📄 Category

medicine

13396 papers

📄 medicine

HFA-ICOS Risk Stratification for Trastuzumab-Related Cardiac Dysfunction in HER2- Positive Breast Cancer: A Cohort Study from Saudi Arabia

This retrospective cohort study of 369 Saudi Arabian patients demonstrates that the HFA-ICOS risk stratification tool effectively predicts trastuzumab-related cardiac dysfunction, with incidence rates rising sharply from 5.2% in low-risk to 58.3% in very high-risk patients, while also identifying diabetes and hypertension as significant comorbid risk factors.

Maryam Alqaseer¹, Sara Elfouad Mohamed Baker Elalfy, Mohammed Abdullatif Alabdullatif³, Ibtihal Abdulghani Alibrahim⁴, M (…)2026-10-23
📄 medicine

A Retrospective Analysis of Perinatal and Early Childhood Risk Factors in a Chinese Autism Spectrum Disorder Cohort

This retrospective study of a Chinese cohort identifies early childhood screen time and language developmental regression as significant risk factors for autism spectrum disorder diagnosis and severity, while noting that advanced paternal age is associated with milder symptoms.

Hui Wang, Hong-xia Zhao, Yu Du, Zheng-huan Mao, Wei-jun Chen, Li Ding, Ai-fen Zhao, Chuan-wen Wang, Chao-chun Zou, Hai F (…)2026-10-23
📄 medicine

Trajectories of Cardiopulmonary-Depressive Symptom Comorbidity Burden and Subsequent Activities of Daily Living Disability and Cognitive Function among Middle-Aged and Older Chinese Adults: A Nationally Representative Longitudinal Cohort Study

This nationally representative longitudinal study of Chinese adults identifies three distinct trajectories of cardiopulmonary-depressive comorbidity burden, revealing that both persistent high burden and rapidly increasing burden significantly predict future activities of daily living disability, while rapid accumulation specifically serves as a key risk factor for impaired memory function.

Fei Cao#, Yunhao Jiang#, Chen Chen2026-10-23
📄 medicine

Effects of Transcranial Direct Current Stimulation (tDCS) in Paracanoe Athletes: A Randomized Sham-Controlled Crossover Trial

This pilot randomized sham-controlled crossover trial found that a single session of anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex improved Stroop test accuracy and induced a shift toward sympathetic cardiac autonomic modulation in male para-canoe athletes, though these promising results require confirmation in larger samples.

Vinicius Munaro Vieira, Sol Levi Mendes Lima, Maria Eduarda Caldeira Souza Braz, Luciellen de Souza de Abreu, Karynne Ri (…)2026-10-23
📄 medicine

Associations of genetic predisposition to Alzheimer’s disease with blood-based biomarkers: a community-based study

This community-based study in rural China demonstrates that genetic predisposition to Alzheimer's disease, driven by APOE ε4 alleles and higher polygenic risk scores, is significantly associated with elevated plasma p-tau217, reduced Aβ42/Aβ40 ratios, and increased markers of neuroinflammation and systemic inflammation, particularly among older adults and females.

Tingting Hou, Qiuyu Wei, Lin Shi, Cuicui Liu, Min Zhu, Xunyao Tian, Heng Zhang, Na Tian, Keke Liu, Fernando Gonzalez-Ort (…)2026-10-23
📄 medicine

The True Accompaniers: An Exploration of CHWs' Navigation of Life and Death in the Burera District A Qualitative Study

This qualitative study reveals that Community Health Workers in Burera District, Rwanda, serve as essential, culturally grounded "true accompaniers" for terminally ill cancer patients by providing holistic, hope-centered care that transcends formal biomedical mandates, suggesting that future palliative programs should support and equip these workers rather than reorient them toward Western models of prognostic disclosure.

Celine Rukiidi, Alexandra Fehr, Amy Porter, Sarah Slater, Jason Beste, Sara Beste, Kevin Fuji, Florence Akiki, Grace Ili (…)2026-10-23
📄 medicine

Assessment of Anti-diabetic Potentials of Methanol Extract of Manihot dulcis Tuber in Aloxan- Induced Diabetic Wistar Rats

This study demonstrates that the methanol extract of *Manihot dulcis* tuber exhibits significant anti-diabetic potential in alloxan-induced diabetic Wistar rats by restoring body weight, increasing C-peptide levels, and reducing blood glucose, insulin resistance, and key digestive enzyme activities, though further comparative analysis with standard drugs like metformin is recommended.

Sonia Ufuoma VINCENT, Nduka Richard OSSAI, Santos Ehizokhale EHEBHA, Josiah Iju WILSON2026-10-23
📄 medicine

UCHL1 deubiquitinates and stabilizes SLC25A5 to drive pyrotinib resistance in HER2-positive breast cancer

This study identifies UCHL1 as a critical driver of pyrotinib resistance in HER2-positive breast cancer by deubiquitinating and stabilizing SLC25A5 to enhance autophagy and DNA damage repair, suggesting UCHL1 inhibition as a promising strategy to restore drug sensitivity.

Xinyuan Ding, Ying Zhu, Qian Liu, Juan Wu, Jianyu Xu, Zheng Wang, Renhong Huang, Minzhe Xu, Guangjuan Xu, YanXia Yu2026-10-23
📄 medicine

Normothermic Regional Perfusion in Pancreas and Islet Transplantation from Donation After Circulatory Death: A Systematic Review

This systematic review indicates that normothermic regional perfusion (NRP) for donation after circulatory death (DCD) pancreas and islet transplantation yields graft survival and utilization rates comparable to or better than super-rapid recovery DCD and donation after brain death, suggesting NRP should not be a barrier to transplanting these organs despite the very low certainty of the current evidence.

Malik Muhammad Makki, Samia Yunas2026-10-23
📄 medicine

Faecal microbiota transplantation in patients with irritable bowel syndrome modulates the gut microbiome but lacks clinical effects: results of a randomised, double-blind crossover clinical trial

In a randomized, double-blind, crossover clinical trial involving patients with irritable bowel syndrome, faecal microbiota transplantation successfully altered gut microbiome composition but failed to produce any significant clinical improvement in symptom severity.

Ondrej Cinek, Jiri Vejmelka, Jakub Hurych, Klara Hubackova, Iliya Dauda Kwoji, Matej Bezdicek, Karolina Litosova, Lucie (…)2026-10-23