📄 Category

medicine

7905 papers

📄 medicine

Effect of Low-Dose Nitroglycerin on Acute Respiratory Distress Syndrome in Elderly Patients after Major Surgery: A Randomized Controlled Trial

This randomized controlled trial demonstrates that intraoperative continuous infusion of low-dose nitroglycerin significantly reduces the incidence of postoperative acute respiratory distress syndrome (ARDS) in elderly patients undergoing major surgery, particularly benefiting those who are very elderly, high-risk, or undergoing major abdominal laparoscopic procedures.

Wenxia Lan, Yue Liu, Zheng Zhang, Xiang Li, Gangjian Luo2026-09-04
📄 medicine

Determinants of Clinical Research Engagement Among Healthcare Professionals in Private Hospitals in Somalia: A Cross-Sectional Study

This cross-sectional study of 384 healthcare professionals in private hospitals in Somalia's Benadir Region reveals that clinical research engagement is critically low (4.7%) and is significantly hindered by institutional barriers while being positively influenced by research knowledge, training, and financial support.

Faysal Abdullahi Salad, Abdullahi Mohamed Hamud, Yahye Abdulkadir Mohamed, Mahad Sadik Mukhtar2026-09-04
📄 medicine

Micturition-Triggered Bladder Paraganglioma Associated With Primary Aldosteronism: A Case Report

This case report describes a 60-year-old woman with a rare bladder paraganglioma causing micturition-triggered hypertension and coexisting primary aldosteronism, highlighting the diagnostic value of symptom-timed biochemical testing and the importance of continuing the workup for additional secondary causes even after identifying one.

Ying Zhao, Haoming You, Ranran Huang, Ning Zhang, Jiahui Zhao, Xiaoli Zhang, Jing Tian, Yunhong Wang2026-09-04
📄 medicine

Adapting brief behavioral therapy for insomnia for Team USA athletes: Development and pilot implementation of “REST USA”

This mixed-methods study developed and piloted "REST USA," an adapted Brief Behavioral Therapy for Insomnia for Team USA athletes, which demonstrated strong acceptability and preliminary efficacy in improving sleep symptoms and reducing anxiety, despite feasibility challenges related to assessment burden and device usability.

James D. Doorley, Ashley N. Triplett, Eric G. Post, Lauren Antonio, Emily Clark, Michael Clark, Heather K. Vincent, Jess (…)2026-09-04
📄 medicine

Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Nrf2 Levels in Cholangiocytes in Alcoholic Liver Disease

This study demonstrates that the downregulation of Type 3 inositol 1,4,5-trisphosphate receptor in cholangiocytes during alcohol-associated liver disease occurs independently of NF-κB, microRNA-506, and Nrf2 pathways, suggesting the involvement of alternative regulatory mechanisms.

Kemper Nunes Santos, Aline Rezende Ribeiro de Abreu, Guilherme Dantas Gomes, Antônio Carlos Melo Lima Filho, Paula Vieir (…)2026-09-04
📄 medicine

An RPA-CRISPR-Cas12a-Based Fluorescence and Lateral Flow Assay for the Detection of Ureaplasma urealyticum

This study presents a rapid, specific, and equipment-free dual-readout (fluorescence and lateral flow) diagnostic platform integrating RPA and CRISPR-Cas12a for the sensitive detection of *Ureaplasma urealyticum*, demonstrating high accuracy and suitability for point-of-care testing in resource-limited settings.

Feifei Zhang¹, Zhiping Zhang¹, Zhiqing Qi², Xiaomei Liu¹, Jing Wang¹, Xiaolu Chen¹, Yuexuan Wang¹, Rui Zhang¹, Mengying (…)2026-09-04
📄 medicine

Potassium Timing and Outcomes in Elective GI Tumor Surgery: A Propensity Score Analysis

In a propensity score analysis of 997 adults undergoing elective gastrointestinal tumor surgery, preoperative potassium optimization was found to significantly shorten anesthesia time but did not improve short-term recovery or morbidity outcomes compared to intraoperative supplementation, suggesting that delaying surgery solely for mild-to-moderate hypokalemia may be unnecessary.

Qunying Wang, Bangshu Zhao, Qian Wu, Fusen Huang, Qiuju Xiong, Dan Liu2026-09-04
📄 medicine

Ileal transcriptomic and mucosal microbiome features at resection are associated with postoperative recurrence in Crohn’s disease

This study demonstrates that subclinical inflammatory activation and specific mucosal microbial alterations in macroscopically normal ileal tissue at the time of surgery are associated with subsequent endoscopic recurrence in Crohn's disease patients, suggesting these molecular features could serve as early predictors of postoperative risk.

Moting Liu, Dianne Jansen, Tjasso Blokzijl, Zainab M.A. Al Radi, Froukje J. Hoogenboom, Johan F.M. Lange, Gerard Dijkstr (…)2026-09-04
📄 medicine

Molecular Heterogeneity and Organoid-Based Therapeutic Vulnerabilities of PIK3CA-Mutant Gastric Cancer

This study reveals that PIK3CA-mutant gastric cancers exhibit domain-specific molecular heterogeneity, where kinase-domain mutations are strongly associated with microsatellite instability and confer heightened sensitivity to PI3Kα inhibitor-based combination therapies, supporting the need for molecular stratification in precision treatment strategies.

Yao Fu, Shanshan Yang, Mengru Gao, Xiangshan Fan, Shouyu Wang2026-09-04
📄 medicine

Men’s knowledge of preconception care in Southern Ethiopia: magnitude and associated factors

A 2024 community-based study in Arba Minch, Southern Ethiopia, found that approximately 63% of married men possess knowledge of preconception care, a level significantly influenced by their wives' education, their own non-smoking status, adequate daily nutrition, and lower levels of loneliness.

Kassahun Fikadu, Ermias Worku, Seada Lemma, Haymanot Getnet, Hawlet Abdi, Kume Allo, Milton Kotelchuck2026-09-04