Sequential Causal Normal Form Games: Theory, Computation, and Strategic Signaling

This paper extends Causal Normal Form Games to sequential settings by introducing Sequential Causal Multi-Agent Systems, but its comprehensive theoretical and empirical analysis reveals that, under standard rational assumptions, these causal frameworks offer no welfare advantage over classical Stackelberg equilibrium, thereby highlighting a fundamental incompatibility between rational choice and causal reasoning benefits in current game-theoretic models.

Dennis ThummThu, 12 Ma📊 stat

Controlling the joint local false discovery rate is more powerful than meta-analysis methods in joint analysis of summary statistics from multiple genome-wide association studies

This paper proposes a novel summary-statistics-based joint analysis method that controls the joint local false discovery rate (Jlfdr), demonstrating through simulations and empirical data that it offers superior power over traditional meta-analysis methods, particularly when analyzing heterogeneous genome-wide association study datasets.

Wei Jiang, Weichuan YuThu, 12 Ma📊 stat

Don't Disregard the Data for Lack of a Likelihood: Bayesian Synthetic Likelihood for Enhanced Multilevel Network Meta-Regression

This paper proposes a Bayesian Synthetic Likelihood (BSL) framework integrated with Hamiltonian Monte Carlo to enhance Multilevel Network Meta-Regression by leveraging available subgroup-level summary statistics to impute missing individual-level covariates, thereby improving population-adjusted treatment comparisons in the presence of incomplete data.

Harlan Campbell, Charles C. Margossian, Jeroen P. Jansen, Paul GustafsonThu, 12 Ma📊 stat

A Model-Based Restricted Shapley Value to Measure the Players' Contribution to Shot Actions in Football

This paper introduces a novel framework combining the expected Goal Action (xGA) metric with a Player's Restricted Shapley (PRS) statistic to quantify individual player contributions in football shot actions by modeling team interactions through tactically admissible passing coalitions, as demonstrated in an analysis of the 2022/23 Serie A season.

Mattia Cefis, Rodolfo Metulini, Maurizio CarpitaThu, 12 Ma📊 stat

Bayesian Optimization with Gaussian Processes to Accelerate Stationary Point Searches

This paper presents a unified Bayesian optimization framework using Gaussian processes with derivative observations and advanced extensions like Optimal Transport and random Fourier features to efficiently accelerate the search for minima and saddle points on potential energy surfaces, bridging theoretical formulation with practical implementation through accompanying Rust code.

Rohit Goswami (Institute IMX and Lab-COSMO, École polytechnique fédérale de Lausanne)Thu, 12 Ma📊 stat

Causal Survival Analysis in Platform Trials with Non-Concurrent Controls

This paper develops a causal survival framework for platform trials that demonstrates while pooling non-concurrent controls can improve precision under strict assumptions, the most robust approach to avoid bias and maintain efficiency is to target concurrent causal estimands using covariate-adjusted doubly robust estimators that rely solely on concurrent controls.

Antonio D'Alessandro, Samrachana Adhikari, Michele SantacatterinaThu, 12 Ma📊 stat

Estimands and the Choice of Non-Inferiority Margin under ICH E9(R1)

This paper demonstrates that under the ICH E9(R1) framework, the choice of a non-inferiority margin must be explicitly aligned with the specific estimand, as variations in intercurrent event strategies and historical trial designs significantly influence the estimated treatment effect and the validity of the constancy assumption.

Tobias Mütze, Helle Lynggaard, Sunita Rehal, Oliver N. Keene, Marian Mitroiu, David WrightThu, 12 Ma📊 stat

Risk time splitting for improved estimation of screening programs effect on later mortality

This paper details and extends a refined mortality estimation method for evaluating cancer screening programs by incorporating maximum likelihood estimation and Poisson regression offsets to utilize all available data, thereby significantly improving statistical precision and producing narrower confidence intervals compared to traditional approaches.

Harald Weedon-Fekjær, Elsebeth Lynge, Niels KeidingThu, 12 Ma📊 stat

Bayesian Design and Analysis of Precision Trials with Partial Borrowing

Motivated by a gastric cancer trial, this paper proposes a Bayesian framework for precision clinical trials that utilizes individually weighted external data to partially borrow information for estimating subgroup effects, supported by a simulation study comparing its performance to dynamic borrowing and demonstrating its application in determining sample sizes and decision boundaries.

Shirin Golchi, Satoshi MoritaThu, 12 Ma📊 stat