1582 papers
This study identifies PTEN downregulation and NOTCH1 upregulation as conserved molecular signatures of oral squamous cell carcinoma across distinct Indian populations (Gujarat and Telangana), suggesting their potential as robust, geography-independent biomarkers for the disease.
This study identifies phosphorylation of ribosomal protein S6 at Ser235 and increased IL-6 release in peripheral blood mononuclear cells as a distinct inflammatory signature that correlates with clinical severity and distinguishes manifesting Parkinson's disease from non-manifesting states across both idiopathic and LRRK2-associated forms.
This paper proposes and validates a smoothed successive Kullback-Leibler divergence of degree distributions as an effective early-warning signal for critical transitions in power-law networks, demonstrating its ability to detect impending collapse earlier than traditional connectivity measures under random node removal while providing immediate disruption summaries under targeted attacks.
This cross-sectional study of children with spastic diplegic cerebral palsy reveals that while altered prefrontal cortex EEG activity correlates with social function, vestibulo-ocular reflex parameters do not directly associate with motor or functional performance, highlighting the multifactorial nature of motor impairment in this population.
This study utilizes metagenomic sequencing across coastal water, bivalves, and marine mammals to demonstrate that filter-feeding bivalves serve as effective integrative sentinel hosts for monitoring diverse and dynamic viral communities, thereby supporting One Health surveillance and early detection of zoonotic risks.
GenPTM is a generalized, BiomedBERT-based framework that overcomes the limitations of PTM-specific tools by using a unified text representation strategy to accurately extract protein modification events and sites from scientific literature across a wide range of PTM types.
Although adult zebrafish hearts rapidly recover their electrical function following acute severe hypoxia, transcriptomic analysis reveals that significant molecular remodeling and stress responses persist for at least seven days, demonstrating that functional recovery does not equate to immediate molecular normalization.
This study presents the first complete mitochondrial genome of the Amazonian fish parasite *Clinostomum dimorphum*, generated via hybrid sequencing to resolve complex regions, and reveals conserved genomic features alongside lineage-specific evolutionary patterns that clarify phylogenetic relationships within the Clinostomidae family.
NatCodon is a generative model that leverages protein structural information to optimize codon sequences for co-translational folding, significantly outperforming existing frequency-based methods by strategically deploying rare codons to enhance soluble protein yields and enable the expression of previously intractable targets.
This paper presents a unified deep learning system that utilizes ConvNeXt-V1 to automatically classify animal species and detect foot injuries from static track images, achieving high accuracy in a 12-class setting and demonstrating that injury detection is particularly effective when decoupled from species discrimination.