📄 medicine

Long-term outcomes of fixed-duration venetoclax–rituximab in relapsed/refractory chronic lymphocytic leukemia: impact of prior BTK inhibitor exposure and measurable residual disease in a multicenter real-world study

In a multicenter real-world study of 90 relapsed/refractory CLL patients, fixed-duration venetoclax–rituximab demonstrated durable disease control with high response rates, although prior BTK inhibitor exposure, TP53 disruption, and the absence of undetectable measurable residual disease were identified as key factors associated with inferior progression-free survival.

Claudia Giordano, Giuliana Farina, Alberto Fresa, Mariano Lucignano, Fabio Trastulli, Barbara Pocali, Francesco Graziani (…)2026-10-18
📄 medicine

Impact of a Capillary Refill Time–Guided Personalised Hemodynamic Resuscitation Protocol in Septic Shock in Low- and Middle-Income Countries: A Post Hoc Analysis of the ANDROMEDA-SHOCK-2 Trial

A post hoc analysis of the ANDROMEDA-SHOCK-2 trial demonstrates that capillary refill time–guided personalized hemodynamic resuscitation yields consistent and significant benefits for patients with early septic shock in both low- and high-income countries, despite marked differences in baseline severity and resuscitation practices.

Alex Julián Forero-Delgadillo, Natalia Sanabria-Herrera, Valeria Aguirre Gutierrez, Juan Sebastián Hurtado, Daniel C. Te (…)2026-10-18
📄 medicine

Large Language Models in Hearing Care

This scoping review of 110 reports indicates that while large language models show promise for specific hearing care tasks, current evidence lacks proof of clinical benefit, prospective deployment, or robust privacy safeguards, highlighting an urgent need for future research focused on real-world impact, safety, and comparative effectiveness.

Shangqiguo Wang, Changgeng Mo, Jibin Wu, Alice K. Y. Siu, Fei Zhao, Jan-Willem A. Wasmann, De Wet Swanepoel, Vinaya Manc (…)2026-10-18
📄 medicine

Assessment of risk perception, knowledge, and trust in messages for COVID-19 control among most-at-risk communities in Uganda: A qualitative study

This qualitative study conducted in Uganda during August 2020 reveals that while most-at-risk communities possess high awareness of COVID-19 and trust Ministry of Health messages, adherence to preventive measures remains low due to varying risk perceptions, limited access to protective materials, and language barriers in communication.

Immaculate Nabukenya2026-10-18
📄 medicine

5-Aminolevulinic Acid-Guided Glioma Resection During Awake Craniotomy: Systematic Review of Functional Safety and Oncologic Benefit

This systematic review of 108 patients across 10 studies concludes that 5-aminolevulinic acid (5-ALA)-guided resection during awake craniotomy is a feasible and functionally safe technique that enhances tumor visualization and supports maximal safe resection in eloquent regions, particularly for high-grade gliomas, without increasing permanent neurological morbidity.

Mohammad Mofatteh2026-10-18
📄 medicine

The influence of music on technical skill in robotic surgery among general surgery residents: a simulation-based experimental study

This simulation-based study involving 32 general surgery residents found that listening to self-selected music did not significantly improve technical performance during early robotic surgery training, despite the protocol's feasibility and evidence of learning effects over time.

Guilherme Corvello Dias, Ramon Jorge Guiu, Pedro Henrique Alves Silva, Heitor Zancheta Andrade, Rodrigo Tavore Strasser (…)2026-10-18
📄 medicine

Comparison of parasitological, serological and molecular diagnostic methods for schistosomiasis japonica: insights into the detection of light infections

This study evaluated five diagnostic methods for *Schistosoma japonicum* in the Philippines, finding that while serological assays and molecular tests offer high sensitivity for detecting light infections, the Kato–Katz technique demonstrated the best overall discriminatory performance, highlighting that the optimal diagnostic tool depends on balancing accuracy with operational constraints like cost and field applicability.

Emmanuel John Tabilin, Yi Mu, Catherine A. Gordon, Mario A. Jiz, Eleonor Avenido-Cervantes, Marianette Inobaya, Yasuhito (…)2026-10-18
📄 medicine

Seroprevalence for Rift Valley Fever Virus and Associated Risk Factors in Cattle Slaughtered in Major Abattoirs of Federal Capital Territory, Abuja, Nigeria

This study reveals a low (1.1%) seroprevalence of Rift Valley Fever virus in cattle slaughtered in Abuja, Nigeria, while highlighting critical gaps in abattoir workers' knowledge and widespread risky practices that necessitate enhanced surveillance and targeted educational interventions to mitigate zoonotic transmission.

Jimada Bello Muhammed, Suleiman Salihu, Simon Ikechukwu Enem, Jonas Anayo Onah, Bolade thomas Adeyemo2026-10-18