📄 medicine

The effects of food safety guidelines in comparison to the neutropenic diet on infection rates and nutritional status in patients with acute myeloid leukemia undergoing remission induction chemotherapy: a randomized clinical trial

这项随机临床试验发现,对于接受诱导化疗的急性髓系白血病成年患者,遵循食品安全指南与限制性中性粒细胞减少饮食相比,其感染率和营养结果相似,同时提供了一种负担更轻且依从性更高的饮食方式。

Yasaman Hosseini, Sajjad Moradi, Faramarz Jalili, Shirley Hodder, Sahar Tavakkoli Shiraji, Seied Asadollah Mousavi, Hoss (…)2026-07-14
📄 medicine

Reproducing comparative therapeutic efficacy in relapsed refractory multiple myeloma using an external control arm derived from historical clinical trial data

本研究表明,利用倾向评分匹配法构建的由协调后的历史临床试验数据组成的外部对照臂,能够准确重现复发/难治性多发性骨髓瘤随机对照试验中观察到的总生存期治疗效应,从而支持了在具备高质量患者级数据时使用此类方法的效用。

Xiang Yin, Mehmet Burcu, Mark D. Stewart, Elizabeth Stuart, Ruthanna Davi2026-07-14
📄 medicine

Magnitude and determinants of leprosy-related stigma among persons affected by leprosy and community contacts in southern Benin: a mixed-methods study

这项在贝宁南部开展的混合方法研究揭示了受影响个体及社区接触者均承受着沉重的麻风相关污名化负担,并指出主动筛查、诊断延迟以及农村居住地是关键决定因素,这使得有必要采取针对性的、具有文化敏感性的干预措施,以减轻心理社会后果。

Fifamin Noël Christelle GBAGUIDI, Sètondji Diane ZANVO, Sonagnon Inès Elvire AGBO, Sèdjro Gimatal Esaï ANAGONOU, Karine (…)2026-07-14
📄 medicine

Geographic Differences and Their Influence on Tolvaptan Treatment in Patients with ADPKD

这项在土耳其开展的多中心回顾性研究表明,地理和气候因素,特别是高温和长时间日照,显著影响了常年累月受累的常年性多囊肾病(ADPKD)患者对托伐普坦的耐受性和生化反应,这提示应考虑环境参数进行个体化剂量调整,以提高安全性并改善依从性。

Sibel Gokcay Bek, Ismail Kocyigit, Kadir Gökhan Atılgan, Emre Aydın, Sibel Balcı, Özgür Akın Oto, Dilek Gibyeli, Tolga Y (…)2026-07-14
📄 medicine

Workplace Interventions to Improve Physical Activity, Reduce Sedentary Behavior, and Promote Healthy Diet Among Employees in Low- and Middle- Income Countries: A Systematic Review

这项针对六个中低收入国家、涵盖16项研究的系统评价表明,尽管存在高流失率和现有文献中存在中度至高度偏倚风险等挑战,但多组分职场干预是改善员工心血管风险特征最有效的策略。

Samina Akhtar, Khadija A. Sumra, Zainab Samad, Gerald S. Bloomfield, Salim S. Virani, Simon Walker, Gerardo Z. Gomez, Ay (…)2026-07-14
📄 medicine

Integrated Telemedicine and Psychological Counseling for Mental Health Outcomes in HCC Patients: A Multi-center Cohort Study

在一项针对中国349例肝细胞癌患者的多中心回顾性队列研究中,适度参与一项基于微信的整合远程医疗与心理咨询项目,与12个月时抑郁、生活质量、痛苦程度及睡眠质量在统计学意义上的显著改善相关,尽管这些增益通常未达到既定的临床意义阈值,且观察性设计限制了因果推断。

Feng Jiang, Xiaoqin Liang, Shuang Jin, Yan Li, Tianhong Cai, Haijun Tang2026-07-14