3829 papers
This study employs an information-theoretic clustering framework based on Kullback–Leibler cluster entropy to analyze the structural organization of specific human genes involved in epigenetic regulation and neurodevelopmental disorders, demonstrating that the resulting entropy profiles are robust and useful for comparative genomics and functional gene characterization.
This study demonstrates that the molecular signature of dopaminergic degeneration in the Parkinsonian substantia nigra corresponds to a specific gene expression program localized to inner-retinal neurons, particularly amacrine and ganglion cells, thereby providing a defined molecular substrate for retinal changes in Parkinson's disease.
This study demonstrates that intrauterine infusion of platelet-rich plasma (PRP) or platelet-poor plasma (PPP) in mares susceptible to persistent breeding-induced endometritis differentially modulates early embryonic gene expression, with PRP enhancing cellular homeostasis and PPP promoting developmental regulation and energy metabolism, indicating that these therapies influence the embryonic transcriptome via endometrial effects independent of platelet concentration.
This study of 57 parks in arid Isfahan, Iran, demonstrates that avian biodiversity is primarily shaped by structurally complex, high-density canopy networks rather than park size or human disturbance alone, with species-specific occupancy responses varying significantly across distinct habitat gradients.
This multi-database bibliometric analysis of global research from 2016 to 2025 reveals a rapidly expanding, interdisciplinary field centered on oxidative stress and environmental factors affecting male fertility, with China and the US as leading contributors and future directions pointing toward epigenetic mechanisms, emerging pollutants, and biomarker development.
This study demonstrates that 10-HDA, a key component of royal jelly, ameliorates autism-like behaviors in mice by restructuring the gut microbiota to suppress IL-6, which subsequently downregulates the methylase Kmt2b to remodel bivalent histone landscapes and promote the epigenetic commitment of Tregs, thereby restoring immune balance and social function.
This study demonstrates that urban and rural house sparrows are similarly susceptible to low pathogenicity H7N9 avian influenza, but natural co-infection with Avipoxvirus significantly increases the prevalence and persistence of both viruses, highlighting a critical ecological interaction that may influence the birds' role as bridge hosts for influenza transmission.
This study employs a prospectively specified, cryptographically frozen audit to demonstrate that while radius-3 Morgan fingerprints effectively distinguish enantiomers, their ability to predict measured same-assay enantioselectivity under scaffold extrapolation is real but strongly target-dependent, yielding significant results for only a subset of targets while others show null or negative predictive skill.
This study demonstrates that while wearable-based stress classifiers for hospital nurses may show high internal accuracy, their performance significantly degrades when evaluated on unseen individuals, highlighting the critical need for participant-level validation to ensure transportability before operational use.
This multi-omics study reveals that breast cancer and type 2 diabetes share immunometabolic mechanisms driven by CLEC7A-associated myeloid immune reprogramming and the MIF–CD74/CXCR4 signaling axis, offering new insights into their cross-disease inflammatory communication and potential therapeutic targets.