1514 papers
This genome-wide association study identifies both established and novel genetic variants that significantly modulate cerebrospinal fluid, plasma, and urine biomarkers in α-synucleinopathies, highlighting the critical need to account for genetic background when interpreting these biomarkers for diagnosis and therapeutic development.
This study demonstrates that analyzing the distinct, cell-type-specific inflammatory signatures of macrophage-derived osteopontin and cardiomyocyte-derived NLRP3 in forensic autopsy hearts provides valuable insights into the inflammatory microenvironment of acute ischemic heart disease, potentially aiding the diagnosis of sudden death cases with subtle pathological findings.
This study demonstrates that a recombinant multi-epitope vaccine targeting sperm proteins IZUMO1, SACA3, and PH-20 effectively reduces fertility in female mice by inducing significant antibody responses that impair fertilization, all while maintaining a safe short-term histopathological profile.
This study demonstrates that a higher proportion of lifetime rural living experience is independently associated with reduced rapid naming performance and slower processing speed in cognitively normal Chinese older adults, highlighting a significant, underrecognized source of environmental bias in language-based cognitive assessments.
This study elucidates that the transcription factor OsDERF1 enhances rice resistance to the nematode *Hirschmanniella mucronata* by repressing the expression of the negative regulator OsWD40-193, which interacts with ABF95813 to suppress resistance via the jasmonic acid signaling pathway.
This study demonstrates that a parameter-efficient adaptation of the MUSK vision foundation model using Low-Rank Adaptation not only achieves high diagnostic accuracy for gastric cancer in a resource-constrained Chilean cohort but also enables a novel allometric ecological framework that quantifies tumor morphotype heterogeneity while mathematically correcting for sampling biases to improve patient stratification.
This study establishes a scalable, patient-derived clonal cerebral organoid model harboring the R270X mutation that recapitulates key molecular and functional deficits of Rett syndrome, thereby providing a robust platform for mechanistic insights and therapeutic evaluation.
This ten-year analysis of over 7,000 Olympic-distance triathlon records utilizes a human-in-the-loop generative AI workflow to identify the run leg as the primary performance discriminator, assess heat resilience, and develop a digital twin prototype for optimizing race planning and heat-strain management.
This study establishes a robust high-cell-density fed-batch process in *E. coli* that, through the optimization of induction timing, temperature, and host-strain combinations, achieves yields exceeding 2.5 g/L of functional anti-CD45 nanobodies, with periplasmic secretion proving superior to cytoplasmic production in terms of yield, thermal stability, and folding uniformity.
This study provides the first empirical evidence that the emergence of devil facial tumour disease has driven the adaptive loss of a specific MHC-I locus and a reduction in MHC diversity in Tasmanian devils, reshaping their immune gene architecture to enhance tumour resistance while potentially compromising future resilience to other pathogens.