📄 medicine

Can Chest CT Differentiate Between Low-Risk and Higher Risk Congenital Lung Lesions in Infants?

This retrospective study demonstrates that chest CT can reliably differentiate low-risk congenital lung lesions (such as pulmonary sequestration and CPAM type 2) from higher-risk lesions (like CPAM type 1 and pleuropulmonary blastoma) in infants, thereby supporting the selection of candidates for conservative management.

Boaz Karmazyn, Sanjeev R Chilukuri, Matthew L Cooper, Irish A Starkey, Eric A Albright, Megan B Marine, Brandon P Brown (…)2026-10-18
📄 medicine

Comprehensive Prevention and Control Service Capacity for Hepatitis B in Medical and Health Institutions: A Cross-Sectional Survey in Jiangsu Province, China

A 2025 cross-sectional survey of 183 medical institutions in Jiangsu Province reveals that while HBV laboratory testing capacity is robust, particularly for HBsAg, comprehensive treatment and follow-up services remain heavily concentrated in tertiary hospitals, highlighting a critical need to strengthen primary-level participation and coordination across the prevention and control service chain.

Quan Kong, Lingen Shi, Jie Jiang, Xiaoyan Liu, Yuheng Chen, Dandan Yang2026-10-18
📄 medicine

Mortality trends and disparities in Clostridioides difficile infection with concurrent sepsis and acute kidney injury in the United States, 2000–2024

This study reveals that after a period of decline, U.S. mortality from *Clostridioides difficile* infection with concurrent sepsis and acute kidney injury significantly increased between 2019 and 2024, with the sharpest rises observed among adults aged 85 and older and across all racial and geographic groups.

Maxwell Trettin, Jaycee Thomas, John Rumbaugh2026-10-18
📄 medicine

Prevalence of eating disorders in Australian general from 2017 to 2022: a retrospective cohort

This retrospective cohort study of Australian general practice records from 2017 to 2022 reveals that the prevalence of eating disorders doubled over the period, with the most significant increases observed among younger women and those in wealthier areas, underscoring the urgent need for enhanced primary care support and targeted prevention strategies.

Carla De Oliveira Bernardo, Viviane De Menezes Caceres, David Gonzalez-Chica, Campbell Thompson, Amrit Kaur Sandhu, Rami (…)2026-10-18
📄 medicine

Driving pressure-guided positive end-expiratory pressure for the prevention of postoperative atelectasis in children: a prospective, randomised, controlled clinical trial

This prospective, randomized controlled trial demonstrates that individualizing positive end-expiratory pressure (PEEP) based on driving pressure significantly reduces the incidence of immediate postoperative atelectasis and improves lung ultrasound scores in children undergoing general anesthesia compared to fixed PEEP.

Qian Wang, Kuangyu Zhao, YanHong Li, Jiaqiang Zhang, Jun Zhou2026-10-18
📄 medicine

Mapping post-translational modifications across amyloid-β deposits in Alzheimer’s disease: A neuropathologic survey with in vitro functional analysis of nitration

This study reveals that post-translational modifications of amyloid-β exhibit distinct spatial signatures, with nitration specifically enriched in vascular deposits and shown to modulate aggregation kinetics and microglial activation, suggesting it as a potential biomarker for vascular pathology and a risk indicator for amyloid-related imaging abnormalities during immunotherapy.

Sarah Basile, Fleur Schipper, Stefania Zimbone, Sanne M.M. Vermorgen, Francesco Bellia, Cristina Parisi, Salvatore Sorti (…)2026-10-18
📄 medicine

A Four-Quadrant Phenotyping Model Based on Partitioned Exercise Pressure–Flow Slopes in Adolescent

This exploratory study introduces a four-quadrant phenotyping model based on partitioned exercise pressure–flow slopes to demonstrate that dissecting overall pulmonary vascular resistance into pre- and post-capillary components reveals dynamic post-capillary restriction as a frequent cause of reduced exercise capacity in adolescent Fontan patients, offering a refined approach for targeted therapeutic strategies.

Kouji Higashi, Tetsuko Ishii, Hiromichi Nakajima, Hiroyuki Aotsuka2026-10-18
📄 medicine

Deep learning integrated clinical-radiomics model for prognostic prediction in locally advanced cervical cancer through 18 F-FDG PET/CT and MRI combination

This study developed and validated a deep learning-integrated clinical-radiomics model (CRDLM) using combined 18F-FDG PET/CT and MRI data, which demonstrated superior prognostic prediction for disease progression in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy compared to conventional clinical factors and radiomics-only approaches.

Jinling Song, Kun Chen, Yuhuang Cai, Heqing Yi2026-10-18
📄 medicine

Homicidal intravenous elemental mercury toxicity presenting with widespread vascular embolization: a case report

This case report describes a rare instance of homicidal intravenous elemental mercury poisoning in a 48-year-old woman, which caused widespread vascular embolization and multi-organ toxicity that was successfully managed through early radiological identification and dimercaprol chelation therapy.

Jayashimman Vasanthraman, Upendra Baitha, Shikhar Gupta, Amandeep Singh, Rahul Krishnan, Bindu Prakash, Pankaj Jorwal, P (…)2026-10-18
📄 medicine

Clinical Outcomes of Rifaximin Combined with Probiotics in Patients with Functional Diarrhea A Prospective Cohort Study

This prospective cohort study suggests that combining rifaximin with probiotics may offer superior maintenance of improved stool consistency and reduced bowel frequency at one month compared to probiotics alone in adults with functional diarrhea, though these exploratory findings warrant confirmation through randomized controlled trials.

Jing Zhou, Guo-jian Yin, Yu-xin Liu, Feng-jie Ji2026-10-18