3708 papers
This study demonstrates that the therapeutic efficacy of an HPV16 E6/E7 mRNA vaccine against tumors is significantly enhanced by incorporating a ubiquitin tag and a heterologous HSV-1 gD epitope to boost antigen presentation and T-cell help, with further improvements achieved through combination with immunomodulatory agents like entinostat or ADU-S100.
This study presents the first modern comprehensive characterization of the PELLAMAR sapropelic mud extract using FT-IR, Raman, TGA, and DSC techniques, confirming its high-quality mixed organic-mineral composition and validating its suitability for therapeutic and cosmeceutical applications.
This retrospective single-center study of 138 patients with traumatic cerebral venous sinus thrombosis (tCVST) reveals a 10.9% in-hospital mortality rate and suggests that while anticoagulation is associated with lower mortality in patients with less severe injuries, it does not significantly improve sinus recanalization rates, highlighting the need for further investigation into optimal management strategies given the condition's rarity and complex confounders.
A 2025 national multi-pathogen serosurvey in Niue utilized integrated serosurveillance to reveal low neglected tropical disease prevalence, high measles and rubella immunity, declining diphtheria and tetanus protection with age, and significant dengue and Cryptosporidium exposure, demonstrating the method's utility for guiding targeted public health strategies in Pacific Island settings.
This school-based cross-sectional study of nearly 9,500 Chinese adolescents reveals that scoliosis is significantly associated with female sex, higher grade levels, lower BMI, and specific sports behavior risks, while highlighting that higher levels of moderate-to-vigorous physical activity and lower sedentary time are protective factors.
This cross-sectional study of 1,108 Beijing schoolchildren reveals that social anxiety is indirectly associated with higher BMI and lower cardiorespiratory fitness through a serial mediation pathway involving reduced cognitive reappraisal and decreased sport engagement, rather than through direct links.
This quasi-experimental study found that after sixteen weeks, high-intensity static mat-based flexibility training significantly improved cervical rotation and hip extension range of motion in older adults and was superior to stick-assisted dynamic training for hip extension, while both methods led to reductions in certain shoulder and hip movements.
This study demonstrates that multimodal retinal imaging reveals a persistent microvascular phenotype characterized by reduced vessel density and increased tortuosity in patients with repaired aortic coarctation, which correlates with systemic hypertensive burden and may serve as a non-invasive biomarker for long-term cardiovascular risk.
This case report documents acute asymmetric mid-peripheral retinopathy and serous retinal detachment caused by low-dose intracameral cefuroxime in a vitrectomized eye with a compromised anterior-posterior barrier, highlighting the need for multimodal imaging to detect posterior segment toxicity when visual loss occurs with minimal anterior inflammation.
This cross-sectional study of 75 women with surgical menopause in Türkiye found that greater motivation for dementia-preventive lifestyle changes was significantly associated with a lower perceived dementia risk and a younger age at menopause, but not with dementia knowledge.