Reversible inhibition of medial septum interneurons abolishes initial acquisition of new place-reward associations and reveals a progressive reduction in dependence on medial septal function

This study demonstrates that while reversible inhibition of medial septum interneurons initially abolishes the acquisition of new place-reward associations, repeated training in a stable environment allows mice to overcome this deficit by shifting from a hippocampus-dependent spatial strategy to a non-hippocampal visual pattern-matching solution.

Original authors: Alizadeh, Z., Ferbinteanu, J., Eckert, M., Shobe, J., McDonald, R., McNaughton, B.