📄 medicine

Diagnostic challenge and surgical decision making for a duodenal spindle cell tumor mimicking a gastrointestinal stromal tumor

本病例报告强调了在影像学表现与浅表活检结果不一致时,将罕见的非胃肠道间质瘤(non-GIST)型十二指肠梭形细胞肿瘤与胃肠道间质瘤进行鉴别诊断的难度,并最终表明在如此复杂的解剖场景下,手术策略应优先考虑局部可切除性,而非基于预设的术前诊断。

Jie Li, Guangyi Li2026-07-10
📄 medicine

Network Analysis of Teaching Self-Efficacy and Tacit Knowledge Sharing among Clinical Nursing Preceptors: A Multicenter Cross-Sectional Study

这项多中心横断面研究利用网络分析法,对中国1,221名临床护理带教教师在教学自我效能感与隐性知识共享之间的条目级关联进行了映射,识别出了诸如创造学习机会和经验外显化等关键中心节点与桥接节点,从而为有针对性的带教教师培训策略提供参考。

Jie Li, Zhining Liu, Chengwei Xu, Ming Jin, Zhiqiang Wang2026-07-10
📄 medicine

Pre-Operative Microbiome Signatures as Independent Predictors of Aggressive Prostate Cancer Phenotypes

这项前瞻性队列研究表明,术前微生物组特征,特别是粪肠球菌(*Enterococcus faecalis*)与肺炎克雷伯菌(*Klebsiella pneumoniae*)的共同定植,是侵袭性前列腺癌表型的独立预测因子,并且在超越前列腺特异性抗原(PSA)等传统临床指标方面显著提高了风险分层能力。

Pavlov Valentin Nikolaevich, Samuel Olalekan Akinyemi, VICTOR OLAMIPOSI OLAIYA, Urmantsev Marat Fayazovich, Tuguzbaeva G (…)2026-07-10
📄 medicine

The Mediating Role of Object Relations Quality and Defense Mechanisms in the relationship between ICD-11 Five-Factor Personality Traits and Current Suicidal Ideation in Major Depressive Disorder

这项针对386名重度抑郁障碍门诊患者的研究表明,虽然特定的ICD-11人格特质直接影响自杀意念,但客体关系质量和防御机制起到了显著的中介作用,凸显了在治疗干预中针对这些心理动力学结构进行干预的重要性。

Matin Khanpayeh, Kaveh Qaderi Bagajan, Soheib Amini, Kiyana Mardani, Bita zardar, Bakhtiar Piroozi2026-07-10
📄 medicine

Hemodynamic and ventilation/perfusion effects of continuous anterior chest compression in acute respiratory distress syndrome

在患有中重度ARDS的患者中,持续性前胸压缩可改善那些因过度扩张而导致平台压出现矛盾性下降的患者的右心室功能并降低后负荷,而在无反应者中则会通过增加分流来恶化通气/血流匹配。

Pascale Labedade, Samuel Tuffet, Paul Masi, Elsa Moncomble, Mohamed Boujelben, Anne-Fleur Haudebourg, François Bagate, A (…)2026-07-10
📄 medicine

Recurrent stroke following left atrial appendage closure in patients with ischemic stroke under oral anticoagulation: a systematic review and meta-analysis

这项针对 1,091 名既往在口服抗凝治疗下仍发生缺血性卒中高风险老年患者的系统评价和荟萃分析发现,左心耳封堵术与 3.1% 的残余年度缺血性卒中复发率相关,凸显了开展前瞻性试验以优化术后抗血栓策略的必要性。

Tommaso Bini, Marco Gamardella, Antanas Gasys, Roberto Galea, Laurent Roten, David Seiffge, Lorenz Räber, George CM Sion (…)2026-07-10
📄 medicine

Antibody-drug conjugates for advanced/recurrent high-grade endometrial cancer: potential targets, strategies and challenges

本综述通过总结抗体偶联药物(ADCs)目前的临床应用、临床前证据及早期临床试验结果,探讨了其作为晚期或复发性高级别子宫内膜癌治疗选择的新兴作用,同时也讨论了耐药机制以及克服这些挑战的未来课题。

Yusuke Matoba, Esther Rodman, Maryam Azimi Mohammadabadi, Sara Bouberhan, Oladapo Yeku, Bo Rueda2026-07-10