3822 papers
This systematic review evaluates computer vision methods for fine-grained behavioral phenotyping in Autism Spectrum Disorder, highlighting their potential for severity assessment and differential diagnosis while identifying critical gaps in standardized datasets, evaluation metrics, and longitudinal research.
This study reveals that low ambient temperature promotes the accumulation and early recruitment of the histone demethylase ELF6, which works redundantly with JMJ13 to remove repressive H3K27me3 marks from floral repressors like FLM and FLC, thereby fine-tuning flowering time in response to cold.
This study benchmarks five Vision Transformer architectures for predicting MYC status in Diffuse Large B-cell Lymphoma, revealing that while the Swin Transformer offers superior speed and risk stratification, the Hierarchical ViT achieves the highest diagnostic accuracy, thereby establishing a mathematically validated framework for optimizing architectural trade-offs in digital pathology.
This study demonstrates that a salinity-driven enrichment strategy combined with rational design of synthetic bacterial consortia significantly enhances rice growth and salt stress tolerance by leveraging synergistic interactions that improve strain colonization and persistence compared to single-strain inoculations.
This study demonstrates that the dietary fiber raffinose is a critical determinant for maintaining the intestinal persistence of beneficial bifidobacteria after weaning, thereby promoting disease resistance and reducing inflammation in adult mice.
This study establishes a comprehensive genomic catalog of 2,096 human gut archaea to reveal global variations and identify specific species and syntrophic interactions associated with inflammatory bowel disease, thereby providing a high-resolution framework for integrating the archaeome into precision medicine.
This study demonstrates that *Phthorimaea operculella* larvae adapt to the toxic effects of the potato-derived alkaloid α-solanine by activating midgut-mediated glycolipid metabolism, which involves upregulating catabolic enzymes and downregulating biosynthetic pathways to facilitate detoxification and maintain survival.
This study demonstrates that *Trichinella spiralis* infection ameliorates colitis by reshaping the gut microbiota to enrich *Bacteroides acidifaciens*, which produces ursodeoxycholic acid (UDCA) that binds to TGR5 receptors on dendritic cells and macrophages to inhibit NLRP3 inflammasome activation, reduce inflammatory cytokines, and restore intestinal barrier integrity.
This study identifies CPOX and SLC35F5 as key downregulated biomarkers for depression and anxiety in obesity through integrated bioinformatic analysis and experimental validation, revealing their association with Toll-like receptor signaling and proposing subtype-specific therapeutic candidates like mazindol and FK-866.
By applying multivariate, Bayesian, and clustering approaches to International Mouse Phenotyping Consortium data, this study identifies 59 novel hearing loss genes and establishes a methodological framework that significantly enhances the sensitivity and specificity of large-scale auditory gene discovery compared to traditional univariate analyses.