🧬 Category

q-bio

1582 papers

🧬 biology

Temporal shift toward deterministic assembly shapes particle‑associated core microbiome for cooperative nitrogen metabolism in small-scale greenhouse shrimp aquaculture systems

In small-scale greenhouse shrimp aquaculture systems, the particle-associated microbiome undergoes a temporal shift from stochastic to deterministic assembly, fostering a functionally convergent and cooperative core consortium that ensures efficient nitrogen metabolism despite geographic variations in taxonomic composition.

Ni Liu, Zhiyuan Yan, Yuxing Xie, Hao Long, Xiaoni Cai, Aiyou Huang, Yanhua Zeng, Zhenyu Xie2026-07-09
🧬 biology

WNT11 is a TGFβ- and WNT/β-catenin-dependent feedback inhibitor of mesenchymal stem cell chondrogenesis

This study identifies WNT11 as a TGFβ- and canonical WNT/β-catenin-dependent feedback inhibitor that restricts mesenchymal stem cell chondrogenesis via noncanonical pathways, thereby acting as a gatekeeper that limits SOX9 activity to facilitate progression toward chondrocyte hypertrophy.

Solvig Diederichs, Malina Krüger, Valentina Trivigno, Svitlana Melnik, Helen Dietmar, Moritz Innmann, Wiltrud Richter2026-07-09
🧬 biology

Clinicogenomic Insights into Burkholderia pseudomallei Reveal Functional Variants Associated with Clinical Outcomes in Bangladesh

This study presents the first comparative genomic analysis of *Burkholderia pseudomallei* isolates from Bangladesh, revealing that while core virulence systems are conserved, clinical outcomes may be influenced by distributed functional mutations in regulatory and stress-response pathways rather than a single dominant virulence determinant.

Lovely Barai, Ismat Ruh Jahan, Senzuti Sharmin, Mili Rani Saha, Tanjila Rahman, Md. Rokibul Hasan, Noshin Ibnat Rib, Fah (…)2026-07-09
🧬 biology

Utilizing network pharmacology and experimental validation to investigate the underlying mechanism of Sophora davidii resists aging

This study demonstrates that Sophora davidii flower (SDF) exerts anti-aging effects on HUVECs by inhibiting senescence and enhancing tube formation through the dose-dependent regulation of the TP53-PI3K/AKT signaling pathway, as revealed by network pharmacology and experimental validation.

Bin Deng, Zhigang Ju, Chenggang Hu, Angxin Song, Shuai Liu, Zongren Xu, Yingyi Yu2026-07-09
🧬 biology

It’s now or never: mating is highly synchronised in a monestrous ungulate

By utilizing activity sensor data to track oestrus in wild European roe deer, this study reveals that mating is highly synchronized and largely independent of individual traits, suggesting that reproductive phenology is primarily driven by the timing of delayed implantation rather than conception dates.

Agathe Culioli, L. Monica Trondrud, Nadège C. Bonnot, Jean-Michel Gaillard, Benjamin Rey, Jean-François Lemaître, A. J. (…)2026-07-09
🧬 biology

Ulcerative Colitis Is Associated with Distinct Colonic Mucosa-Associated Microbial Profiles in a North Indian Cohort

This study characterizes the distinct mucosa-associated microbial profiles of North Indian patients with ulcerative colitis, revealing a unique dysbiosis marked by an elevated Firmicutes-to-Bacteroidota ratio, specific taxonomic shifts, and altered microbial interaction networks compared to healthy controls.

Arpita Bhatt, Usha Dutta, Amit Arora, Balvinder Mohan, Neelam Taneja2026-07-09
🧬 biology

Restoring erythromycin efficacy by the repurposed drugs desloratadine and zinc gluconate as adjuvants via bacterial efflux pump inhibition

This study demonstrates that the repurposed drugs desloratadine and zinc gluconate act as effective efflux pump inhibitors that synergize with erythromycin to restore its efficacy against multidrug-resistant bacteria both in vitro and in a mouse model, a mechanism further validated by molecular docking and simulation studies targeting the AbeJ protein.

Rukunuzzaman Mia, Chandan Barai, Rafat Hossain Rafi, Anamul Haque, Md. Abdul Alim Al-Bari2026-07-09