13396 papers
A UK-wide survey of care home professionals reveals that significant delays in accessing controlled drugs for end-of-life care stem from fragmented pathways and staffing shortages, leading to a strong consensus that implementing on-site centralised stock—provided with robust governance and training—could substantially improve timely symptom management.
This study demonstrates that while alpinetin and losartan serve as effective prophylactic stabilizers against fructose-induced endothelial damage in HUVECs, cardamonin excels as a potent therapeutic agent for post-injury rescue, collectively highlighting the distinct cytoprotective potential of these phytochemicals.
This cross-sectional study of 380 unmarried Chinese women aged 16–30 reveals that both the frequency and perceived effectiveness of non-pharmacological self-care strategies significantly reduce severe menstrual symptoms, with frequency acting as a key mediator in this relationship.
This study demonstrates that electroacupuncture alleviates pain in rats with knee osteoarthritis by activating the PI3K/Akt/mTOR signaling pathway to suppress excessive autophagy in the brain, thereby reducing inflammation and structural joint damage.
This large multi-region cross-sectional study of nearly 10,000 Chinese families with children aged 0–3 reveals significant urban–rural disparities in home caregiving environments, particularly regarding higher screen exposure and fewer early learning resources in rural areas, while highlighting the predominant role of grandparents as primary caregivers across both groups.
This single-center retrospective study of 89 patients with traumatic cervical spinal cord injury identifies neuromuscular blocker use and high-level cervical injury (C1–C4) as independent risk factors for postoperative gastrointestinal dysfunction, revealing that while high-level injury confers a substantial baseline risk, neuromuscular blockers significantly increase the incidence of dysfunction in patients with lower-level injuries, suggesting that routine neuromuscular blocker use should be avoided.
This retrospective single-center study of Chinese children (2013–2023) reveals that while the Hib vaccine remains available but underutilized, allowing encapsulated *H. influenzae* to persist as a major cause of invasive disease, non-typeable *H. influenzae* (NTHi) has emerged as the predominant pathogen across all infection types with a significantly higher burden of antimicrobial resistance and distinct clonal characteristics.
This study utilizes GLASSO network analysis to reveal that Master of Nursing Specialist education quality in China is characterized by a multi-centred, flat network structure where supervisor support, research ability, and clinical practice ability serve as core hubs, while also demonstrating a synergistic interaction between management service and supervisor support.
This large-scale study of over 173,000 Chinese students identifies four distinct overall behavior patterns and reveals that profiles characterized by academic overload and excessive screen time are significantly associated with higher emotional and behavioral problems, while highlighting the moderating roles of gender, grade, and maternal education.
Although the phase II AMTEC trial evaluating olaparib plus durvalumab in non-BRCA-mutated metastatic triple-negative breast cancer failed to meet its primary endpoint, exploratory multi-omic analyses of on-treatment biopsies revealed that PARP inhibitor-induced adaptive changes in tumor and immune biology serve as robust predictors of response to the combination therapy.