3821 papers
This combined post-mortem and 7T fMRI study demonstrates that tau deposition patterns within the medial temporal lobe are significantly shaped by the intrinsic functional connectivity of the entorhinal and perirhinal cortices, suggesting that network organization drives tau propagation even before amyloidosis.
This study demonstrates that curcumin-loaded solid lipid nanoparticles (SLN-Cur), engineered via a Quality-by-Design framework, exhibit high biocompatibility and induce cell-type-specific modulation of immuno-redox and angiogenic pathways in trophoblasts, promoting a protective phenotype in healthy cells while showing an inverted response in dysfunctional models.
This study demonstrates that the Gem gene is widely expressed at both the mRNA and protein levels across various brain regions of adult Kunming mice, with particularly strong protein localization observed in hippocampal, cerebellar, brainstem, and olfactory bulb neurons.
This study of South Indian women identified a suggestive regional signal at the MTNR1B locus associated with prediabetes and demonstrated that while a European-derived polygenic risk score shows a significant association with the condition, its predictive accuracy remains weak, underscoring the need for ancestry-specific models.
This study presents a continental-scale synthesis of standardized phospholipid fatty acid (PLFA) data from 11,399 soil samples across 47 National Ecological Observatory Network (NEON) sites, accompanied by an open-source R workflow and Shiny application that reveal strong latitudinal gradients in microbial community composition and provide unprecedented resources for investigating soil microbial biogeography.
This paper introduces RE-FLIM, a fluorescence-lifetime encoding technique that overcomes the quadratic scaling limitations of previous methods to achieve single-protein-resolution imaging, enabling the visualization of individual HIV-1 Env trimer protomers in intact cell membranes.
This study validates that the all_ratio algorithm, a four-dimensional weighted scoring system, enables rapid, accurate, and simultaneous detection of pathogenic bacteria, fungi, and antibiotic resistance genes in nanopore metagenomic data, effectively overcoming the limitations of traditional methods by identifying low-abundance pathogens and achieving precise gene-host matching.
This study identifies a reproducible, immune-active transcriptional program, specifically the "Allograft rejection" pathway, that is consistently associated with favorable neoadjuvant treatment response across multiple rectal cancer cohorts, although the current signature lacks sufficient discriminatory power for immediate clinical prediction.
This study utilizes multi-tissue transcriptome analysis to identify genome-wide regulatory signatures and specific cis-regulatory loci, particularly within immune-related pathways, that underlie gene expression differences between in vitro produced (IVP) and multiple ovulation and embryo transfer (MOET) derived bovine calves.
This study identifies the RNA-binding protein PvPUF1 as a key molecular regulator of *Plasmodium vivax* hypnozoite persistence by linking it to a specific RNA motif and the CCR4–NOT deadenylation complex, while also revealing that hypnozoites reside in a distinct, transcriptionally quiescent host microenvironment.