3708 papers
This case report demonstrates that a combination of immune checkpoint inhibitors and bevacizumab can achieve long-term disease control and a six-year overall survival in a patient with refractory clear cell renal cell carcinoma and brain metastasis who had previously failed multiple lines of tyrosine kinase inhibitor therapy.
This case report presents the first documented instance of congenital myotonic dystrophy type 1 associated with right hemidiaphragmatic eventration, utilizing serial diaphragmatic ultrasonography to characterize the unique structural atrophy and functional evolution of the diaphragm in an affected neonate.
This study of malaria trends in Kenya from 2008 to 2023 reveals a significant shift in the disease burden toward older age groups accompanied by a decline in parasite density, highlighting the urgent need to reassess age-targeted interventions to protect the population at highest risk.
The paper introduces **faers**, an open-source R/Bioconductor package that provides a standardized, high-fidelity framework for transforming raw FAERS data into analysis-ready formats through regulatory-compliant deduplication and automated terminology mapping, thereby enabling scalable, reproducible, and precise pharmacovigilance signal detection.
This quasi-experimental study involving 182 Hungarian high school students demonstrates that a 7-week school-based posture awareness intervention, featuring weekly training and daily reminders, significantly improved body awareness and back muscle endurance compared to a control group, though it did not affect abdominal muscle endurance.
This comparative qualitative study of public health nurses in Türkiye and Serbia reveals distinct approaches to colorectal cancer screening, with Turkish nurses demonstrating more comprehensive patient education and risk assessment practices while Serbian nurses highlight systemic barriers and educational gaps, underscoring the need for targeted training and policy support to improve early detection rates in both countries.
This 2024 U.S. study reveals that late maternal deaths (occurring 43–365 days postpartum) are predominantly driven by cardiovascular disease and behavioral causes with significant racial disparities, often occurring outside hospitals, and are heavily reliant on pregnancy checkbox classification, which suggests a need for extended postpartum care and vital record improvements.
This study demonstrates through prospective cohort and integrative genetic analyses that elevated serum gamma-glutamyl transferase (GGT) levels are significantly associated with an increased risk of frailty, mediated by metabolic, immune, and vascular pathways, suggesting GGT as a promising biomarker for identifying individuals at high risk.
This nationwide cohort study of Chinese middle-aged and older adults demonstrates that both higher cumulative exposure to and persistently high dynamic trajectories of the C-reactive protein-triglyceride-glucose index (CTI) are significantly associated with an increased risk of developing Cardiovascular-Kidney-Metabolic (CKM) syndrome stage 4.
A multicenter study of 1,005 Nigerian medical students reveals a high prevalence of psychological distress (81.3%) alongside critically low utilization of mental health services (9.3%), primarily driven by stigma and confidentiality concerns despite widespread willingness to seek help.