3821 papers
This study demonstrates that older adults with insomnia disorder exhibit high-load working memory deficits linked to reduced frontoparietal control network connectivity and impaired glymphatic function, with the latter moderating the relationship between neural connectivity and cognitive performance.
This study elucidates a multistep mechanism for bacterial feather degradation by *Streptomyces* sp. G11C, revealing that oxidoreductase-mediated disulfide bond reduction and structural destabilization precede and facilitate the action of specific proteases, thereby offering new insights for sustainable keratin valorization.
This study demonstrates that HIV–tuberculosis coinfection profoundly remodels CD4⁺ T-cell differentiation trajectories and disrupts adrenal hormonal balance, while revealing that dehydroepiandrosterone (DHEA) can partially, though not fully, restore the effector/memory phenotype of Mtb-responsive T cells toward a healthy profile.
Although physical and observational motor sequence learning yield comparable behavioral outcomes even when learning is interrupted, they rely on partially distinct post-training neural adaptations, with physical practice engaging motor-striato-cerebellar feedback loops and observational learning recruiting fronto-cerebellar and episodic memory networks.
This study elucidates the molecular mechanism of human phosphatidylethanolamine methylation by presenting five cryo-EM structures of PEMT that reveal its substrate recognition, ordered catalytic cycle, cofactor gating, and the inhibition mechanism of the drug clofibric acid, thereby establishing a structural foundation for developing selective PEMT modulators.
This study presents TANSR-Vax, a computationally guided self-amplifying RNA–lipid nanoparticle vaccine that successfully overcomes immune exclusion and stromal suppression in hepatocellular carcinoma by integrating neoantigen priming with tumor microenvironment reprogramming, resulting in enhanced T-cell activation and significant tumor regression in preclinical models.
This study demonstrates that the rapid urban expansion of the non-native Southern Small White butterfly (*Pieris mannii*) in Central Europe is driven by the synergistic interaction between the high availability of non-native ornamental host plants in cities and the species' intrinsic preference for dispersing within urban habitats.
This study demonstrates that analyzing clade-specific Relative Evolutionary Rate (RER) shifts offers a powerful complementary approach to traditional dN/dS methods for detecting site-level adaptations, particularly by revealing biologically meaningful signals of past adaptive events followed by intensified purifying selection that standard metrics often miss.
Chronic high-salt intake induces persistent, sex-specific metabolic alterations in aging mice that are not fully reversed by dietary salt reduction, with females retaining a distinct metabolomic signature despite blood pressure normalization, suggesting metabolic dysregulation represents an additional layer of cardiovascular risk beyond hypertension.
This study demonstrates that reduced SIRT3 expression promotes GPX4 acetylation, leading to ferroptosis-related endothelial senescence and vascular aging, while SIRT3 overexpression mitigates these effects by deacetylating GPX4 and restoring mitochondrial function.