📄 medicine

The Bridlington Eye Assessment Project Age-related Macular Degeneration Study (BEAP-AMD2): Characterising Phenotype-Genotype Associations in a UK Population Cohort

这项针对 55 岁及以上英国人群的前瞻性横断面研究,表征了年龄相关性黄斑变性(AMD)的患病率及其与第 1 号和第 10 号染色体上特定遗传变异的关联,揭示了尽管视网膜和脉络膜厚度随 AMD 严重程度而进行性下降,但这些结构性变化与遗传风险仅呈现出相关性的趋势,而这种趋势在其他高加索人群队列中也得到了验证。

Winfried Amoaku, Christian Pappas, Richard Gale, Vittorio Silvestri, Laura Cushley, Jill Hageman, Reuben Amoaku, Rukhsar (…)2026-07-07
📄 medicine

Associations of Voluntary and Required Group Physical Activity with Depressive Symptoms Among Chinese Adolescents: A Cross-sectional and Longitudinal Approach

这项研究表明,虽然自愿性的体育活动与中国青少年抑郁症状的减少具有强关联性,但强制性的团体体育活动在横断面研究中并未显示出益处,且在纵向研究中与抑郁症状的增加相关,尤其是在女孩群体中。

Yuru Du, Jianqiang Wang, Zheng Liu, Siyuan Chen, Youdong Li2026-07-07
📄 medicine

Cardiorenal Stress Phenotype, Renal Recovery, and Survival Outcomes in Newly Diagnosed Multiple Myeloma with Renal Impairment: A Real-World Cohort Study

这项真实世界队列研究表明,新诊断的伴有肾功能不全的多发性骨髓瘤患者表现出一种以 NT-proBNP 和 LDH 升高为特征的独特心肾应激表型,这种表型独立预测了异质性的肾功能恢复和较差的总生存期,提示仅凭血液学反应不足以进行预后评估,且心肾应激分层应被纳入临床管理。

Xiaoyan Liu, Jie Xiao, Xiuju Wang, Danian Nie, Chouxia Zhao, Dana Feng2026-07-07
📄 medicine

Value-Based Healthcare Model of Medical and Pharmaceutical Care for Patients With Coronary Artery Disease with Comorbid Conditions: Cost- Benefit Analysis in the Healthcare Setting of Ukraine

本研究提出并验证了一种针对患有冠心病及共病症状的乌克兰患者的基于价值的三级药物护理模型,并通过成本效益分析证明,整合临床药师与原研固定剂量复方制剂能显著减少心血管事件,并在多个医疗保健视角下产生巨大的净经济效益。

Natalia Bilousova, Tamara Mahanova, Natalia Tkachenko, Vasyl Mykhalchuk, Nataliia Kozhuharyova, Maryna Dolzhenko2026-07-07
📄 medicine

Detecting tumor-associated peptides from the plasma-derived soluble immunopeptidome in human hepatocellular carcinoma patients: a pilot study

这项初步研究表明,肝细胞癌患者血浆来源的可溶性 HLA-I 多肽包含与肿瘤组织共享的肿瘤相关抗原,这表明 sHLA-I 分析谱图是识别可干预靶点和肿瘤特异性特征的一种具有前景的微创策略。

Amy L. Kessler, Yannick S. Rakké, Lisa Bokhout, Robbie J. Luijten, Wouter A.S. Doff, Karel Bezstarosti, Roel F.A. Pieter (…)2026-07-07
📄 medicine

Temporal Inverted Internal Limiting Membrane Flap Technique versus Conventional Internal Limiting Membrane Peeling Technique for Large Macular Holes: A Retrospective Comparative Study

这项回顾性比较研究表明,对于大直径全层黄斑裂孔,与传统的内界膜剥离术相比,时间反转内界膜瓣技术在视力、外层视网膜层恢复以及闭合率方面(特别是针对直径≥550 µm的黄斑裂孔)具有更优越的表现。

Sule Acar Duyan, Gülay Güler Canözer, Şaban Gönül2026-07-07
📄 medicine

30-Day Morbidity and Mortality of Surgical Management for Lower Limb Vascular Injury in Yemeni Civilians: A Prospective Cohort Study

这项针对 78 名患有下肢血管损伤的也门平民进行的前瞻性队列研究显示,30 天死亡率为 9%,发病率为 51.3%,并确定血流动力学不稳定是死亡的主要预测因子,而伴随性神经损伤是功能恢复的决定性因素,同时强调了改进院前分诊和外科转运的紧迫需求。

Aref Ali Al-Hashedi, Mohammed Ali Eissa, Nabeel Yahiya Al-Madwahi, Haitham Mohammed Jowah2026-07-07