🧬 biology

Herpesviruses show consistency in their nuclear egress-associated induction of lamina-depleted areas (LDAs) as measured in an autofluorescent reporter cell model

本研究验证了一种自发荧光报告细胞模型,该模型能够量化多种疱疹病毒中普遍存在的层状缺失区(LDAs)诱导现象,并证明通过靶向病毒激酶介导的层蛋白 A/C 磷酸化或细胞异构酶活性,可以有效阻断这一关键的核输出步骤,并产生强大的抗病毒功效。

Kishore Dhotre, Lena Weghorn, Martin Schütz, Manfred Marschall2026-08-03
🧬 biology

Re-evaluating Percoll Density Gradient Centrifugation as a Bovine Sperm Sexing Method: DNA-Based Assessment and Field Fertility Outcomes in Holstein–Friesian Cattle in Lowland Indonesia

这项研究表明,在印度尼西亚荷斯坦-弗里生奶牛中,Percoll密度梯度离心法未能实现有意义的染色体富集或提高雌性犊牛产量,这已由基于DNA检测的极小X:Y偏移以及性别分离精液与非性别分离精液之间相当的田间受胎率结果所证实。

Habib Asshidiq Syah, Aulia Puspita Anugra Yekti, Nurul Isnaini, Putri Utami, Tri Eko Susilorini, Suyadi Suyadi, Mashudi (…)2026-08-03
🧬 biology

Computational study of phytocompounds derived from Glycine max as potential inhibitors of Estrogen Receptor alpha of breast cancer

这项计算研究通过全面的计算机虚拟筛选、分子对接和稳定性分析,确定了源自大豆(*Glycine max*)的两种植物化合物——齐墩果甾醇(Beta-Amyrin)和伪塔拉克萨甾醇(Pseudotaraxasterol),是乳腺癌中雌激素受体α(ERα)具有前景的潜在抑制剂。

Golam Gaus Mohiuddin, Mohammad Mahfuz Enam Elahi, Md. Jahed Rana, Md. Al Hafiz, Kaniz Fatema, Abir Hossain, Md. Shohel H (…)2026-08-03
🧬 biology

Differential Susceptibility of Salmonella enterica Serotypes to Antimicrobial Photodynamic Therapy: From Planktonic Eradication to Biofilm Recalcitrance

本研究表明,尽管光敏剂 C7 能有效清除浮游态沙门氏菌细胞并防止生物膜形成,但其对已形成的成熟生物膜的效力受到血清型特异性结构防御(尤其是具有强健宏观菌落结构的菌株)的显著限制。

Florencia Amancay Colocho, Juan Eduardo Silva, Francisca Ailín Rocca Plaza, Gabriela Isabel Favier, Carlos Rodolfo Pungi (…)2026-08-03
🧬 biology

High Trypanosome Infection Rate and Blood-Feeding Patterns of Tsetse Flies in South Ethiopia

一项在南埃塞俄比亚进行的研究显示,采采蝇的锥虫感染率高达17.1%,其中苍蝇种属 *Glossina pallidipes* 的流行率高于 *G. fuscipes fuscipes*,并确定了包括人类和狗在内的多种血食来源,这表明对牲畜和人类的寄生虫传播存在显著风险。

Tarekegn Desta, Kokeb Kore, Nigau Eligo, Girum Tamiru, Yilikal Tesfaye, Bernt Lindtjørn, Fekadu Massebo2026-08-03
🧬 biology

Does the invader win? Interspecific competition between the ambrosia beetles Xylosandrus germanus and Xyleborinus saxesenii

与入侵物种具有内在竞争优势的假设相反,本研究表明,本土象鼻小蠹 *Xyleborinus saxesenii* 及其共生真菌在直接相互作用中胜过了入侵物种 *Xylosandrus germanus*,这表明该入侵物种在欧洲的成功是由生态灵活性和重复引入驱动的,而非竞争优势。

Eleonora Cresta, Jon Andreja Nuotclà, Hannah Fiala, Stefano Speranza, Peter Biedermann2026-08-03
🧬 biology

A Minimal Two-State Allosteric Dimer Model for SARM1 Regulation and Paradoxical Activation by Orthosteric Inhibitors

本研究提出了一个极简的双状态 Monod-Wyman-Changeux 二聚体模型,旨在通过协同构象转变的框架,将生化动力学、结构数据和细胞实验统一起来,以解释代谢物对 SARM1 的调节作用以及低剂量下正构抑制剂引起的悖论性激活现象。

Soo Ro, Brett Babin, Jim Nonomiya, Jing Xue, Karla Manzanares, Maria Breboneria, Alexis Rohou, Matthew Johnson, Gladys B (…)2026-08-03
🧬 biology

Postbiotic Potential of Enterococcus faecium Cell-Free Supernatant: Dual Antimicrobial Efficacy Against Bacterial and Fungal Pathogens with GC-MS/LC-MS-Q-TOF Metabolite Characterization

本研究表明,通过对有机酸、脂肪酸以及经 GC-MS 和 LC-MS-Q-TOF 分析鉴定的生物活性肽等代谢物的协同作用,屎肠球菌(*Enterococcus faecium*)的无细胞上清液对细菌和真菌病原体展现出强大的双重抗菌功效,使其成为功能性食品和抗菌应用领域中极具前景的后生物制剂候选物。

Arati Chaudhary, Nidhi Prajapati, Anamika Pathak, Jinil Patel, Ashish Patel, Anil Patani, Dharmendrakumar Prajapati2026-08-03