📄 医学

Alagille Syndrome: A Comprehensive Review of Clinical Heterogeneity, Genetic Mechanisms, and Evolving Therapeutic Strategies

本综述通过详细阐述 Alagille 综合征高度多变的全身系统临床表现、 Notch 通路病理机制以及从多学科协作护理到新兴靶向疗法的不断演进的管理策略,对这一由 JAG1 或 NOTCH2 基因突变引起的罕见常染色体显性遗传病进行了全面审查。

Foram Khamar, Dulari Shah, Manav Kanani, Keval Patel, Bisojeet Khandai2026-10-21
📄 医学

Geographic Mobility of Hematology–Oncology Fellows and Its Association with Regional Cancer Care Disparities in the United States

这项研究表明,美国的血液肿瘤科专科培训医生表现出显著的地理流动性,倾向于向高收入且种族多样性较低的地区迁移,这一趋势加剧了癌症护理的不平等,但可能通过在从专科培训向执业过渡阶段实施针对性干预得到缓解。

Rushabh Sheth, Sohawm Sengupta, Chakravarthy Nulu, Vishwanath Anil, Raag Patel, Malek Moumne, Daylen Lomeli, Bradley Coa (…)2026-10-21
📄 医学

FloTrac®-guided haemodynamic resuscitation for profound cefuroxime-induced anaphylactic shock after induction of anaesthesia for cervical spine surgery: a case report

本病例报告表明,通过精确追踪每搏输出量变异度、体循环血管阻力指数及心指数,实时 FloTrac® 指导下的血流动力学监测,使一名在麻醉诱导后出现严重的头孢呋喃诱发性过敏性休克患者得以成功进行目标导向的液体与血管收缩剂复苏。

Kamarol Salleh, Wan Mohd Nazaruddin Wan Hassan2026-10-21
📄 医学

Enhancing competency-based dermatology and venereology education for undergraduate medical students in Burundi medical schools: A modified Delphi study

本研究采用了一种改良的两轮德尔菲技术,通过专家小组对 42 项核心能力进行验证并建立课程体系,旨在加强布隆迪医学生在皮肤病学和性病学方面的教育。

Axel Keza, Epipode Ntawuyamara, Mustafa Mohammad Khaleel MT Khasawneh, Jean Claude Mbonicura, Daniel Nduwayo, Dieudonné (…)2026-10-21
📄 医学

Drug quantification in single 3D organoids reveals correlation to reported in vivo brain uptake and demonstrates translational relevance for prediction of blood-brain barrier permeability

本研究通过 UPLC-MS/MS 验证了一种定量的 3D 人类血脑屏障(BBB)类器官模型,证明其药物摄取率与体内脑血比显著相关,并在评估血脑屏障通透性方面优于现有的计算机模拟预测工具。

Cindy Bay, Meike Kästing, Jiayi Chu, Eric Mühlberg, Camilo Scherkl, Philipp Uhl, Julia Carolin Stingl, Jürgen Burhenne (…)2026-10-21
📄 医学

Effectiveness of an experiential on-site education intervention on food safety knowledge, attitude and practices among street food vendors in Nairobi’s informal settlements

一项在内罗毕非正规定居点进行的准实验研究表明,一种特定于情境的现场教育与支持性监督干预显著改善了街头食品摊贩的食品安全态度与实践,尽管并未产生显著的知识变化。

David Osogo, Antonina Mutoro, Daniel Osuka, Maureen Gitagia, Calistus Wilunda, Dickson Amugsi, Dasel Wambua Mulwa-Kaindi (…)2026-10-21