3821 papers
This study reveals that preterm birth involves a heterogeneous multi-layered fetal genomic architecture characterized by distinct rare variant profiles and non-coding de novo mutations, which are best understood by integrating clinical variability into a continuous phenotype rather than relying on overall mutational burden.
This paper introduces a novel, reproducible framework that applies Eulerian, place-based spatial point pattern analysis to avian tracking data, enabling the precise identification of behavioral states and critical habitats across multiple scales while complementing traditional trajectory-based approaches.
This study reveals that tirzepatide promotes weight loss in mice by activating a distinct brainstem circuit (AP→DMV→RPa) that drives brown adipose tissue thermogenesis independently of appetite suppression, a mechanism that accounts for approximately 40% of its efficacy and is not effectively engaged by semaglutide.
This study reveals that while wildfire ash deposition does not deter the feeding behavior of the specialist herbivore *Manduca sexta*, it significantly impairs fitness by slowing growth, increasing mortality, and depleting lipid reserves, thereby threatening ecosystem functioning through disrupted plant-herbivore interactions.
This study reveals that overweight maritime workers exhibit distinct gut microbiota dysbiosis and altered lipid metabolism compared to their normal-weight counterparts, suggesting that targeted dietary and microbiota interventions could help manage weight in this population.
This trio-based whole-exome sequencing study of 36 early-onset high myopia families identifies a 61.1% diagnostic yield driven largely by de novo mutations, reveals that genetic burden significantly correlates with fundus lesion severity rather than refractive error, and suggests an oligogenic additive inheritance model involving genes related to visual perception, photoreceptor cilium assembly, and extracellular matrix remodeling.
This study developed a novel 3D in vitro model using decellularized Wharton's Jelly to demonstrate that the bone marrow extracellular matrix induces chemoresistance, dormancy, and increased tumorigenicity in CD133-positive prostate cancer stem cells, particularly within the DU145 cell line.
This study of the Danish National Birth Cohort identifies a reproducible perinatal steroid signature characterized by reduced levels of neuroactive steroids like allopregnanolone and pregnenolone in umbilical cord blood, alongside altered complement and extracellular matrix signaling, which is associated with a later diagnosis of autism.
The study presents PoxSTG, a chimeric oncolytic poxvirus developed through directed evolution that overcomes systemic delivery barriers by evading immune neutralization, enhancing tumor spread via syncytial fusion, and inducing immunogenic cell death to achieve potent antitumor efficacy.
This study demonstrates that reductive soil disinfestation (RSD) using biogas residues and slurry effectively mitigates antibiotic resistance genes (ARGs) by leveraging volatile fatty acid dynamics to drive a bacterial community succession from ARG-enriched *Firmicutes* to *Proteobacteria*, ultimately disrupting the co-localization of ARGs with mobile genetic elements.