3821 papers
This study demonstrates that preconditioning human adipose-derived mesenchymal stromal cells with citrate-coated maghemite nanoparticles in a scalable microcarrier culture system generates MRI-detectable extracellular vesicles that exhibit enhanced, magnetically amplifiable immunomodulatory activity for potential image-guided therapies.
This study demonstrates through computer modeling that the diprotonated inorganic phosphate (H₂PO₄⁻) is kinetically equivalent to inorganic phosphate (Pi) as a fatigue factor in skeletal muscle, suggesting both can be treated as components of a single "super-metabolite" responsible for fatigue-related properties during exercise.
This study demonstrates that three cyanobacterial species exhibit distinct tolerance levels and carotenoid modulation patterns under lead and cadmium stress, with *Phormidium autumnale* showing the highest resilience and *Oscillatoria subbrevis* the greatest sensitivity, highlighting species-specific physiological responses relevant to bioremediation.
This study validates the patent-pending Biotex Autologous Exosome Purification Kit as an effective, ultracentrifugation-free single-step method for isolating high-purity, morphologically and immunophenotypically confirmed autologous exosomes from human peripheral blood, offering a superior alternative to conventional isolation techniques.
By integrating serum lipidomics, renal transcriptomics, and Mendelian randomization, this study establishes that glycerophospholipid dysregulation is a causal, systemic phenotype in calcium oxalate kidney stones, linking elevated circulating phosphatidylethanolamine and sphingolipid levels to increased stone risk through shared metabolic pathways with renal tissue pathology.
This study establishes a robust, high-efficiency protoplast isolation and PEG-mediated transfection system using bud-stage flower petals and tissue-cultured leaves of *Lycoris*, enabling rapid gene functional analysis, alkaloid quantification, and protein interaction studies to overcome the genus's long regeneration cycle and advance its molecular breeding and pharmaceutical applications.
This study demonstrates that TXNL1 is overexpressed in pancreatic ductal adenocarcinoma and drives malignant progression, including proliferation, invasion, and EMT, by activating the MEK/ERK and PI3K/AKT signaling pathways, thereby identifying it as a promising prognostic biomarker and therapeutic target.
This study of 196 Chinese children and adolescents reveals that higher subjective well-being, particularly driven by engagement, is associated with reduced resting-state functional connectivity and lower global network integration, suggesting that a more economical brain architecture supports healthy psychological flourishing.
This study identifies five tick species and detects novel and emerging pathogens, including the first reported circulation of *Uukuvirus tachengense* and *Rickettsia kotlanii* in the Iberian Peninsula, by analyzing ticks collected from Iberian wolves, thereby highlighting the wolf's role as a sentinel for ecosystem health.
This study demonstrates that repeated oral exposure to tenuazonic acid in rats induces significant, dose-dependent cytokine alterations with both monotonic and non-monotonic patterns, while comparative reanalysis of acute exposure reveals distinct inflammatory profiles, with Orthogonal Implicit Projection analysis serving as a valuable tool for interpreting these coordinated biomarker responses.