3605 papers
This study demonstrates that moderate-to-late preterm birth independently increases the risk of severe lower respiratory tract infections across childhood and exhibits a significant synergistic interaction with respiratory syncytial virus (RSV) that amplifies disease severity, despite not altering susceptibility to pathogen acquisition.
This study demonstrates that inhaled pemetrexed-modified pulmonary surfactant nanoparticles loaded with paclitaxel (PEM-PSNP@PTX) effectively treat lung cancer by leveraging folate receptor-mediated dual targeting of tumor cells and macrophages to suppress tumor growth and reprogram the immunosuppressive microenvironment while minimizing systemic toxicity.
This study demonstrates that [68Ga]Ga-PentixaFor PET/CT frequently exhibits procedure-related uptake at surgical or interventional sites regardless of the time elapsed since the intervention or the anatomical location, highlighting a significant pitfall that correlates with [18F]FDG accumulation and may lead to false-positive interpretations.
This meta-research study demonstrates that systematic reviews of exercise interventions suffer from significant information loss compared to their source randomized controlled trials, primarily due to incomplete original reporting and further attrition during the synthesis process, particularly regarding equipment, adherence, provider characteristics, and tailoring methods.
This single-center quality improvement study demonstrates that a structured, physician-led educational intervention significantly enhances transition readiness, disease knowledge, self-management skills, and reproductive health awareness among adolescents with congenital heart disease.
This conceptual analysis argues that while existing biomedical appraisal tools effectively evaluate the technical soundness of study results, they fail to routinely verify whether the broader interpretations drawn from those results are actually supported by the specific comparisons the studies made, creating a critical gap between a result's validity and its application.
This study utilizing NHANES 2011–2018 data reveals that physically active US adults with prediabetes exhibit more diverse and strongly clustered cardiometabolic comorbidity patterns compared to their inactive counterparts, suggesting that physical activity fundamentally reshapes disease architecture rather than merely reducing prevalence.
This retrospective cohort study of 340 elderly hip fracture patients with perioperative atrial fibrillation reveals that the stress hyperglycemia ratio (SHR) exhibits a J-shaped nonlinear association with all-cause mortality and serves as an independent predictor that significantly enhances the prognostic accuracy of clinical models.
This case report details the complex clinical course and successful multidisciplinary management of a preterm infant with congenital cytomegalovirus infection who presented with severe neurological, hematological, hepatobiliary, cardiac, and ophthalmological complications, underscoring the critical importance of early diagnosis, coordinated specialist care, and long-term follow-up to optimize outcomes in this vulnerable population.
The paper introduces VIGIL, a validation-first research infrastructure that systematically extracts infectious disease intelligence from diverse open-source documents and continuously validates it against WHO reference data to quantify reporting biases and establish open-source signals as testable hypotheses rather than direct evidence.