5-Aminolevulinic Acid-Guided Glioma Resection During Awake Craniotomy: Systematic Review of Functional Safety and Oncologic Benefit
This systematic review of 108 patients across 10 studies concludes that 5-aminolevulinic acid (5-ALA)-guided resection during awake craniotomy is a feasible and functionally safe technique that enhances tumor visualization and supports maximal safe resection in eloquent regions, particularly for high-grade gliomas, without increasing permanent neurological morbidity.