📄 medicine

Clinical, cerebrospinal fluid, and microbiological characteristics of childhood purulent meningitis at a tertiary pediatric hospital in Vietnam: a retrospective study

这项针对越南一家三级医院102名儿童的回顾性研究表明,化脓性脑膜炎主要影响五岁以下的儿童,临床表现常不具备典型的脑膜刺激征,且尽管整体微生物学确认率较低,但最常见的病原体仍是肺炎链球菌。

Tung Cao Viet, Huong Le Thi Lan, Nam Dao Huu, Ly Pham Ha, Thuy Ha Minh, Khiem Nguyen Van2026-07-14
📄 medicine

From Adversity to Suicidality: Differential Effects of ACE Subtypes on Suicidal Thoughts and Behaviors among Adolescents in the United States

本研究利用具有全国代表性的 2023 年 YRBS 数据揭示,虽然特定的不良童年经历(ACE)亚型(如性虐待和情感忽视)显著增加了美国青少年出现自杀念头和行为的风险,但这些风险又因持续的悲伤而加剧,并因种族和族裔群体而异,从而凸显了对具有文化响应性且基于创伤知情的干预措施的需求。

Philip Baiden, Batholomew Chireh, Sheriffa Mahama, Raymond Glikpo, Judith Anagbonu, Vera Mets, Helena Baffoe2026-07-14
📄 medicine

The Chain-Mediating Roles of Fear of Cancer Recurrence and Insight Between Self-Disgust and Rehabilitation Exercise Adherence in Patients with Malignant Bone Tumors

这项针对266例恶性骨肿瘤患者的横断面研究表明,自我厌恶通过涉及癌症复发恐惧和洞察力的独立及序列中介路径,对康复训练依从性产生负面影响,这提示整合心理与认知干预可能有助于改善长期康复效果。

Qin Yu, Xiaofeng Yin, Qiuru Wang, Ying He, Ye Li, Xiaoyan Liu2026-07-14
📄 medicine

The effects of food safety guidelines in comparison to the neutropenic diet on infection rates and nutritional status in patients with acute myeloid leukemia undergoing remission induction chemotherapy: a randomized clinical trial

这项随机临床试验发现,对于接受诱导化疗的急性髓系白血病成年患者,遵循食品安全指南与限制性中性粒细胞减少饮食相比,其感染率和营养结果相似,同时提供了一种负担更轻且依从性更高的饮食方式。

Yasaman Hosseini, Sajjad Moradi, Faramarz Jalili, Shirley Hodder, Sahar Tavakkoli Shiraji, Seied Asadollah Mousavi, Hoss (…)2026-07-14
📄 medicine

Reproducing comparative therapeutic efficacy in relapsed refractory multiple myeloma using an external control arm derived from historical clinical trial data

本研究表明,利用倾向评分匹配法构建的由协调后的历史临床试验数据组成的外部对照臂,能够准确重现复发/难治性多发性骨髓瘤随机对照试验中观察到的总生存期治疗效应,从而支持了在具备高质量患者级数据时使用此类方法的效用。

Xiang Yin, Mehmet Burcu, Mark D. Stewart, Elizabeth Stuart, Ruthanna Davi2026-07-14
📄 medicine

Magnitude and determinants of leprosy-related stigma among persons affected by leprosy and community contacts in southern Benin: a mixed-methods study

这项在贝宁南部开展的混合方法研究揭示了受影响个体及社区接触者均承受着沉重的麻风相关污名化负担,并指出主动筛查、诊断延迟以及农村居住地是关键决定因素,这使得有必要采取针对性的、具有文化敏感性的干预措施,以减轻心理社会后果。

Fifamin Noël Christelle GBAGUIDI, Sètondji Diane ZANVO, Sonagnon Inès Elvire AGBO, Sèdjro Gimatal Esaï ANAGONOU, Karine (…)2026-07-14
📄 medicine

Geographic Differences and Their Influence on Tolvaptan Treatment in Patients with ADPKD

这项在土耳其开展的多中心回顾性研究表明,地理和气候因素,特别是高温和长时间日照,显著影响了常年累月受累的常年性多囊肾病(ADPKD)患者对托伐普坦的耐受性和生化反应,这提示应考虑环境参数进行个体化剂量调整,以提高安全性并改善依从性。

Sibel Gokcay Bek, Ismail Kocyigit, Kadir Gökhan Atılgan, Emre Aydın, Sibel Balcı, Özgür Akın Oto, Dilek Gibyeli, Tolga Y (…)2026-07-14