3821 papers
Two newly isolated *Clostridium butyricum* strains, XMC 312 and SWY 13, alleviate dextran sulfate sodium-induced colitis in mice by restoring intestinal barrier integrity, enhancing antioxidant defenses, modulating gut microbiota composition, and increasing short-chain fatty acid production.
This study utilizes transcriptomic analysis to demonstrate that toxin-antitoxin systems in *Helicobacter pylori* are dynamically regulated in response to acid stress, suggesting their critical role in the bacterium's survival within the harsh gastric environment.
By analyzing long-term census data from the Tibetan Plateau, this study reveals that while forest biodiversity generally enhances carbon stocks, the specific trajectories and mechanisms of this relationship diverge significantly across different forest biomes and successional stages, driven by the dynamic interplay between stand structural development and complexity.
This study demonstrates that while integrating transcriptomic data with whole-slide histopathology images improves glioblastoma survival prediction across various encoders, including state-of-the-art foundation models, these foundation models did not consistently outperform a standard ImageNet-pretrained ResNet50 baseline in this limited-size, frozen-encoder setting.
This study utilizes integrative transcriptome analysis and machine learning to identify a coordinated ceRNA network in chemoresistant triple-negative breast cancer that drives resistance through the convergence of immune evasion, pathological angiogenesis, and transcriptional reprogramming.
This study utilized bioinformatics analysis and in vitro validation to identify a three-gene ferroptosis-related signature (GLS2, TFRC, and EPSA1) that serves as an independent prognostic predictor for nasopharyngeal carcinoma, correlating significantly with clinical characteristics and enriched in specific biological pathways.
This study demonstrates that despite taxonomic differences driven by substrate type, hydrocarbon seep biofilms across diverse natural and artificial surfaces converge on a conserved functional organization where complementary methane- and sulfur-oxidizing guilds sustain specialized heterotrophic communities through partitioned metabolic roles and interactions.
This study demonstrates that nitrate enrichment in larval habitats enhances the physiological resilience and metabolic reserves of *Aedes aegypti* mosquitoes while simultaneously reducing their susceptibility to permethrin, thereby threatening the efficacy of insecticide-based vector control strategies.
This study reveals that the invasive slug *Ambigolimax valentianus* is restricted to urban habitats because its reliance on spatial avoidance of predator cues, rather than effective chemical defense against the native beetle *Carabus yaconinus*, renders it highly vulnerable to predation compared to the native slug *Meghimatium bilineatum*.
This study demonstrates that while ZooMS can successfully identify pig bone proteins heated up to approximately 200°C, subsequent resin impregnation significantly reduces peptide recovery and can compromise taxonomic identification.