📄 medicine

Antibody-drug conjugates for advanced/recurrent high-grade endometrial cancer: potential targets, strategies and challenges

本综述通过总结抗体偶联药物(ADCs)目前的临床应用、临床前证据及早期临床试验结果,探讨了其作为晚期或复发性高级别子宫内膜癌治疗选择的新兴作用,同时也讨论了耐药机制以及克服这些挑战的未来课题。

Yusuke Matoba, Esther Rodman, Maryam Azimi Mohammadabadi, Sara Bouberhan, Oladapo Yeku, Bo Rueda2026-07-10
📄 medicine

Health in All Policies: The Impact of the Healthy City Pilot Policy on Cognitive Health and Cognitive Health Inequality Among Older Adults in China—Evidence from Difference-in-Differences and Double Machine Learning

本研究表明,中国的健康城市试点政策通过改善生活环境、健康行为、社会参与和数字包容性,显著提升了老年人的认知健康并降低了认知健康不平等,且其效果在不同的人口统计特征和地区群体中存在差异。

Jialin Xu, Longyi Huang, Qianwen Sun, Yang Luo, zixuan JiaoYang, Aijun Xu, Zhi Liu, Xuebin Qiao2026-07-10
📄 medicine

Selective versus complete caries removal in deep posterior lesions: a six-month prospective pilot

这项关于深部后牙病损中选择性去除与完全去除进行的为期六个月的前瞻性试点研究发现,尽管在双侧检验中差异未达到统计学显著性,但选择性去除显示出比完全去除在临床上具有相关性的、数值更高的成功率和牙髓敏感性,这凸显了开展更大规模、更长期试验的必要性。

Ana Iglesias Poveda2026-07-10
📄 medicine

Neuromuscular electrical stimulation versus combined aerobic and resistance exercise versus health literacy intervention for glycemic control in institutionalized older adults with type 2 diabetes: study protocol for a randomized controlled trial

本研究方案概述了一项三臂随机对照试验,旨在比较神经肌肉电刺激、监督下的有氧与抗阻联合运动以及健康素养教育在为期12周的时间内,对机构养老型2型糖尿病老年患者血糖控制及次要结局的影响。

Carlos Tavares, Rui Soles Gonçalves, Rocío Llamas-Ramos2026-07-10
📄 medicine

Tirzepatide Attenuates Diabetes-Associated Testicular Inflammation and Sperm DNA Fragmentation in Obese Diabetic Mice: Potential Pleiotropic Effects Beyond Glycemic Control

本研究表明,替泽帕肽通过睾丸巨噬细胞中的 GIPR 介导机制,改善了肥胖糖尿病小鼠的糖尿病诱导性睾丸炎症、氧化应激和精子 DNA 碎片化,从而展现出超越其血糖控制能力的保护作用。

Yusaku Mori, Naoya Osaka, Michishige Terasaki, Hironori Yashima, Tomomi Saito, Daiki Tokado, Madoka Ogino, Makoto Ohara (…)2026-07-10
📄 medicine

Physical Activity and Sedentary Behavior are Independently Associated with Combined Skeletal Muscle Index and Bone Mineral Density Status among Community-Dwelling Middle- Aged Women

这项针对199名40至64岁居住在社区的日本女性进行的横断面研究发现,较高的体力活动水平和较低的久坐时间与更佳的骨骼肌质量及骨矿物质密度综合状态独立相关。

Atsunori Itagaki, Issei Sugimoto, Ikue Kondo, Takumi Saito, Yugo Kimura, Sumika Ogawa, Koharu Takahashi, Aoba Kishi, Tom (…)2026-07-10
📄 medicine

Scoliosis in children and adolescents with NF1 and plexiform neurofibromas: a preliminary study of clinical phenotypes and eosinophil and basophil features

这项针对患有 1 型神经纤维瘤病(NF1)及丛状神经纤维瘤的儿童和青少年的初步研究表明,椎旁肿瘤浸润和外周嗜酸性粒细胞水平是与脊柱侧弯相关的独立因素,这表明将临床表型与特定的粒细胞特征相结合,可能有助于改善这一肌肉骨骼并发症的风险分层。

Zhixuan Fang, Qiaoyin Liu, Yifan Liu, Yanzhen Li, Nian Sun, Junlong Tan, Zhiyong Liu, Shengcai Wang2026-07-10
📄 medicine

The Efficacy and Safety of Radiofrequency Ablation for Trachea-Adjacent cT1N0M0 Papillary Thyroid Carcinoma: a five-year follow-up study

这项为期五年的随访研究表明,超声引导下的射频消融术是治疗邻近气管的 cT1N0M0 甲状腺乳头状癌的一种有效且安全的治疗选择,尽管与远处病灶相比,其与肿瘤背侧位置及气管接触相关的并发症风险略高,但其无病生存率和复发率相当。

Zimeng Lv, Jingchun Yang, Yifan Wang, Ying Chang, Xufen Yang, Xiaoxia Jia, Zhenpeng Leng2026-07-10