📄 medicine

Reduced FOXP3 Expression by Flow Cytometry Is a Functional Biomarker in IPEX Syndrome: Clinical, Structural and Therapeutic Correlations from a Brazilian National Cohort

这项针对巴西 IPEX 综合征队列的研究表明,尽管调节性 T 细胞频率与健康对照组重叠,但显著降低的 FOXP3 平均荧光强度(MFI)可作为一种稳健的诊断功能生物标志物,其与关键蛋白结构域中的特定致病变异相关,并能指导治疗干预。

Leonardo Oliveira Mendonça, Amanda Melato Oliveira, Sandra Maria Monteiro, Maria Lúcia Carnevale Marin, Mauricio Gomes P (…)2026-09-03
📄 medicine

Cost-Effectiveness of a Locally Manufactured 3D-Printed AI-Assisted Videolaryngoscope: A Model-Based Economic Evaluation

这项基于模型的经济学评估表明,在巴西公共医疗系统中,一种本地制造、3D打印且具备AI辅助功能的视频喉镜,是替代用于气道管理的进口金标准设备的严格占优、具有成本节约性且更有效的方案。

Ana Cristina Beitia Kraemer Moraes, Inês Moraes Hirdes, Larissa Oliveira Daneluz, Marcelo Vieira Rodrigues, Andressa da (…)2026-09-03
📄 medicine

CD105-assessed microvessel density and recurrence and progression in non-muscle- invasive bladder cancer: a retrospective cohort study

这项针对157例非肌层浸润性膀胱癌患者的回顾性队列研究得出结论,CD105评估的微血管密度并不能预测复发,且相较于临床风险因素无法提供增量价值,同时由于事件数量有限,其与疾病进展的相关性似乎与肿瘤分级无法区分。

Ahmet Selimoğlu, Akif Türk, Mete Ucdal, Mustafa Yücel Boz, Alper Kafkaslı2026-09-03
📄 medicine

Site-specific reference ranges and reproducibility of myocardial native T1, T2 and T2* mapping at 3T in healthy adults: a prospective Australian single-centre study

这项前瞻性单中心研究确立了特定部位的参考范围,并证明了在健康澳大利亚成年人中,3T磁共振下心肌原生T1、T2和T2*测绘具有良好至极佳的重现性,同时识别出这些数值在性别和年龄方面存在显著差异。

Augustine Mugwagwa, Robert Gluer, Panorea Hudson, Cecily Hunt, John Younger2026-09-03
📄 medicine

Effects and Potential Active Ingredients of a HAPA-Based Parent-Focused Intervention on Parental Support for Children’s 24-Hour Movement Behaviors: A Randomized Controlled Trial

这项随机对照试验表明,一项为期12周、基于健康行动过程模型(HAPA)且以家长为中心的干预措施,通过改变特定的心理社会决定因素,显著改善了家长支持以及儿童的轻度身体活动、中高强度身体活动和久坐屏幕时间,其中“意图”是这些行为中共同的有效成分。

Wei Liang, Shenjiao Zhong, Jiayu Chen, Hanxiao Zhu, Yanping Duan, Ryan E. Rhodes, Ning Su, Lin Zhou, Chunbo Qin2026-09-03
📄 medicine

Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomic Study of Peripheral Blood Mononuclear Cells in Patients With Psoriatic Arthritis

本研究利用基于液相色谱-质谱(LC-MS)的代谢组学和网络药理学技术,表征了银屑病关节炎患者外周血单个核细胞中独特的代谢重编程,揭示了亚型及活动度特异性的代谢特征,鉴定了潜在的诊断生物标志物,并证实了 IL-17 抑制剂治疗能有效逆转特定的代谢异常。

Ruihong Hou, Xingxing Zhao, Yazhen Su, Liyun Zhang2026-09-03
📄 medicine

Association between Lamina Terminalis Fenestration and Shunt-Dependent Chronic Hydrocephalus After Ruptured Anterior Circulation Aneurysms: A Single-Center Retrospective Cohort Study

这项单中心回顾性研究发现,在针对破裂性前循环动脉瘤进行显微夹闭术的过程中,终末板窗状化与减少分流依赖性慢性脑积水之间不存在统计学上的显著关联,尽管其研究结果受到选择偏倚、样本量较小以及置信区间较宽的限制。

Okay Baykara, Faruk İldan, Metin Tuna, Kerem Mazhar Özsoy, Ali Ufuk Keçebaş, Halil Emre Alcan2026-09-03
📄 medicine

Association Between Fetal Fraction and Positive Predictive Value of Noninvasive Prenatal Testing for Sex Chromosome Aneuploidies: A Retrospective Study of 68,290 Cases

这项针对 68,290 例病例的回顾性研究表明,虽然无创产前检测(NIPT)对性染色体非整倍体的阳性预测值因亚型而异,但胎儿游离分数是真实阳性结果的一个独立预测因子,且具有明确的剂量效应关系,而孕妇年龄和双胎妊娠则未显示出显著相关性。

Zhuangping Zhang, Jiexia Yang, Xinni Shu, Haishan Peng, Fangfang Guo, Dongmei Wang, Tingting Hu, Yaping Hou2026-09-03