📄 medicine
UCHL1 deubiquitinates and stabilizes SLC25A5 to drive pyrotinib resistance in HER2-positive breast cancer
This study identifies UCHL1 as a critical driver of pyrotinib resistance in HER2-positive breast cancer by deubiquitinating and stabilizing SLC25A5 to enhance autophagy and DNA damage repair, suggesting UCHL1 inhibition as a promising strategy to restore drug sensitivity.
Original paper licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). This is an AI-generated explanation of the paper below. It is not written or endorsed by the authors. For technical accuracy, refer to the original paper. Read full disclaimer
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