorothea Boeken (…)2026-09-03
🧬 biology

Phage-display engineering of cross-reactive CARs for neurofilament light chain

This study demonstrates the proof of concept for engineering cross-reactive chimeric antigen receptors (CARs) that target the intracellular neurofilament light chain (NfL) upon its exposure following cell damage, thereby expanding the scope of CAR therapy to injury-associated antigens.

Valerie Saetzler, Celina M. Hendriks, Tobias Riet, Tom Pieper, Michael Hust, Laura Elisa Buitrago-Molina, Fatih Noyan, E (…)2026-09-03
🧬 biology

Multimodal Cognitive Training and Executive Functions in Public Managers: A Preregistered Randomized Controlled Trial Targeting Working Memory and Inhibitory Control

This preregistered randomized controlled trial demonstrates that a 12-week multimodal cognitive training program significantly improves working memory in public managers, though its effects on inhibitory control appear more heterogeneous and task-specific.

Telesmagno Neves-Teles, Guilherme da Silva Freitas, Cristian Zanon, Rosa Maria Martins de Almeida2026-09-03
🧬 biology

Study on the Effects of Water Deprivation Stress on the Ex-pression of Genes Related to the Glomerular Filtration Barrier in Rabbits

This study demonstrates that acute water deprivation in domestic rabbits induces significant upregulation of glomerular filtration barrier genes (Nephrin and Podocin) and increases urine osmolality, revealing latent adaptive potential that offers comparative insights into the drought tolerance mechanisms of the arid-adapted *Lepus yarkandensis*.

Siquan Liao, Shuai Tian, Bing Chao, Fang Deng, Bu He, Jianping Zhang2026-09-03
🧬 biology

Chronic Liver-Specific LRP1 Silencing Drives Progressive Brain Amyloidosis, Neuroinflammation, and Behavioral Deficits in APP/PS1 Mice

This study demonstrates that chronic, liver-specific silencing of LRP1 in APP/PS1 mice drives a time-dependent progression of Alzheimer's pathology, characterized by the shift from soluble to insoluble brain amyloid-beta, neuroinflammation, and cognitive deficits, thereby establishing the liver as a critical regulator of systemic amyloid-beta clearance and disease progression.

Devaraj V. Chandrashekar, G. Chuli Roules, Urvashi Panchal, Nataraj Jagadeesan, Cody Newhart, Josephine Chu, Brian Carso (…)2026-09-03