🧬 Category

q-bio

3821 papers

🧬 biology

Genome-Guided Computational Profiling of Selected Antibiotics for Repurposing against Multiple Resistance Proteins in Multidrug-Resistant Stenotrophomonas maltophilia

This study utilizes an integrated computational workflow, including homology modeling, molecular docking, and molecular dynamics simulations, to identify kanamycin C as the most promising cross-target candidate for interacting with key resistance proteins (AAC(6′)-Ib4, DfrA14, and L1 metallo-β-lactamase) in multidrug-resistant *Stenotrophomonas maltophilia*, thereby generating testable hypotheses for antibiotic repurposing while emphasizing that these findings remain predictive rather than clinically confirmed.

Hajar Fauzan Ahmad, Md. Shaon Mia, Md. Nazim Uddin, Elias Ali, Roney Miah, Shing Wei Siew2026-09-02
🧬 biology

Absence of active Equine Herpesvirus Type 1 detected by qPCR in asymptomatic high-risk horses from

A study of 111 unvaccinated horses in southern Brazil participating in high-risk equestrian events found no evidence of active Equine Herpesvirus Type 1 infection via qPCR, highlighting the importance of continuous molecular surveillance to manage outbreak risks in stressed populations.

José Luiz Avila Terra, Larissa Mallmann, Nilson Júnior da Silva Nunes, Eduarda Lima Pereira, Vitória Bandeira, Ana Carol (…)2026-09-02
🧬 biology

Shotgun Metagenomic Characterization of the Gut-Content Microbiota of Kronopolites svenhedini

This study presents the first shotgun metagenomic characterization of the gut-content microbiota of the millipede *Kronopolites svenhedini*, revealing a bacterial community dominated by Pseudomonadota and Actinomycetota that harbors a diverse repertoire of carbohydrate-active enzymes (CAZymes) with potential for lignocellulose degradation, thereby establishing a baseline for future functional and ecological research.

Yaning Li, Yan Dong, Jiajia Wang2026-09-02
🧬 biology

Recurrent Sleep Restriction During Aging Induces Early Recognition Memory Impairment, Neuroinflammation, and Blood–Brain Barrier Dysfunction in Female Wistar Rats

Recurrent sleep restriction throughout the aging process in female Wistar rats accelerates age-related cognitive decline by inducing blood-brain barrier dysfunction and neuroinflammation, although its impact on cellular senescence varies by age and brain region.

Ana B. Ramírez-López, Jessica J. Avilez-Avilez, Beatriz Gómez-González, Verónica Salas-Venegas, Ricardo Jair Ramírez-Car (…)2026-09-02
🧬 biology

Added value of molecular karyotype to isolated increased nuchal translucency: report of 1,104 genomic investigations

This retrospective study of 1,104 fetuses with isolated increased nuchal translucency demonstrates that while adding chromosomal microarray to conventional karyotyping increases the detection of pathogenic copy number variations by approximately 3.4%, it also introduces a significant rate of variants of uncertain significance (6.4%) that require continuous re-evaluation and integrated cytogenetic approaches for accurate prenatal counseling.

Redaelli Serena, Zanatta Valentina, Sala Elena, Villa Nicoletta, Crosti Francesca, Bertola Francesca, Francesca Malvesti (…)2026-09-02
🧬 biology

A conserved structural organization of the human public TCRβ repertoire persists throughout exceptional longevity

This study establishes a conserved structural atlas of the human public TCRβ repertoire composed of 64 Structural Sequence Modules, demonstrating that exceptional longevity preserves this higher-order organization while selectively remodeling the quantitative occupancy of these pre-existing compartments rather than replacing or losing them.

Luigi Buonaguro, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Biancamaria Cembrola, Simona Mangano, Ana Mendi (…)2026-09-02
🧬 biology

Systems-level remodeling of lifelong antiviral antibody repertoires distinguishes physiological aging from breast cancer

This study utilizes high-throughput serological profiling to demonstrate that while physiological aging drives a coordinated expansion of lifelong antiviral antibody repertoires, breast cancer is characterized by increased reactivity and selective redistribution of existing responses, revealing distinct systems-level trajectories of immune remodeling between the two conditions.

Beatrice Cavalluzzo, Biancamaria Cembrola, Simona Mangano, Alessandra Calabrese, Michelino De Laurentiis, Angela Mauriel (…)2026-09-02