Epigenetic perturbation unravels diverse origins, state conversions and de-differentiation of cortical astrocytes
This study reveals that the epigenetic modifier DOT1L acts as a critical barrier regulating cortical astrogenesis by orchestrating transcription factor networks that control astrocyte state conversion, de-differentiation, and the emergence of diverse astrocyte populations originating from both dorsal and ventral telencephalic lineages.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of a preprint that has not been peer-reviewed. It is not medical advice. Do not make health decisions based on this content. Read full disclaimer
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