1504 papers
CXCL12 accelerates peripheral nerve repair by activating the CXCR4/HIF1A/BNIP3 signaling axis to induce mitophagy in Schwann cells, which restores mitochondrial function and enhances the clearance of myelin debris.
This study reveals that while isolated childhood obesity and precocious puberty in girls exhibit distinct gut microbiota alterations, their comorbidity presents a unique microbial profile characterized by a dramatic depletion of Firmicutes and a massive expansion of Verrucomicrobiota, suggesting a specific dysbiotic ecotype that may drive the pathophysiology of this condition.
In small-scale greenhouse shrimp aquaculture systems, the particle-associated microbiome undergoes a temporal shift from stochastic to deterministic assembly, fostering a functionally convergent and cooperative core consortium that ensures efficient nitrogen metabolism despite geographic variations in taxonomic composition.
This study identifies WNT11 as a TGFβ- and canonical WNT/β-catenin-dependent feedback inhibitor that restricts mesenchymal stem cell chondrogenesis via noncanonical pathways, thereby acting as a gatekeeper that limits SOX9 activity to facilitate progression toward chondrocyte hypertrophy.
This study presents the first comparative genomic analysis of *Burkholderia pseudomallei* isolates from Bangladesh, revealing that while core virulence systems are conserved, clinical outcomes may be influenced by distributed functional mutations in regulatory and stress-response pathways rather than a single dominant virulence determinant.
This study demonstrates that Sophora davidii flower (SDF) exerts anti-aging effects on HUVECs by inhibiting senescence and enhancing tube formation through the dose-dependent regulation of the TP53-PI3K/AKT signaling pathway, as revealed by network pharmacology and experimental validation.
This study identifies SCP2 as a novel independent prognostic and immunological biomarker for colorectal cancer, demonstrating that its downregulation correlates with poor clinical outcomes, advanced disease stages, an immunosuppressive microenvironment, and enhanced tumor cell proliferation.
By utilizing activity sensor data to track oestrus in wild European roe deer, this study reveals that mating is highly synchronized and largely independent of individual traits, suggesting that reproductive phenology is primarily driven by the timing of delayed implantation rather than conception dates.
This study characterizes the distinct mucosa-associated microbial profiles of North Indian patients with ulcerative colitis, revealing a unique dysbiosis marked by an elevated Firmicutes-to-Bacteroidota ratio, specific taxonomic shifts, and altered microbial interaction networks compared to healthy controls.
This study demonstrates that the repurposed drugs desloratadine and zinc gluconate act as effective efflux pump inhibitors that synergize with erythromycin to restore its efficacy against multidrug-resistant bacteria both in vitro and in a mouse model, a mechanism further validated by molecular docking and simulation studies targeting the AbeJ protein.