1504 papers
This study reveals a significant shared genetic architecture between cataract and major depressive disorder (MDD), characterized by 32 overlapping loci and five candidate genes, suggesting their association stems from pleiotropy rather than a direct causal relationship.
This study identifies a 14-gene Mitoxyperilysis-related signature that independently predicts prognosis in breast cancer by characterizing a distinct tumor microenvironment state marked by innate immune remodeling, myeloid enrichment, and suppressed programmed cell death.
The paper introduces "Spotted," a human-in-the-loop framework that enhances animal re-identification in camera trap surveys by integrating visual similarity with spatio-temporal feasibility priors, significantly improving accuracy for hyenas and leopards while reducing the expert review burden.
This study demonstrates that personality traits significantly moderate the relationship between autonomic regulation (specifically heart rate variability) and psychological stress during virtual reality-mediated communication, suggesting that future digital mental health interventions should be tailored to individual personality profiles.
This study demonstrates that while anthropogenic noise increases swimming speed in Trinidadian guppies, it does not significantly alter their visual antipredator responses, suggesting that visual predatory stimuli drive behavioral changes irrespective of acoustic conditions.
This study employs a systems engineering approach combining classical statistics and machine learning to demonstrate that serum cortisol and temperament (Mizaj) are critical predictors of menstrual cycle dynamics, revealing that Safrawi and Balghami temperaments significantly influence cycle regularity and flow while cortisol and BMI effectively predict pain and regularity.
This study utilizes RNA sequencing to characterize the transcriptomic profiles of *BjGL1*-knockout *Brassica juncea*, revealing that the loss of trichomes leads to significant downregulation of genes involved in secondary metabolite biosynthesis, transport, and defense pathways, thereby elucidating the molecular mechanisms linking trichome formation to plant resistance.
This study characterizes the novel PDC-266 β-lactamase variant in *Pseudomonas aeruginosa*, identifying the N131S substitution as the critical mutation that remodels the active site to confer elevated meropenem resistance while maintaining susceptibility to Avibactam and Sulbactam.
This study identifies SERPINE1 as a critical CAF-associated gene in gastric cancer that drives myCAF phenotype activation via the PI3K-Akt pathway and promotes tumor progression and MDSC infiltration through exosome-mediated mechanisms, highlighting its potential as a therapeutic target.
This study analyzes the plastomes of 54 *Corymbia* species to reveal structurally conserved yet microevolutionarily dynamic genomes, identifying hypervariable regions and confirming the genus's plastid paraphyly through the inclusion of *Angophora costata* within its clades.