🧬 Category

q-bio

1582 papers

🧬 biology

Biological costs associated with metabolic and target-site insecticide resistance in Anopheles gambiae: evidence from the E205D-CYP6P3 and L995F-kdr markers in field populations from Cameroon

This study demonstrates that in *Anopheles gambiae* populations from Cameroon, metabolic resistance (E205D-CYP6P3) and target-site resistance (L995F-kdr) impose distinct, stage-specific fitness costs that lead to the rapid decline of target-site mutations but the persistence of metabolic resistance under relaxed insecticide pressure, highlighting the need for mechanism-tailored resistance management strategies.

Magellan Tchouakui2026-07-08
🧬 biology

Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation

This study demonstrates that inhibiting DNA demethylation with Bobcat339 attenuates experimental necrotizing enterocolitis in neonatal mice by suppressing TLR4-mediated inflammation, suggesting a promising therapeutic strategy for this condition.

Yukihiro Yamaguchi, Vikram Puri, Corey M. Jania, Olivia G. Cassidy, Lauren R. Bolzan, Gergely D. Mozes, Ethan A. Brown (…)2026-07-08
🧬 biology

Urban encounters between Jaguars, Pumas, and humans reported through Citizen Science in Brazil

Based on citizen science data from 2016 to 2025, this study reveals that urban conflicts between humans and jaguars or pumas in Brazil are relatively rare but concentrated in the Southeast and Central-West regions, with pumas being the primary species involved, highlighting the urgent need for targeted management strategies to mitigate human-wildlife overlap.

Herlina Paula da Silva e Silva, Maria Beatriz Bezerra Castro, Jéssica Lobato Peixoto, Igor Araújo Barbosa, Rogério Fonse (…)2026-07-08
🧬 biology

Direct Current Electric Field-Induced Membrane Permeabilization and Apoptosis in HeLa Cells: Fluorometric Quantification of Biphasic Dose-Dependent Kinetics via Acridine Orange/Ethidium Bromide Dual Staining

This study demonstrates that sustained low-intensity direct current electric fields induce a voltage-dependent, biphasic apoptotic response in HeLa cells via controlled membrane permeabilization, characterized by a hormetic viability recovery at intermediate doses and a shift from early to late apoptosis at higher intensities, while largely suppressing necrosis.

Afdhal Muttaqin, Tuti Lestari, Yulkifli, Tofrizal, Ibrahim, Abdul Fadhilla Deshafa2026-07-08
🧬 biology

Colloid-Osmotic Swelling Acts as an Upstream Trigger for Electro-Apoptosis in HeLa Cells Exposed to Low-Intensity Direct Current

This study demonstrates that low-intensity direct current induces colloid-osmotic swelling in HeLa cells, which acts as an upstream physical trigger distorting mitochondrial function to initiate regulated electro-apoptosis rather than necrosis, offering a new biophysical framework for optimizing bioelectric cancer therapies.

Afdhal Muttaqin, Tuti Lestari, Tofrizal, Ibrahim, Abdul Fadhilla Deshafa2026-07-08
🧬 biology

Optimization of the complex lyoprotectant composition for the high viability of Penicillium chrysogenum ACCC 30395 conidia

This study utilized Response Surface Methodology with a Box-Behnken design to optimize a complex lyoprotectant formulation of skim milk, sucrose, and glycerol, successfully achieving a high viability rate of 85.73% for lyophilized *Penicillium chrysogenum* ACCC 30395 conidia, which closely matched the model's predicted value.

Myong-Gyong Pae, Chung-Jin Choe, Thae-Sok Kang, Tong-Ryul Kim, Tae-Gil Kim, Chol-Song Kim, Hye -Gyong Mun, Jong-Su Kim (…)2026-07-08
🧬 biology

In vivo transcriptome analysis of the entomopathogenic fungus Beauveria bassiana strain GHA during infection against the beneficial predator tobacco leaf bug, Nesidiocoris tenuis (Hemiptera: Miridae)

This study utilized comparative in vivo transcriptome analysis of *Beauveria bassiana* strain GHA at distinct infection stages to identify upregulated virulence genes involved in cuticle penetration and hemocoel colonization during its infection of the beneficial predator *Nesidiocoris tenuis*, offering a strategy to address the fungus's unintended toxicity to this biological control agent.

Oumi Nishi2026-07-08
🧬 biology

Comprehensive Bioinformatics Investigation of RAD51C in Cervical Cancer: Expression, Prognostic Significance, DNA methylation, Immune Infiltration, Immune Checkpoint Correlation, and Functional Network Analysis

This bioinformatics study reveals that RAD51C is significantly overexpressed in cervical cancer and linked to DNA repair and cell-cycle pathways, yet it does not serve as a significant prognostic marker or correlate with major immune checkpoint genes despite showing specific associations with certain immune cell infiltrates.

Emmanuel Owusu Frimpong, Paul Boabeng2026-07-08
🧬 biology

Transcriptome profiling of neurexin- and neuroligin-deficient Caenorhabditis elegans reveals pathways underlying developmental and behavioral dysfunction

This study demonstrates that neurexin and neuroligin deficiency in *C. elegans* causes widespread transcriptional reprogramming affecting diverse pathways beyond synaptic function, thereby linking molecular dysregulation to the observed developmental, behavioral, and neuromorphological abnormalities.

Omamuyovwi Ijomone, Victor Anadu, Toheeb Oyerinde, Olayemi Ijomone, David Oyeniran, Michael Aschner2026-07-08✓ Author reviewed ⓘ
🧬 biology

Biallelic mutations in SUPV3L1 cause a variable leukodystrophy due to impaired mitochondrial degradosome function

This study defines the clinical and radiological spectrum of a variable leukodystrophy caused by biallelic SUPV3L1 mutations, demonstrating that the loss of this mitochondrial degradosome component leads to neurodevelopmental impairment and microcephaly through the dysregulation of type I interferon signaling.

Lydia Green, Noémie Hamilton, Marilena Elpidorou, Reza Maroofian, Maha S. Zaki, Andrew G.L. Douglas, Katrin Õunap, Ailsa (…)2026-07-08