3171 papers
This study demonstrates that while *Dracaena trifasciata* methanolic leaf extract is safe at low doses (≤250 mg/kg) in Wistar rats, prolonged administration of higher doses (500–1000 mg/kg) induces significant hepatotoxicity characterized by elevated liver enzymes and histopathological damage.
This paper describes a physician-led workflow using Google's AI co-scientist to rapidly generate and self-critique a set of testable, low-cost drug repurposing hypotheses for Alpha-Gal Syndrome, with metformin-guided oral immunotherapy emerging as the top candidate while emphasizing the necessity of independent validation.
This multi-source secondary analysis of Mexico's prison health system reveals significant gaps in chronic care access and treatment compared to national benchmarks, identifying higher occupancy and lower staffing as key drivers of unattended care and mortality while highlighting a correlation between supervisory deficiencies and reduced service provision.
This study utilizes a multi-diagnostic spatio-temporal Bayesian model to analyze malaria prevalence trends in Ghana from 2011 to 2025, revealing that while overall infection rates have declined significantly, the choice of diagnostic method (RDT vs. microscopy) leads to substantially different subnational risk classifications, highlighting the urgent need for standardized metrics to guide resource allocation in the era of dwindling funding.
This longitudinal case report proposes "Feeding Development" as a multidimensional framework for treating feeding selectivity in children with Autism Spectrum Disorder, demonstrating that prioritizing broader sensory, motor, behavioral, and family-based developmental changes leads to more comprehensive and sustainable improvements than focusing solely on food acceptance.
This systematic review of 18 experimental studies concludes that polyphenols derived from *Ficus* species, particularly flavonoids like quercetin and phenolic acids, show promising dual therapeutic potential for improving glycemic control and male fertility in Type 2 Diabetes Mellitus through antioxidant and enzyme-inhibiting mechanisms, though their translation to clinical practice awaits further human trials.
In a study of 726 young Asian adults, male sex, lower total body fat, reduced central adiposity, and lower perceived exertion were identified as the primary independent predictors of cardiorespiratory fitness, while systemic fat burden and central obesity exerted a stronger negative impact on aerobic capacity than regional subcutaneous fat distribution.
This study analyzing LASI Wave 1 data finds that broad migration categories in India fail to predict multidimensional health disadvantages in later adulthood, as adjusted differences between movers and non-movers are generally negligible and masked by the specific timing and reasons for migration, particularly for women moving before marriage.
This scoping review highlights how wearable technologies are transforming infectious disease management by enabling continuous, multi-sensor monitoring of vaccine and therapeutic responses throughout the intervention lifecycle, ultimately facilitating a shift from reactive care to personalized, data-driven, and potentially closed-loop therapeutic systems.
This retrospective cohort study of 621 male patients demonstrates that the combination of oral dutasteride 0.5 mg and oral minoxidil 2.5 mg is highly effective and well-tolerated for treating androgenetic alopecia, achieving significant hair improvement in over 60% of patients within six months, with notably better outcomes observed in those with more severe baseline disease.