📄 Category

medicine

3171 papers

📄 medicine

Interaction between acoustic intensity and focal depth in low-intensity focused ultrasound analgesia: A 2×2 factorial study in a rat model of inflammatory pain

This study demonstrates that in a rat model of inflammatory pain, shallow focal depth (3 mm) is the primary determinant of analgesic efficacy for low-intensity focused ultrasound acupuncture, significantly outperforming deeper stimulation and reversing pain-related protein upregulation without a significant interaction with acoustic intensity.

Fengjun Ni, Yong Yao, Xiaochen Weng, Huayuan Yang2026-07-23
📄 medicine

Determining the return on investment of a global adaptive platform trial for critically ill patients during COVID-19: A value of implementation analysis in low- and middle-income countries and globally

This study demonstrates that the REMAP-CAP adaptive platform trial provided a high return on investment globally and in low- and middle-income countries by significantly increasing corticosteroid use and reducing mortality among critically ill COVID-19 patients, resulting in net monetary savings even with substantial trial costs.

Lane Meredith, Abi Beane, Diptesh Aryal, Félix Camirand-Lemyre, Anais Charles-Nelson, Barbara Wanjiru Citarella, Fathima (…)2026-07-23
📄 medicine

Deep Learning-Enhanced EVA Test for Diagnostic Prediction of ADHD Among School- Aged Children

This study demonstrates that a deep learning-enhanced continuous performance test (EVA), utilizing an LSTM algorithm to analyze visual-auditory response data, achieves high diagnostic accuracy (AUC 0.990) for ADHD in school-aged children while reducing testing time and improving engagement compared to traditional methods.

Yuhan Deng, Yunfeng Fu, Wei Sun, Yang Li, Hongguang Zhang, Wei Deng, Chong You, Xiaohua Zhou2026-07-23
📄 medicine

Polypharmacologic Disruption of the Proliferative-to-Mesenchymal Fate Branch Point Reverses EndMT and Pulmonary Hypertension

The study identifies TK22, a polypharmacologic CDK5 inhibitor that simultaneously targets cell-cycle and mesenchymal kinase nodes, as a highly selective agent capable of erasing the pathological EndMT-competent endothelial state and reversing pulmonary hypertension without compromising normal endothelial function.

Ruslan Rafikov, Dinesh Bharti, Tetiana Kolodiazhna, Sedat Kacar, Mathews Varghese, Takanori Sano, Sruthi Radhakrishnan (…)2026-07-23
📄 medicine

Odor Identification and Descriptor-Specific Hedonic Olfactory Change After Roux-en-Y Gastric Bypass: A Prospective Controlled Cohort Study

This prospective controlled cohort study demonstrates that Roux-en-Y gastric bypass induces specific, descriptor-dependent changes in olfactory hedonic perception—particularly increased irritability and altered edibility ratings—over six months without affecting odor identification abilities.

Sergio Lincoln de Matos Arruda, Marcio Nakanishi, Luis Gustavo do Amaral Vinha, Pedro Renato Brandao, Rafael Oliveira Ga (…)2026-07-23
📄 medicine

Analysis of Delayed Medical Care Among Patients with Diabetic Retinopathy: Prevalence, Associated Factors, and Implications for Clinical Intervention

This cross-sectional study of 212 diabetic retinopathy patients in Shanghai reveals that delayed medical care affects over half of the cohort and is significantly driven by a combination of socioeconomic disadvantages, lack of health education, poor glycemic control, and lower psychobehavioral resilience, highlighting the need for targeted interventions to improve consultation timeliness.

Wenhui Dong, Zhongqing Xu2026-07-23
📄 medicine

Multi-Domain Machine Learning of VR-synchronised directional EEG phase connectivity reveals candidate Alzheimer's continuum biomarkers

By integrating immersive virtual reality with 64-channel EEG and phase transfer entropy analysis, this study demonstrates that directional brain connectivity patterns can accurately distinguish Alzheimer's disease, mild cognitive impairment, and normal cognition while identifying specific electrophysiological signatures as candidate biomarkers for the Alzheimer's continuum.

Eun Jung Park¹, Eun-Seong Kim, Do Hoon Kim, Nam Young Kim2026-07-23
📄 medicine

The correlation between risk perception and glycemic management decision-making behavior in pregnant women with gestational diabetes: a cross-sectional study

This cross-sectional study of 315 pregnant women with gestational diabetes reveals that risk perception, self-efficacy, and social support are significant positive predictors of glycemic management decision-making, whereas e-health literacy showed no significant direct or indirect impact.

Zining Wan, Yilin Huang, Huiying Ke, Yaping Xie, Ning Yang, Meijing Zhao, Huifen Zhao2026-07-23
📄 medicine

Internal jugular vein distensibility index versus changes in end-tidal CO2 to predict fluid responsiveness in mechanically ventilated patients with shock

This prospective diagnostic study of 80 mechanically ventilated shock patients demonstrates that the internal jugular vein distensibility index (IJVDi) and changes in end-tidal CO₂ (ΔETCO₂), particularly when used in combination, serve as reliable non-invasive predictors of fluid responsiveness with high diagnostic accuracy, offering a practical alternative to invasive monitoring.

Trirong Choosongdet, Nuntanuj Vutthikraivit, Preut Assawaworrarit, Monvasi Pachinburavan, Thitiwat Sriprasat2026-07-22