📄 Category

medicine

7905 papers

📄 medicine

A Simplified Surgical Bypass for Complete Afferent Loop Obstruction After Pancreaticoduodenectomy Guided by Afferent Loop Length: A Case Report

This case report demonstrates that a simplified surgical bypass involving a direct side-to-side anastomosis between the proximal afferent loop and distal jejunum is a safe and effective treatment for complete recurrent afferent loop obstruction after pancreaticoduodenectomy in patients with a proximal loop length exceeding 50 cm and single-site obstruction, offering an alternative to permanent external drainage when endoscopic intervention fails.

Dongxue Geng, Dong Wei, Jingjing Tao2026-09-04
📄 medicine

Digital and Health Literacy Are Associated with Health-Related Quality of Life Across Cognitive Impairment Stages in Older Adults

This cross-sectional study of 303 older adults in South Korea reveals that digital and health literacy significantly predict health-related quality of life in those with normal or mildly impaired cognition, but this association diminishes as cognitive decline progresses to Alzheimer's disease.

Juhye Kim, Soyeong Lee, Jung-In Lim, Seonki Chung, Yeeun Byeon, Sewang Lee, Hayeon Song, Jun-Young Lee2026-09-04
📄 medicine

Axillary Single-Tube Drainage with Intracavitary Irrigation for Prepectoral Implant Infection: A Multicenter Experience

This multicenter study demonstrates that a standardized protocol of axillary single-tube drainage combined with intracavitary irrigation is an effective, simple, and reproducible method for salvaging infected prepectoral breast implants, achieving high success rates in both single-center and multicenter settings.

lianjie Niu, Qiang Zhang, Yan Li, Ulamu Yunus, Xianfu Sun2026-09-04
📄 medicine

Comparative Cavity Analysis and Druggability Assessment of Protein Structures 9iyx and 2c0k: Implications for Structure-Based Drug Design

This study compares the druggability of protein structures 9iyx and 2c0k using computational cavity analysis, revealing that 2c0k offers superior potential for diverse drug design due to its larger, high-scoring binding sites, while 9iyx presents opportunities for selective, high-affinity small molecule targeting despite its smaller cavities.

Bhat Sanjana, Rehman Meenal, Alam Sabrez2026-09-04
📄 medicine

Health needs of internally displaced persons from the Catatumbo region, Colombia: 2025

A 2025 cross-sectional study of 2,002 internally displaced persons in Cúcuta, Colombia, following renewed violence in the Catatumbo region, reveals that infectious diseases—particularly respiratory and gastrointestinal infections—constitute the primary health burden, with significant variations in condition prevalence based on age, gender, and nationality, underscoring the urgent need for a comprehensive emergency response that addresses both acute infections and chronic conditions.

Lianet Vazquez, Angela Restrepo, Lendy Rojas Bautista, Gustavo Rangel, Denisse Pareja Valarezo, Lindsey Martin, Zahra Sh (…)2026-09-04
📄 medicine

Appendix Tip Biopsy for Total Colonic Aganglionosis: Technical Aspects and Diagnostic Accuracy in a Prospective Cohort of 107 Pediatric Patients

This prospective study of 107 pediatric patients demonstrates that appendix tip biopsy is a highly accurate, reliable, and tissue-sparing diagnostic tool for total colonic aganglionosis, offering rapid results while preserving the proximal appendix for future reconstructive procedures.

Judith Lindert, Laura Stigler, Carla Sternke-Curvello, Andreas Erbersdobler, Stefanie Märzheuser2026-09-04
📄 medicine

“I wasn't interested in eating, so I wasn't”: A patient journey map of peri- operative nutrition concerns for cytoreductive surgery in ovarian cancer

This qualitative study of women undergoing cytoreductive surgery for ovarian cancer reveals that patients often feel overwhelmed and confused due to a lack of personalized nutrition guidance, conflicting information, and insufficient disease-specific resources, highlighting an urgent need for co-designed educational interventions.

Kathryn Cherry, Emma Quigley, Aisling Scully, Rhonda Farrell, Adrienne Young, Cherry Koh, Margaret Allman-Farinelli, Sha (…)2026-09-04
📄 medicine

Nonlinear associations of albumin and systemic immune-inflammation index with unfavourable in- hospital outcomes in ICU patients with severe tuberculosis: an explainable prediction modelling study

This study demonstrates that a compact panel of six admission variables, particularly highlighting the clinically significant nonlinear thresholds of albumin and systemic immune-inflammation index identified through explainable machine learning and spline analyses, enables effective early risk stratification for unfavorable outcomes in ICU patients with severe tuberculosis, with logistic regression offering a pragmatic and interpretable alternative to complex algorithms.

Xiayu Liu, Manjiao Fu, Jia Liu, Yao Tian, Jing Tan, Yinxia Dai, Chengli Bei2026-09-04
📄 medicine

A Cerebellar Radiomics Model Based on Automatic Segmentation and SHAP-Interpretable Machine Learning for Parkinson's Disease Discrimination

This study developed an interpretable machine learning model using automatic segmentation and radiomic features from cerebellar gray and white matter on 3DT1WI MRI scans to successfully distinguish Parkinson's disease patients from healthy controls, achieving an AUC of 0.714 in the testing set.

Yini Chen, Wengjie Wang, Andong Lin, Congcong Qi, Defa Yang, Li Ding, Linyou Wang2026-09-04
📄 medicine

Respiratory pathogen spectrum and coinfection patterns in acute respiratory infection patients during and post-COVID-19 pandemic from 2021 to 2025

This retrospective study of 9,674 hospitalized patients from 2021 to 2025 reveals that respiratory pathogen infections in China initially declined under strict non-pharmaceutical interventions but subsequently surged with policy relaxation, characterized by a predominance of *Mycoplasma pneumoniae* in lower respiratory tract infections and a high burden of multidrug-resistant bacterial co-infections in severe cases.

Ming-wen Zhao, Jie Yang, Yong-hui Li, Peng Qiu, Yu Zhang, Xiao-wen Zhang, Shan Gao, Jing Wang, Pei Zhao2026-09-04