Cytokine storm dynamics in hantavirus pulmonary syndrome: a multiscale ODE model with Wasserstein early-warning score and application to the 2026 Andes virus outbreak
This paper presents a multiscale ODE model of the 2026 Andes virus outbreak on the MV Hondius that identifies a critical immunopathological feedback loop as the driver of fatal cytokine storms, proposing a Wasserstein-based early-warning score and exogenous IL-10 supplementation as the most effective intervention to prevent vascular permeability failure.