3605 papers
This study demonstrates that a poloxamer-based intranasal clozapine sol-gel formulation achieves long-term antipsychotic effects in rats at just 4% of the oral therapeutic dose while potentially mitigating gut microbiome disruption associated with oral administration.
This prospective study conducted in a Nepalese tertiary care hospital demonstrates that serum Golgi Protein 73 (GP73) is a highly accurate noninvasive biomarker for distinguishing advanced chronic liver disease and severe fatty liver disease from early-stage fatty liver, outperforming conventional markers like FIB-4 and APRI.
This cross-sectional study analyzing three rounds of Liberia Demographic Health Survey data (2007–2019) reveals a concerning upward trend in unintended pregnancies among reproductive-age women, particularly adolescents, driven by factors such as unmet family planning needs, low modern contraceptive use, and specific demographic characteristics.
This descriptive cross-sectional study of 422 chronic kidney disease patients in Sri Lanka reveals that poor sleep quality and frequent distressing dreams, particularly nightmares, are prevalent and independently associated with higher levels of psychological distress, underscoring the need for routine screening of sleep and dream characteristics in nephrology care within low- and middle-income countries.
This study developed and validated a CatBoost-based machine learning model using nine clinical features to accurately predict preoperative anxiety in elderly hip fracture patients, with SHAP analysis identifying pain levels, age, and comorbidities as key risk factors.
This qualitative study utilizing the Social Ecological Model reveals that malaria persists in Cameroon due to a complex interplay of individual misconceptions, community-level socio-cultural and economic barriers, health system weaknesses, and policy implementation gaps, necessitating multi-sectoral and culturally sensitive interventions for effective control.
This retrospective study of 257 patients found that preoperative tamsulosin administration significantly reduces ureteroscopy failure rates, while flexible ureteroscopy is associated with a higher risk of failure compared to the semi-rigid approach.
This study clarifies that the endopelvic fascia is not an isolated membrane but a continuous connective tissue system linking the obturator fascia to the rectal wall and hiatal ligament, providing a crucial anatomical basis for defining surgical dissection planes in rectal cancer surgery.
This comparative neuropsychological study of Indian patients reveals that Progressive Supranuclear Palsy (PSP) exhibits significantly greater global and domain-specific cognitive impairment than Multiple System Atrophy (MSA), with PSP cognition closely linked to motor and mood severity while MSA cognition appears more driven by cognitive reserve.
This prospective study utilized microwave digestion and ICP-MS to analyze trace element and heavy metal profiles in gastrointestinal tumor versus healthy tissues, revealing significant associations between specific elemental alterations (particularly Cd, Pb, Fe, and Zn) and clinicopathological factors such as neoadjuvant therapy and lymphovascular invasion, thereby suggesting their potential as onco-biomarkers for personalized oncology.