360 papers
Biochemistry explores the intricate chemical processes that power life, bridging the gap between biology and chemistry to explain how molecules like proteins and DNA function within living cells. This field reveals the molecular machinery behind everything from metabolism to genetic inheritance, turning complex biological mysteries into understandable chemical interactions.
On Gist.Science, we bring you the freshest discoveries in this dynamic area directly from bioRxiv. Our team processes every new preprint uploaded to the server, transforming dense academic findings into both clear, plain-language overviews and detailed technical summaries. This dual approach ensures that whether you are a curious beginner or a seasoned researcher, you can grasp the significance of these breakthroughs immediately.
Below are the latest papers in biochemistry, complete with our curated summaries to help you navigate the cutting edge of molecular science.
This study establishes a rapid, scalable plate-clearing assay using *Vibrio natriegens* to screen for PET-hydrolyzing enzymes, successfully validating its utility by identifying a high-activity *Fusarium solani pisi* cutinase mutant and achieving a 25% hit rate in a library screen.
This paper presents two comprehensive quantitative proteomics datasets derived from mouse skin samples exposed to varying doses, dose rates, and time points of X-ray radiation, providing high-quality data to facilitate the discovery of biomarkers and the development of machine learning models for estimating radiation exposure.
This study systematically characterizes the yeast secretome under diverse proteosynthetic stress conditions, revealing distinct stress-specific secretion profiles and demonstrating that the intracellular chaperone BiP is secreted via unconventional pathways to function as an extracellular holdase that stabilizes misfolded client proteins under specific stress conditions like reductive stress.
This study demonstrates that inhibiting YAP/TAZ selectively suppresses the pro-fibrotic effects of TGF-β signaling in vocal fold fibroblasts while preserving protective feedback mechanisms, thereby offering a promising therapeutic strategy to prevent laryngeal fibrosis.
This study elucidates the full-length in-cell secondary structure of the breast cancer-associated lncRNA HOTAIR, revealing its multidomain architecture, context-specific structural features, and evolutionary conservation to provide a structural roadmap for understanding its role in gene regulation and metastasis.
This study demonstrates that catechinopyranocyanidins derived from adzuki beans exhibit potent antioxidant activity primarily driven by a hydrogen atom transfer mechanism and provide cytoprotective effects against mitochondrial dysfunction-induced cell death in human dermal fibroblasts.
This study employs APEX2-based dual proximity labeling coupled with data-independent acquisition mass spectrometry to comprehensively map the interactome of human TRMT1, revealing its association with RNA processing, tRNA biogenesis, and redox stress response pathways.
This study demonstrates that B3GNT7 is a critical regulator of colonic mucin O-glycosylation that maintains mucus integrity and protects against colitis and enteric infection.
This study elucidates how high enantioselectivity in borneol dehydrogenases evolved through a combination of a single active-site mutation (I111L) and peripheral mutations that modulate the hydrophobic pocket's solvent-accessible surface area, offering a blueprint for rational protein engineering.
This study reveals that the Rev1 scaffold protein exerts opposing regulatory control over DNA polymerase zeta by stimulating its activity on damaged DNA while inhibiting it on undamaged DNA through an evolutionary conserved N-terminal M1 motif, a mechanism that requires a stable Rev1-Pol zeta complex coordinated by PCNA and is critical for preventing complex mutations without altering overall spontaneous mutation rates.