3826 papers
This study identifies CPOX and SLC35F5 as key downregulated biomarkers for depression and anxiety in obesity through integrated bioinformatic analysis and experimental validation, revealing their association with Toll-like receptor signaling and proposing subtype-specific therapeutic candidates like mazindol and FK-866.
By applying multivariate, Bayesian, and clustering approaches to International Mouse Phenotyping Consortium data, this study identifies 59 novel hearing loss genes and establishes a methodological framework that significantly enhances the sensitivity and specificity of large-scale auditory gene discovery compared to traditional univariate analyses.
This study reveals that NiONPs-induced pulmonary fibrosis is driven by the hsa_circ_0007702/miR-181d-5p/SLC7A11 axis, where upregulated hsa_circ_0007702 suppresses miR-181d-5p to increase SLC7A11, thereby inhibiting disulfidptosis and promoting collagen deposition, suggesting that targeting this axis to suppress disulfidptosis could serve as a novel therapeutic strategy for pulmonary fibrosis.
This study fine-mapped a major Ascochyta blight resistance locus in the lentil accession ILL7537 to a 2.05 Mbp region, identified five candidate resistance genes including NBS-LRRs and an ethylene response factor, and developed tightly linked markers to facilitate precise breeding for disease control.
This paper proposes a conceptual, reduced-form model demonstrating that incorporating fungal cocolonizers into landfill biocovers can shift the system's dynamics out of a bistable failure window caused by contamination, thereby enabling reliable methane capture in degraded sites where bacteria-only systems fail, provided the fungal hazard-suppression effect exceeds a critical threshold.
This study reveals that specific compensatory mutations in the hemagglutinin of Italian H7N1 avian influenza viruses enabled the virus to adapt to poultry hosts and evade immune detection through antigenic drift, while strictly maintaining avian receptor specificity and failing to enhance replication in human cells.
This study demonstrates that an aqueous bark extract of the Saudi medicinal plant *Acacia ehrenbergiana* is biocompatible and significantly accelerates the migration and wound closure of human periodontal ligament fibroblasts in vitro, supporting its potential use as a natural agent in periodontal regenerative medicine.
This study employs an information-theoretic clustering framework based on Kullback–Leibler cluster entropy to analyze the structural organization of specific human genes involved in epigenetic regulation and neurodevelopmental disorders, demonstrating that the resulting entropy profiles are robust and useful for comparative genomics and functional gene characterization.
This study demonstrates that the molecular signature of dopaminergic degeneration in the Parkinsonian substantia nigra corresponds to a specific gene expression program localized to inner-retinal neurons, particularly amacrine and ganglion cells, thereby providing a defined molecular substrate for retinal changes in Parkinson's disease.
This study demonstrates that intrauterine infusion of platelet-rich plasma (PRP) or platelet-poor plasma (PPP) in mares susceptible to persistent breeding-induced endometritis differentially modulates early embryonic gene expression, with PRP enhancing cellular homeostasis and PPP promoting developmental regulation and energy metabolism, indicating that these therapies influence the embryonic transcriptome via endometrial effects independent of platelet concentration.