13396 papers
This study utilizes a unified systems model of 30 urban and peri-urban sites in Bangladesh to demonstrate that infectious disease emergence is driven by the synergistic interaction of rising temperatures, particulate pollution, and pathogen burden, with temperature and pollution significantly amplifying disease incidence in urban settings.
This two-center prospective exploratory study suggests that preanesthetic dynamic and positional carotid Doppler characteristics, particularly a waveform-derived dynamic index, may help identify maternal hemodynamic vulnerability to spinal anesthesia-induced hypotension during cesarean delivery, though these preliminary findings require validation in larger studies.
This single-institution retrospective analysis demonstrates that robot-assisted radical prostatectomy as part of multimodal therapy for NCCN very high-risk prostate cancer yields favorable perioperative safety and long-term survival outcomes, with a non-significant trend toward improved progression-free survival in patients receiving neoadjuvant therapy.
This study developed population-based statistical shape models to objectively quantify cranial morphology in sagittal craniosynostosis, demonstrating their utility in differentiating patient groups and evaluating the distinct postoperative outcomes of spring-assisted cranioplasty versus minimally invasive endoscopically assisted remodelling.
PKPy2 is a standalone Python framework that enables joint population pharmacokinetic and pharmacodynamic estimation, diagnostics, and uncertainty assessment by directly maximizing marginal likelihood, thereby improving parameter accuracy and convergence compared to its predecessor and demonstrating performance comparable to established tools like nlmixr2 and NONMEM.
This paper argues that effectively addressing rare diseases requires distinguishing between intrinsic scientific challenges that demand global collaboration and extrinsic health-system barriers that necessitate tailored national strategies, including comprehensive plans and layered registries that account for local realities and undiagnosed conditions.
This descriptive study of the Yagoua Health District in Cameroon reveals that while statistical significance was not reached, the 2024 floods caused substantial operational strain on health services, evidenced by sharp increases in hospitalizations, malnutrition, community births, and malaria cases alongside a decline in vaccinations.
This study developed and validated a nomogram model integrating contrast-enhanced CT histogram parameters (specifically corticomedullary phase skewness) with clinical features (monocyte count, NLR, and tumor size) to accurately predict preoperative Ki-67 expression status in patients with clear cell renal cell carcinoma.
Pre-clinical studies using cadaver arms and live pigs confirmed the feasibility of safely inserting a wirelessly enabled, levonorgestrel-releasing MEMS contraceptive into the upper arm, establishing specific anatomical guidelines and demonstrating normal healing without device migration over a 2-to-4-month period.
This study analyzes Israel's COVID-19 vaccine injury compensation claims from 2021 to 2026, revealing that approximately 22% of claims were approved based primarily on established causality criteria—such as temporal association and absence of prior comorbidities—rather than demographic or procedural factors.