3821 papers
This study identifies CDKN2A, XPO1, and TST as core isonicotinoylation-related genes in cervical squamous cell carcinoma that form a highly accurate diagnostic panel and drive tumor progression by regulating cell cycle, metabolic reprogramming, and the immune microenvironment.
This study demonstrates that the transcription factor ERG is essential for maintaining lymphatic endothelial identity and regulating immune cell interactions in the lung, as its downregulation disrupts lymphatic function and promotes inflammation and fibrosis in interstitial lung disease.
This study demonstrates that inhibiting ASC-dependent inflammasome signaling attenuates caspase-1 activation and inflammatory cytokine production, thereby delaying disease progression and extending survival in mouse models of myelodysplastic syndrome, suggesting inflammasome targeting as a potential therapeutic strategy.
Supplementation with ketone esters in aged mice reduces the activation and autoimmune-associated functions of age-associated B cells by directly inhibiting mTORC1 signaling and translation, without compromising the ability to generate antibody responses.
This study demonstrates that combining low-cost medium optimization with EMS-induced random mutagenesis significantly enhances eicosapentaenoic acid (EPA) productivity in the native marine microalga *Microchloropsis salina*, achieving a mutant strain with substantially higher biomass and EPA yields at a fraction of the nutrient cost compared to standard media.
This study provides the first histological assessment of the reproductive biology of Mediterranean horse mackerel (*Trachurus mediterraneus*) in Black Sea coastal waters, revealing asynchronous oogenesis with a batch-spawning strategy, earlier male maturation, and significant regional differences in oocyte size compared to Sea of Marmara populations.
This study documents the endemic slipper lobster *Parribacus perlatus* (Rarape) and two other species on *Porites lobata* reefs in Rapa Nui through morphological and molecular analysis, detailing their distribution, ecology, and reproductive traits to inform scientific management measures against overfishing.
Shotgun metagenomics of an integrated crop-livestock system reveals that while goat manure and soil compartments maintain distinct microbial community structures driven by their specific environments, they share a conserved repertoire of carbohydrate-processing enzymes that lack functional equivalence across these compartments.
This study demonstrates that young ovary-derived blood factors, specifically SFRP4, transfer female cognitive resilience to aged male mice by activating an ovary–bone–brain axis involving osteocalcin to ameliorate age-related cognitive decline.
By applying a reverse-taxonomy approach combining molecular species delimitation with morphological analysis to over 300 globally collected specimens, this study reveals that gossamer worm (Tomopteridae) diversity is significantly underestimated, identifying at least 20 putative species and highlighting the urgent need to revise current taxonomic frameworks for this holopelagic polychaete family.